Biobehavioral basis of knee OA
Biobehavioral basis of knee OA
批准号:
10290392
负责人:
Yenisel Cruz-Almeida
金额:
$37.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-05-15 至 2025-02-28
关键词:
Absence of pain sensationAddressAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAreaAwardBiological AgingBiological MarkersBrainBrain regionCognitiveDiagnosisElderlyEquilibriumEthnic groupGoalsHealthHumanIndividualKnee OsteoarthritisLiteratureMediatingMethodologyNeurobiologyNociceptionOutcomePainPain intensityPain managementParentsPathway interactionsPersonsPredispositionProcessRaceResearchRiskStimulusSystemTestingbiobehaviorchronic paincognitive functionconditioned pain modulationconditioningimprovedmultimodalityneuroimagingpain inhibitionpain processingpain reductionprospectiveracial and ethnicrecruitrelating to nervous systemresponsespinal reflextool
中文摘要
显示与AD/ADRD相关性的拟议研究摘要
对疼痛的敏感性取决于上升疼痛和下降疼痛的活动平衡
途径。下行疼痛控制系统通过抑制或促进伤害性感受来调节疼痛
处理.在人类中研究这一系统的成熟工具是条件性疼痛调制
(CPM)范例,其中测试刺激的疼痛强度等级是在存在和
没有伴随的、远程施加的条件刺激。更多的负面CPM响应(=
同时刺激下疼痛强度等级降低)指示内源性镇痛
(i.e.,增加的疼痛抑制),并由脊髓-延髓-脊髓反射介导,
高级大脑皮层区域。考虑到下行疼痛调制所需的大脑区域
也对阿尔茨海默病(AD)患者产生负面影响,
抑制可能有助于改变AD中的疼痛处理。据我们所知,迄今为止没有任何研究
研究了AD患者的下行疼痛抑制及其潜在机制。的
拟议的补充将招募50名被诊断患有轻度AD的老年人,
接受条件性疼痛调制的实验课程,认知功能电池和多-
模态神经成像与R 01研究中使用的方法一致,并与
患有膝关节骨关节炎但认知功能完好的个体。拟议的研究涉及一个
这是文献中的一个重大空白,将是第一个评估神经系统疼痛相关变化的人。
基质在老年人与非AD的疼痛。自顶向下的关键识别
受疼痛和AD影响的调节脑网络将增加我们对神经生物学的理解。
疼痛处理的变化可能会使个体处于发展AD的风险中。
英文摘要
Abstract of the proposed research that shows the relevance to AD/ADRD
The susceptibility to pain depends on the balance of activity in ascending and descending pain
pathways. The descending pain control system modulates pain by inhibiting or facilitating nociceptive
processing. Well-established tools to study this system in humans are conditioned pain modulation
(CPM) paradigms in which pain intensity ratings of test stimuli are obtained in the presence and
absence of a concomitantly, remotely applied conditioning stimulus. More negative CPM responses (=
reduced pain intensity ratings under concurrent stimulation) are indicative of endogenous analgesia
(i.e., increased pain inhibition) and are mediated by spino-bulbo-spinal reflexes which are controlled by
higher cortical brain areas. Given that the same brain regions needed for descending pain modulation
are also negatively impacted in persons with Alzheimer's Disease (AD), aberrant descending pain
inhibition might contribute to altered pain processing in AD. To our knowledge no studies to date have
investigated descending pain inhibition in persons with AD nor its underlying mechanisms. The
proposed supplement will recruit 50 older adults diagnosed with mild AD with and without pain and
undergo experimental sessions of conditioned pain modulation, a cognitive function battery and multi-
modal neuroimaging consistent with the methodology used in the parent R01 award and compared with
individuals with knee osteoarthritis that are cognitively intact. The proposed research addresses a
significant gap in the literature and would be the first to evaluate the pain-related changes in the neural
substrates in older persons with and without AD in relation to pain. The identification of key top-down
modulatory brain networks impacted by pain and AD will increase our understanding of neurobiological
changes in pain processing that may put individuals at risk of developing AD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
-
批准号:10671732
-
项目类别:
-
资助金额:$20.2万
-
财政年份:2021
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
-
批准号:10269273
-
项目类别:
-
资助金额:$13.28万
-
财政年份:2021
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Administrative Supplement for Training Activities to Enhance Wellness and Resiliency at UF
-
批准号:10815124
-
项目类别:
-
资助金额:$7.97万
-
财政年份:2021
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida
-
批准号:10454414
-
项目类别:
-
资助金额:$13.37万
-
财政年份:2021
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
R01 Diversity Admin Supplement: Biobehavioral basis of knee osteoarthritis pain
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批准号:10302663
-
项目类别:
-
资助金额:$8.66万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
-
批准号:10829700
-
项目类别:
-
资助金额:$16.46万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee OA
-
批准号:10540573
-
项目类别:
-
资助金额:$17.7万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
-
批准号:10353418
-
项目类别:
-
资助金额:$53.58万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
-
批准号:10161697
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项目类别:
-
资助金额:$54.21万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
NOSI: Biobehavioral basis of knee osteoarthritis pain
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批准号:10331506
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项目类别:
-
资助金额:$21.35万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
-
批准号:10558254
-
项目类别:
-
资助金额:$8.66万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Biobehavioral basis of knee osteoarthritis pain
-
批准号:10565913
-
项目类别:
-
资助金额:$53.17万
-
财政年份:2020
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
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批准号:10394186
-
项目类别:
-
资助金额:$32.79万
-
财政年份:2018
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
-
批准号:9750588
-
项目类别:
-
资助金额:$32.79万
-
财政年份:2018
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)
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批准号:10345884
-
项目类别:
-
资助金额:$8.66万
-
财政年份:2018
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Mechanisms of Oxytocins Analgesia in Older Adults
-
批准号:10640497
-
项目类别:
-
资助金额:$8.66万
-
财政年份:2018
-
负责人:Yenisel Cruz-Almeida
-
依托单位:
Neuroimaging Age-Related Changes i Pain Modulation
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批准号:9269136
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项目类别:
-
资助金额:$11.87万
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财政年份:2015
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负责人:Yenisel Cruz-Almeida
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依托单位:
Pilot and Exploratory Studies Core
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批准号:10631879
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项目类别:
-
资助金额:$16.92万
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财政年份:2007
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负责人:Yenisel Cruz-Almeida
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依托单位:
Pilot and Exploratory Studies Core
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批准号:10291466
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项目类别:
-
资助金额:$18.57万
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财政年份:2007
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负责人:Yenisel Cruz-Almeida
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依托单位:
海外基金