Clear speech in ALS: Effects of feedback from a novel ASR practice paradigm and practice dosage

ALS 中的清晰言语：新型 ASR 练习范式和练习剂量的反馈效果

• 批准号: 10063254
• 负责人: Sarah Gutz
• 金额: $ 3.88万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10063254
• 关键词: Acoustics; Address; Adult; Affect; Amyotrophic Lateral Sclerosis; Articular Range of Motion; Caring; Communication impairment; Dysarthria; Etiology; Evidence based treatment; Face; Familiarity; Feedback; Flaccid Dysarthrias; Geography; Goals; Guidelines; Health Services Accessibility; Home environment; Impairment; Individual; Instruction; Judgment; Language; Lead; Learning; Life; Limb structure; Measures; Methods; Motor; Motor Neurons; Movement; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Noise; Outcome; Parkinson Disease; Participant; Patient Participation; Patients; Persons; Practice Guidelines; Quality of life; Research; Spastic Dysarthrias; Speech; Speech Disorders; Speech Intelligibility; Stroke; System; Time; Training; Treatment outcome; automated speech recognition; base; clear speech; dosage; evidence base; experience; improved; kinematics; learning outcome; motor learning; nervous system disorder; novel; spasticity

PROJECT SUMMARY Dysarthria is a motor speech impairment characterized by sensorimotor abnormalities that affect the movements required for speech, frequently resulting in reduced speech intelligibility and naturalness [1], [2]. Dysarthria often significantly impairs communication, in turn threatening a patient’s participation in daily life activities and quality of life [2]–[7]. However, relatively few treatments for dysarthria exist, and patient access to treatments is often limited by financial and geographic barriers [8]–[10]. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. Nearly all individuals with ALS will at some point experience speech impairment [11], [12], characterized by flaccid, spastic, or mixed flaccid- spastic dysarthria. Given the devastating loss of speech in ALS, there is a critical need for evidence-based treatments to help patients maintain their functional speech. Clear speech, which trains a mode of speech with deliberate enunciation, is a successful dysarthria treatment that globally affects the speech system and intelligibility. However, clear speech training uses subjective feedback from a partner, and its effects on intelligibility in ALS have been understudied. Additionally, although increased practice amount has been associated with positive motor learning outcomes in people with unimpaired motor function [13], [69], there is a dearth of research into the effects of single-session practice dosage on impaired limb [57] and motor speech function [10], [14]. This study investigates a novel method for providing feedback using noise-augmented automatic speech recognition to automatically and objectively facilitate clear speech treatment in healthy participants and participants with bulbar ALS. It also examines the effects of single-session practice dosage on learning a clear mode of speaking. Preliminary results support both nASR and increased practice dosage for facilitating clear speech.

项目总结 构音障碍是一种运动性言语障碍，其特征是影响运动的感觉运动异常。 语音所需的，经常导致语音清晰度和自然度降低[1]、[2]。构音障碍经常 严重损害沟通，进而威胁患者参与日常生活活动和质量 生活[2]-[7]。然而，构音障碍的治疗方法相对较少，患者往往很难获得治疗。 受资金和地理障碍的限制[8]-[10]。肌萎缩侧索硬化症是一种神经退行性疾病 一种以上下运动神经元的进行性丧失为特征的疾病。几乎所有ALS患者 在某种程度上会经历言语障碍[11]，[12]，以松弛、痉挛或混合性松弛为特征- 痉挛性构音障碍。鉴于肌萎缩侧索硬化症患者严重丧失语言能力，迫切需要循证医学。 帮助患者保持功能性言语的治疗。清晰的语言，它用来训练一种说话方式 刻意发音是一种成功的构音障碍治疗方法，它在全球范围内影响语言系统和 可理解性。然而，清晰的语言训练使用来自伴侣的主观反馈，以及它对 肌萎缩侧索硬化症的可理解性研究还不够深入。此外，尽管增加了练习数量，但 与运动功能未受损的人的积极运动学习结果有关[13]，[69]，有一种 缺乏关于单次练习剂量对肢体受损和运动语言的影响的研究[57] 函数[10]、[14]。这项研究调查了一种利用噪声增强来提供反馈的新方法 自动语音识别，自动客观地为健康人提供清晰的语音治疗 参与者和患有延髓肌萎缩侧索硬化症的参与者。它还检查了单次练习剂量对 学习一种清晰的说话方式。初步结果支持NASR和增加的实践剂量 促进清晰的演讲。