Basic Sciences Core

基础科学核心(核心C) 项目总结 利用DC CFAR伙伴机构的集体科学专业知识和资源，基本的 Science Core(BSC)将为艾滋病毒调查人员提供一系列高影响力的实验室服务和培训 在华盛顿特区。在NIH资助的资深科学家的领导下，以及华盛顿CFAR的一名干部- 支持核心服务提供商，BSC将提供基本的病毒学、免疫学、蛋白质组学、成像 以及包括单细胞分析在内的下一代测序服务，这些服务促进了对艾滋病毒的科学发现 研究。这些服务的目的是协助调查人员获得赠款申请的初步数据； 执行资助的研究方案；并促进与SWG以及临床和翻译的联系 调查人员。为实现具体目标1，中心将向CFAR调查员提供高影响力的实验室服务 它将被例行评估，并根据用户需求、科学进步 研究或开发新技术。对于具体目标2，核心将通过以下方式提供培训 个人层面的技术支持和更大规模的CFAR活动。这些服务包括实际操作的核心服务 实验室“开放参观”系列和一年一度的核心服务提供商研究日。核心领导层将 还与发展核心合作，为基础科学研究人员提供指导；鼓励 提交试点和过渡研究员奖和小额赠款；以及加强多学科 研究努力。最后，根据DC CFAR的总体任务，核心将侧重于 妇女和代表性不足的少数族裔调查人员帮助她们发展为独立的艾滋病毒实验室 科学家。

BASIC SCIENCES CORE (CORE C) PROJECT SUMMARY Leveraging the collective scientific expertise and resources across the DC CFAR partner institutions, the Basic Sciences Core (BSC) will provide an array of high impact laboratory services and training to HIV investigators in Washington, DC. Under the leadership of NIH-funded senior scientists and with a cadre of DC CFAR- supported Core service providers, the BSC will provide essential virology, immunology, proteomics, imaging and next-generation sequencing services including single cell analysis that foster scientific discovery in HIV research. These services are aimed at assisting investigators to acquire preliminary data for grant applications; conduct funded research protocols; and foster linkages with the SWGs and clinical and translational investigators. For Specific Aim 1, the Core will provide high impact laboratory services to CFAR investigators which will be evaluated routinely and updated or augmented based on user needs, advances in scientific research or the development of new technologies. For Specific Aim 2, the Core will provide training through individual-level technical support and larger CFAR-wide events. These include the hands-on Core service laboratory “open house” series and the annual Core Service Providers Research Day. The Core leadership will also collaborate with the Developmental Core to provide mentoring to basic science investigators; encourage submissions for pilot and transitioning investigator awards and microgrants; and strengthen multi-disciplinary research efforts. Lastly, consistent with the overall mission of the DC CFAR, the Core will focus on outreach to women and underrepresented minority investigators to assist their development as independent HIV laboratory scientists.