Testing a culturally tailored behavioral intervention to reduce co-occurring substance use and HIV risk among stimulant-using Latinx Man who have sex with Man in South Florida.

项目概要/摘要 职业目标。我的长期职业目标是：（1）获得并确保全职终身职位; (2)成为一个独立资助的社区参与拉丁公共卫生科学家，以解决移民 健康以及药物使用/艾滋病毒风险。这项研究和培训补助金将为我提供 有机会加强我的研究技能作为博士后研究员在金融情报，成功过渡到一个 预防干预科学家，解决使用兴奋剂的LMSM面临的突出的健康不平等。 职业发展。这个K99/R 00研究和培训计划将促进我的努力，以获得先进的 进行必要的培训，以制定和测试文化上知情的行为干预措施， LMSM中兴奋剂使用和HIV风险。在K99阶段，我的培训目标包括（1）开发高级 （2）在以下方面进行高级培训： 随机对照试验方法，用于检查药物的可行性、可接受性和初步疗效 一个文化知情的行为干预和（3）获得知识的SNA方法的应用， 评估文化上知情的行为干预对参与者的社会网络构成的影响。 研究项目。拉丁裔社区是美国增长最快的群体。24 LMSM（外国和美国出生） 受艾滋病毒和其他性传播疾病影响的妇女比例过高。K99/R 00提案将重点关注 对这些缺乏服务的使用兴奋剂的LMSM人群，他们迫切需要了解文化 干预措施，以减轻共同发生的兴奋剂使用和艾滋病毒的风险在时代的准备。 采取干预措施，将文化因素和社交网络作为兴奋剂使用和艾滋病毒的关键决定因素 LMSM的风险代表了一种可行的策略，以减少兴奋剂的使用，减少无避孕套肛门的参与， 性别（CAS），并支持LMSM中的PrEP摄取。具体目标。(1)通过混合的方式进行形成性研究 方法，以制定针对LMSM中同时发生的兴奋剂使用和艾滋病毒风险的文化知情干预措施 （2）进行一项试点随机对照试验，以测试可行性，可接受性和 一种文化上知情的干预措施对优化PrEP摄取作为主要结局的初步疗效， 60例使用兴奋剂的LMSM。导师团队：我的努力将由一个有成就的，跨学科的 一个导师团队致力于支持我向独立调查员的过渡。

Project Summary/Abstract Career Goal. My long-term career goals are: (1) to obtain and secure a full-time tenure track appointment; and (2) to become an independently funded community-engaged Latinx public health scientist to address immigrant health as well as substance use/HIV risk in Latinx populations. This research and training grant will provide me with the opportunity to fortify my research skills as a postdoctoral fellow at FIU to successfully transition to a prevention intervention scientist that addresses prominent health inequalities faced by stimulant-using LMSM. Career Development. This K99/R00 research and training plan will catalyze my efforts to acquire the advanced training necessary to develop and test culturally informed behavioral interventions addressing the intersection of stimulant use and HIV risk in LMSM. During the K99 phase, my training goals consist of (1) developing advanced competencies in designing culturally informed evidence-based interventions;(2) pursuing advanced training in Randomize Control Trial methods necessary to examine the feasibility, acceptability, and preliminary efficacy of a culturally informed behavioral intervention and (3) acquire knowledge in the application of SNA methods to assess the effects of a culturally informed behavioral intervention on participant's social network composition. Research Project. Latinx communities are the fastest-growing group in the US.24 LMSM (foreign and US-born) are disproportionately affected by HIV and other sexually transmitted diseases. The K99/R00 proposal will focus on this underserved population of stimulant-using LMSM who are in desperate need of culturally informed interventions to mitigate co-occurring stimulant use and HIV risk in the era of PrEP. Developing a behavioral intervention that addresses cultural factors and social networks as key determinants of stimulant use and HIV risk in LMSM represents a viable strategy to reduce stimulant use, decrease engagement in condomless anal sex (CAS), and support PrEP uptake in LMSM. Specific Aims. (1) Conduct formative research through mixed methods to develop a culturally informed intervention targeting co-occurring stimulant use and HIV risk in LMSM who are not on PrEP and (2) Conduct a pilot Randomize Control Trial to test the feasibility, acceptability and preliminary efficacy of a culturally informed intervention for optimizing PrEP uptake as the primary outcome with 60 stimulant-using LMSM. Mentorship Team: My efforts will be guided by an accomplished, interdisciplinary team of mentors committed to support my transition to an independent investigator.