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Basic Sciences Core

基础科学核心

基本信息

批准号：
10640154
负责人：
SANJAY B. MAGGIRWAR
金额：
$ 25.2万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640154
关键词：
Acquired Immunodeficiency Syndrome Animal Model Antibodies Applications Grants Award Basic Science Binding Biological Assay Budgets Cells Clinical Investigator Collaborations Collection Computer software Confocal Microscopy Consult Consultations DNA sequencing Data Department chair Development District of Columbia Drug Modelings Drug Screening Education and Outreach Equipment Event Flow Cytometry Fostering Functional Imaging Funding Genomics HIV Image Image Analysis Immunologics Immunology Immunology procedure Individual Institution Interdisciplinary Study Investments Jordan Laboratories Laboratory Scientists Laboratory Technicians Leadership Maintenance Mass Spectrum Analysis Mentors Methods Microbiology Microscopy Mission Molecular Proteins Proteomics Protocols documentation Proxy RNA analysis Reagent Research Research Personnel Resources Scientist Senior Scientist Series Service provision Services Suggestion Surface Plasmon Resonance System Techniques Technology Tissues Training Training Programs Transmission Electron Microscopy Tropical Medicine Underrepresented Minority United States National Institutes of Health Universities Update Wages Washington Woman Work assay development cost image reconstruction in silico innovation instrument investigator training minority investigator molecular imaging new technology next generation sequencing novel outreach programs protein expression protein purification recruit research and development service providers single cell analysis single cell sequencing small molecule transcriptome sequencing translational scientist viral detection virology

项目摘要

BASIC SCIENCES CORE (CORE C) PROJECT SUMMARY Leveraging the collective scientific expertise and resources across the DC CFAR partner institutions, the Basic Sciences Core (BSC) will provide an array of high impact laboratory services and training to HIV investigators in Washington, DC. Under the leadership of NIH-funded senior scientists and with a cadre of DC CFAR- supported Core service providers, the BSC will provide essential virology, immunology, proteomics, imaging and next-generation sequencing services including single cell analysis that foster scientific discovery in HIV research. These services are aimed at assisting investigators to acquire preliminary data for grant applications; conduct funded research protocols; and foster linkages with the SWGs and clinical and translational investigators. For Specific Aim 1, the Core will provide high impact laboratory services to CFAR investigators which will be evaluated routinely and updated or augmented based on user needs, advances in scientific research or the development of new technologies. For Specific Aim 2, the Core will provide training through individual-level technical support and larger CFAR-wide events. These include the hands-on Core service laboratory “open house” series and the annual Core Service Providers Research Day. The Core leadership will also collaborate with the Developmental Core to provide mentoring to basic science investigators; encourage submissions for pilot and transitioning investigator awards and microgrants; and strengthen multi-disciplinary research efforts. Lastly, consistent with the overall mission of the DC CFAR, the Core will focus on outreach to women and underrepresented minority investigators to assist their development as independent HIV laboratory scientists.

基础科学核心（核心C）项目摘要利用DC CFAR伙伴机构的集体科学专业知识和资源，科学核心（BSC）将提供一系列高影响力的实验室服务和培训艾滋病毒调查人员在华盛顿在NIH资助的高级科学家的领导下，在DC CFAR的骨干下，支持的核心服务提供商，BSC将提供基本的病毒学，免疫学，蛋白质组学，成像以及下一代测序服务，包括促进艾滋病毒科学发现的单细胞分析 research.这些服务的目的是协助调查人员获得申请赠款的初步数据; 进行资助的研究方案;并促进与SWG和临床和翻译的联系 investigators.对于具体目标1，核心将为CFAR调查人员提供高影响力的实验室服务将根据用户需求、科学技术进步、研究或开发新技术。对于具体目标2，核心将通过以下方式提供培训：个人层面的技术支持和更大的CFAR范围内的活动。其中包括核心实践服务实验室“开放日”系列和年度核心服务提供商研究日。核心领导层将还与发展核心合作，为基础科学研究人员提供指导;鼓励提交试点和过渡期调查员奖励和小额赠款;加强多学科研究工作。最后，根据发展中国家CFAR的总体使命，核心小组将侧重于外联，妇女和代表性不足的少数民族调查人员，协助他们发展成为独立的艾滋病毒实验室科学家