Clear speech in ALS: Effects of feedback from a novel ASR practice paradigm and practice dosage

ALS 中的清晰言语：新型 ASR 练习范式和练习剂量的反馈效果

• 批准号: 10161598
• 负责人: Sarah Gutz
• 金额: $ 3.37万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10161598
• 关键词: Acoustics; Address; Adult; Affect; Amyotrophic Lateral Sclerosis; Articular Range of Motion; Caring; Communication impairment; Dysarthria; Etiology; Evidence based treatment; Face; Familiarity; Feedback; Flaccid Dysarthrias; Geography; Goals; Guidelines; Health Services Accessibility; Home; Impairment; Individual; Instruction; Judgment; Language; Lead; Learning; Life; Limb structure; Measures; Methods; Motor; Motor Neurons; Movement; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Noise; Outcome; Parkinson Disease; Participant; Patient Participation; Patients; Persons; Practice Guidelines; Quality of life; Research; Spastic Dysarthrias; Speech; Speech Disorders; Speech Intelligibility; Stroke; System; Time; Training; Treatment outcome; amyotrophic lateral sclerosis therapy; automated speech recognition; base; clear speech; dosage; evidence base; experience; improved; kinematics; learning outcome; motor learning; nervous system disorder; novel; spasticity

PROJECT SUMMARY Dysarthria is a motor speech impairment characterized by sensorimotor abnormalities that affect the movements required for speech, frequently resulting in reduced speech intelligibility and naturalness [1], [2]. Dysarthria often significantly impairs communication, in turn threatening a patient’s participation in daily life activities and quality of life [2]–[7]. However, relatively few treatments for dysarthria exist, and patient access to treatments is often limited by financial and geographic barriers [8]–[10]. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. Nearly all individuals with ALS will at some point experience speech impairment [11], [12], characterized by flaccid, spastic, or mixed flaccid- spastic dysarthria. Given the devastating loss of speech in ALS, there is a critical need for evidence-based treatments to help patients maintain their functional speech. Clear speech, which trains a mode of speech with deliberate enunciation, is a successful dysarthria treatment that globally affects the speech system and intelligibility. However, clear speech training uses subjective feedback from a partner, and its effects on intelligibility in ALS have been understudied. Additionally, although increased practice amount has been associated with positive motor learning outcomes in people with unimpaired motor function [13], [69], there is a dearth of research into the effects of single-session practice dosage on impaired limb [57] and motor speech function [10], [14]. This study investigates a novel method for providing feedback using noise-augmented automatic speech recognition to automatically and objectively facilitate clear speech treatment in healthy participants and participants with bulbar ALS. It also examines the effects of single-session practice dosage on learning a clear mode of speaking. Preliminary results support both nASR and increased practice dosage for facilitating clear speech.

项目摘要 构音障碍是一种运动性言语障碍，其特征是感觉运动异常， [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19构音障碍经常 严重损害沟通，进而威胁患者参与日常生活活动和质量 人生[2][7]然而，存在相对较少的用于构音障碍的治疗，并且患者获得治疗的途径通常是困难的。 受财政和地理障碍的限制[8]-[10]。肌萎缩侧索硬化症（ALS）是一种神经退行性疾病， 上、下运动神经元逐渐丧失的疾病。几乎所有ALS患者 [11][12][13][14][15][16][17][18][19 痉挛性构音障碍鉴于ALS患者严重的语言障碍，迫切需要循证医学。 帮助患者保持功能性语言。清晰的语言，它训练一种语言模式， 刻意发音，是一种成功的构音障碍治疗，全面影响语音系统， 可理解性然而，清晰的语音训练使用来自合作伙伴的主观反馈，其对 ALS中的可理解性已经被充分研究。此外，虽然增加了实践量， 与运动功能未受损的人的积极运动学习结果相关[13]，[69]， 缺乏关于单次练习剂量对受损肢体[57]和运动语言影响的研究 函数[10]，[14].本研究探讨了一种新的方法，提供反馈使用噪声增强 自动语音识别，以自动和客观地促进健康患者的清晰语音治疗， 参与者和延髓ALS参与者。它还研究了单次练习剂量对 学习清晰的说话方式。初步结果支持nASR和增加实践剂量， 便于清晰的语音。