Testing a culturally tailored behavioral intervention to reduce co-occurring substance use and HIV risk among stimulant-using Latinx Man who have sex with Man in South Florida.

项目摘要/摘要 职业目标。我的长期职业目标是：(1)获得并获得一份全职终身教职； (2)成为一名独立资助、社区参与的拉丁裔公共卫生科学家，以解决移民问题 拉丁裔人群的健康以及物质使用/艾滋病毒风险。这笔研究和培训助学金将为我提供 有机会加强我作为FIU博士后研究员的研究技能，成功地过渡到 预防干预科学家，解决使用兴奋剂的LMSM面临的突出健康不平等问题。 职业发展。这项K99/R00研究和培训计划将催化我获得先进的 必要的培训，以开发和测试文化知情的行为干预措施，解决 LMSM中兴奋剂的使用与HIV风险。在K99阶段，我的培训目标包括：(1)发展高级 设计基于文化的循证干预措施的能力；(2)在以下方面进行高级培训 随机对照试验方法，以检验其可行性、可接受性和初步疗效 文化知情的行为干预和(3)在应用SNA方法方面获得知识 评估文化知识行为干预对参与者社交网络构成的影响。 研究项目。拉美裔社区是美国增长最快的群体。24名LMSM(外国和美国出生) 不成比例地受到艾滋病毒和其他性传播疾病的影响。K99/R00提案将重点放在 在这些服务不足的使用兴奋剂的LMSM人群中，他们迫切需要文化知识 在PrEP时代减少共同使用兴奋剂和艾滋病毒风险的干预措施。发展一种行为 将文化因素和社会网络作为兴奋剂使用和艾滋病毒的关键决定因素的干预措施 LMSM的风险是一种可行的策略，可以减少兴奋剂的使用，减少无套肛门的参与度 性(CAS)，并支持在LMSM中摄取PrEP。明确的目标。(1)通过混合方式进行形成性研究 针对LMSM患者同时使用兴奋剂和HIV风险的文化知情干预方法 (2)进行试点随机对照试验，以测试其可行性、可接受性和 文化知情干预对优化PrEP摄取作为主要结果的初步疗效 60例使用LMSM兴奋剂。导师团队：我的努力将由一个成就卓著的跨学科团队来指导 导师团队致力于支持我向独立调查员的转变。

Project Summary/Abstract Career Goal. My long-term career goals are: (1) to obtain and secure a full-time tenure track appointment; and (2) to become an independently funded community-engaged Latinx public health scientist to address immigrant health as well as substance use/HIV risk in Latinx populations. This research and training grant will provide me with the opportunity to fortify my research skills as a postdoctoral fellow at FIU to successfully transition to a prevention intervention scientist that addresses prominent health inequalities faced by stimulant-using LMSM. Career Development. This K99/R00 research and training plan will catalyze my efforts to acquire the advanced training necessary to develop and test culturally informed behavioral interventions addressing the intersection of stimulant use and HIV risk in LMSM. During the K99 phase, my training goals consist of (1) developing advanced competencies in designing culturally informed evidence-based interventions;(2) pursuing advanced training in Randomize Control Trial methods necessary to examine the feasibility, acceptability, and preliminary efficacy of a culturally informed behavioral intervention and (3) acquire knowledge in the application of SNA methods to assess the effects of a culturally informed behavioral intervention on participant's social network composition. Research Project. Latinx communities are the fastest-growing group in the US.24 LMSM (foreign and US-born) are disproportionately affected by HIV and other sexually transmitted diseases. The K99/R00 proposal will focus on this underserved population of stimulant-using LMSM who are in desperate need of culturally informed interventions to mitigate co-occurring stimulant use and HIV risk in the era of PrEP. Developing a behavioral intervention that addresses cultural factors and social networks as key determinants of stimulant use and HIV risk in LMSM represents a viable strategy to reduce stimulant use, decrease engagement in condomless anal sex (CAS), and support PrEP uptake in LMSM. Specific Aims. (1) Conduct formative research through mixed methods to develop a culturally informed intervention targeting co-occurring stimulant use and HIV risk in LMSM who are not on PrEP and (2) Conduct a pilot Randomize Control Trial to test the feasibility, acceptability and preliminary efficacy of a culturally informed intervention for optimizing PrEP uptake as the primary outcome with 60 stimulant-using LMSM. Mentorship Team: My efforts will be guided by an accomplished, interdisciplinary team of mentors committed to support my transition to an independent investigator.