Biobehavioral basis of knee osteoarthritis pain

项目概要/摘要。 迫切需要发现和验证疼痛的强候选生物标志物和临床终点， 可用于促进从发现到II期临床的非阿片类疼痛治疗剂的开发 审判使用生物标志物组合的新兴研究提供了对未来大脑的个性化预测 和身体健康。我们自己的研究结果表明，行为慢性疼痛的特点是与 多种生物标志物，其中更大的疼痛负担与加速的有害生物学 流程.然而，迫切需要前瞻性研究来确定疼痛对异质性的影响。 这些生物过程在一个人阐明生物变化的基本模式， 一个生物行为的角度，这是需要预测未来的健康，并能够用于临床 干预措施的终点。拟议的研究将前瞻性地解决生物行为因素（即，认知， 影响膝关节疼痛和身体功能的体验和解释 在不同种族/民族群体中。我们将前瞻性地评估疼痛沿着多种生物标志物， 预测中年和老年非老年人认知、心理和身体功能进展的因素 西班牙裔黑人和非西班牙裔白人膝关节疼痛和控制超过四年的研究期间。强 来自佛罗里达大学的支持，我们的跨学科项目，使用一个全面的生物行为多， 方法的方法，我们将是第一个前瞻性地确定的轨迹和疼痛之间的相互作用， 生物学生物标志物和多个功能域的种族/种族群体在OA疼痛。发现将 有助于增加对疼痛及其生物行为基础的理解，并有可能减少 种族/民族群体差异，并改善疼痛相关的健康和功能结果。

Project Summary/Abstract. Discovery and validation of strong candidate biomarkers and clinical endpoints for pain is urgently needed that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials. Emerging research using a combination of biomarkers deliver individualized predictions about future brain and body health. Our own findings suggest that behavioral chronic pain characteristics are associated with multiple biological biomarkers where a greater pain burden is associated with accelerated detrimental biological processes. However, prospective research is urgently needed to determine pain’s impact on the heterogeneity of these biological processes within an individual to elucidate the underlying patterns of biological changes using a biobehavioral perspective which is needed for predicting future health and to be able to use as clinical endpoints for interventions. The proposed study will prospectively address biobehavioral factors (i.e., cognitive, psychological, social and cultural) affecting the experience and interpretation of knee pain and physical function across racial/ethnic groups over time. We will prospectively assess pain along with multiple biomarkers as predictors of cognitive, psychological and physical functional progression among middle-aged and older non- Hispanic Blacks and non-Hispanic Whites with knee pain and controls over a four-year study period. With strong support from the University of Florida, our interdisciplinary project, using a comprehensive biobehavioral multi- methods approach, we will be the first to prospectively determine the trajectory and interactions among pain, biological biomarkers and multiple domains of function within race/ethnic groups in OA pain. Findings will contribute towards increased understanding of pain and its biobehavioral basis, with the potential to reduce race/ethnic group disparities and improve pain-related health and functional outcomes.