Detecting bleeding events using EHRs for prediction in Afib

使用 EHR 检测出血事件以预测心房颤动

• 批准号: 10159951
• 负责人: David D. McManus
• 金额: $ 79.66万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159951
• 关键词: Address; Adverse drug event; Affect; African American; Age; Aging; American; American Heart Association; Anticoagulant therapy; Anticoagulants; Atrial Fibrillation; Benefits and Risks; Cardiology; Caring; Characteristics; Clinical; Clinical Trials; Complex; Computer Models; Data; Decision Making; Detection; Diagnosis; Dose; Electronic Health Record; Emergency Situation; Event; Funding; Future; Healthcare Systems; Heart Atrium; Hemorrhage; Hospitals; Human; Individual; International Classification of Disease Codes; Knowledge; Leadership; Letters; Massachusetts; Medical; Minority; Minority Groups; Modeling; Myocardial Infarction; Natural Language Processing; Onset of illness; Oral; Outcome; Output; Patients; Performance; Pharmaceutical Preparations; Population; Primary Health Care; Provider; Records; Reference Standards; Research; Risk; Risk Factors; Scientist; Severities; Site; Stroke; Structure; Subgroup; System; Training; Trauma; Tsunami; United States National Institutes of Health; Universities; Visit; Vulnerable Populations; Woman; Work; base; clinically relevant; cohort; comorbidity; comparative effectiveness study; deep learning; falls; gastrointestinal; high risk; improved; innovation; instrument; neural network; novel; predictive modeling; risk prediction model; statistical learning; stroke risk; structured data; tool; trend; unstructured data

Abstract Atrial fibrillation (AF) affects millions of mostly older Americans. Atrial fibrillation contributes to stroke and weighing stroke risk against risk of bleeding from oral anticoagulants (AC) is central to AF management. AC decision-making has become more complex in recent years with the introduction of several target specific oral AC agents. It remains challenging to advise older AF patients about AC since they are frequently at high risk for stroke and complications from AC, particularly bleeding, and data are limited on real-world outcomes of AC among vulnerable populations. Our project, Detecting bleeding Events using Electronic records for Prediction in Atrial Fibrillation (DEEP AF), will leverage novel biomedical natural language processing (NLP) approaches to integrate bleeding-related information from both the structured and unstructured EHR records and statistical and deep learning approaches to predict risk of bleeding on AF patients on AC therapy. DEEP AF will address present knowledge gaps to accurately identify bleeding events from longitudinal electronic health records and to improve bleeding prediction accuracy and focus on modifiable, clinically relevant risk factors, thereby facilitating future large-scale comparative effectiveness studies evaluating AC agents, and helping clinicians develop better approaches to weighing AC risks and benefits.

抽象的 心房颤动（AF）影响数百万的大多数年长的美国人。心房颤动 导致中风和权衡中风风险，而口服流血风险 抗凝剂（AC）是AF管理的中心。交流决策已经成为 近年来，随着引入几个特定目标口服AC的更复杂 代理商。向老年AF患者提供有关AC的建议仍然具有挑战性 经常有中风和AC并发症的高风险，尤其是出血，以及 数据受到脆弱人群中AC的现实结果的限制。我们的 项目，使用电子记录检测出血事件以预测心房 纤颤（深AF）将利用新颖的生物医学自然语言处理 （NLP）从结构化和 非结构化的EHR记录以及统计和深度学习方法，以预测 对AF治疗的AF患者出血。深处AF将解决当前的知识差距 准确地确定纵向电子健康记录中的出血事件，并 提高出血预测准确性，并专注于可修改的临床相关风险 因素，从而促进未来的大规模比较效率研究 评估AC代理，并帮助临床医生开发更好的AC称重方法 风险和利益。

项目成果

Usability, Perceived Usefulness, and Shared Decision-Making Features of the AFib 2gether Mobile App: Protocol for a Single-Arm Intervention Study.

• DOI: 10.2196/21986
• 发表时间: 2021-02-24
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Kapoor A;Andrade A;Hayes A;Mazor K;Possidente C;Nolen K;Hegeman-Dingle R;McManus D
• 通讯作者: McManus D

Response by Hoque et al to Letter Regarding Article, "SUPPORT-AF II: Supporting Use of Anticoagulants Through Provider Profiling of Oral Anticoagulant Therapy for Atrial Fibrillation".

• DOI: 10.1161/circoutcomes.120.006671
• 发表时间: 2020-05
• 期刊: Circulation. Cardiovascular quality and outcomes
• 作者: Hoque L;McManus DD;Kapoor A
• 通讯作者: Kapoor A