Biobehavioral basis of knee OA
Biobehavioral basis of knee OA
批准号:
10290392
负责人:
Yenisel Cruz-Almeida
金额:
$37.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-05-15 至 2025-02-28
关键词:
Absence of pain sensationAddressAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAreaAwardBiological AgingBiological MarkersBrainBrain regionCognitiveDiagnosisElderlyEquilibriumEthnic groupGoalsHealthHumanIndividualKnee OsteoarthritisLiteratureMediatingMethodologyNeurobiologyNociceptionOutcomePainPain intensityPain managementParentsPathway interactionsPersonsPredispositionProcessRaceResearchRiskStimulusSystemTestingbiobehaviorchronic paincognitive functionconditioned pain modulationconditioningimprovedmultimodalityneuroimagingpain inhibitionpain processingpain reductionprospectiveracial and ethnicrecruitrelating to nervous systemresponsespinal reflextool
中文摘要
摘要所提出的研究表明与AD/ADRD的相关性
英文摘要
Abstract of the proposed research that shows the relevance to AD/ADRD
The susceptibility to pain depends on the balance of activity in ascending and descending pain
pathways. The descending pain control system modulates pain by inhibiting or facilitating nociceptive
processing. Well-established tools to study this system in humans are conditioned pain modulation
(CPM) paradigms in which pain intensity ratings of test stimuli are obtained in the presence and
absence of a concomitantly, remotely applied conditioning stimulus. More negative CPM responses (=
reduced pain intensity ratings under concurrent stimulation) are indicative of endogenous analgesia
(i.e., increased pain inhibition) and are mediated by spino-bulbo-spinal reflexes which are controlled by
higher cortical brain areas. Given that the same brain regions needed for descending pain modulation
are also negatively impacted in persons with Alzheimer's Disease (AD), aberrant descending pain
inhibition might contribute to altered pain processing in AD. To our knowledge no studies to date have
investigated descending pain inhibition in persons with AD nor its underlying mechanisms. The
proposed supplement will recruit 50 older adults diagnosed with mild AD with and without pain and
undergo experimental sessions of conditioned pain modulation, a cognitive function battery and multi-
modal neuroimaging consistent with the methodology used in the parent R01 award and compared with
individuals with knee osteoarthritis that are cognitively intact. The proposed research addresses a
significant gap in the literature and would be the first to evaluate the pain-related changes in the neural
substrates in older persons with and without AD in relation to pain. The identification of key top-down
modulatory brain networks impacted by pain and AD will increase our understanding of neurobiological
changes in pain processing that may put individuals at risk of developing AD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
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批准号:10671732
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项目类别:
-
资助金额:$20.2万
-
财政年份:2021
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
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批准号:10269273
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项目类别:
-
资助金额:$13.28万
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财政年份:2021
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负责人:Yenisel Cruz-Almeida
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依托单位:
Administrative Supplement for Training Activities to Enhance Wellness and Resiliency at UF
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批准号:10815124
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项目类别:
-
资助金额:$7.97万
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财政年份:2021
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负责人:Yenisel Cruz-Almeida
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依托单位:
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
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批准号:10454414
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项目类别:
-
资助金额:$13.37万
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财政年份:2021
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负责人:Yenisel Cruz-Almeida
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依托单位:
R01 Diversity Admin Supplement: Biobehavioral basis of knee osteoarthritis pain
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批准号:10302663
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项目类别:
-
资助金额:$8.66万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Biobehavioral basis of knee osteoarthritis pain
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批准号:10829700
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项目类别:
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资助金额:$16.46万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Biobehavioral basis of knee OA
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批准号:10540573
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项目类别:
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资助金额:$17.7万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Biobehavioral basis of knee osteoarthritis pain
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批准号:10353418
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项目类别:
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资助金额:$53.58万
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财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
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批准号:10161697
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项目类别:
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资助金额:$54.21万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
NOSI: Biobehavioral basis of knee osteoarthritis pain
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批准号:10331506
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项目类别:
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资助金额:$21.35万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Biobehavioral basis of knee osteoarthritis pain
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批准号:10558254
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项目类别:
-
资助金额:$8.66万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Biobehavioral basis of knee osteoarthritis pain
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批准号:10565913
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项目类别:
-
资助金额:$53.17万
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财政年份:2020
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负责人:Yenisel Cruz-Almeida
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依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
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批准号:10394186
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项目类别:
-
资助金额:$32.79万
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财政年份:2018
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负责人:Yenisel Cruz-Almeida
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依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
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批准号:9750588
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项目类别:
-
资助金额:$32.79万
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财政年份:2018
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负责人:Yenisel Cruz-Almeida
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依托单位:
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)
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批准号:10345884
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项目类别:
-
资助金额:$8.66万
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财政年份:2018
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负责人:Yenisel Cruz-Almeida
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依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
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批准号:10640497
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项目类别:
-
资助金额:$8.66万
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财政年份:2018
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负责人:Yenisel Cruz-Almeida
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依托单位:
Neuroimaging Age-Related Changes i Pain Modulation
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批准号:9269136
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项目类别:
-
资助金额:$11.87万
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财政年份:2015
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负责人:Yenisel Cruz-Almeida
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依托单位:
Pilot and Exploratory Studies Core
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批准号:10631879
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项目类别:
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资助金额:$16.92万
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财政年份:2007
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负责人:Yenisel Cruz-Almeida
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依托单位:
Pilot and Exploratory Studies Core
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批准号:10291466
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项目类别:
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资助金额:$18.57万
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财政年份:2007
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负责人:Yenisel Cruz-Almeida
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依托单位:
海外基金