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Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational Core

范德比尔特奥布莱恩肾脏中心 - 核心 D - 临床和转化核心

基本信息

批准号：
10163169
负责人：
TALAT Alp IKIZLER
金额：
$ 20.54万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10163169
关键词：
Acute Lung Injury Big Data Bioinformatics Biomedical Research Biometry Clinical Clinical Data Clinical Research Clinical Trials Closure by clamp Cohort Studies Collaborations Common Core Communities Coronary Artery Risk Development in Young Adults Study DNA Data Data Analyses Databases Diabetes Mellitus Diagnosis Digestive System Disorders Epidemiology Fostering Goals Grant Health Services Accessibility Human Image Informatics Infrastructure Institutes Interdisciplinary Study Investigation Investigational Drugs Jackson Heart Study Kidney Kidney Diseases Knowledge Link Macronutrients Nutrition Manuscripts Mission Molecular Biology Monitor National Institute of Diabetes and Digestive and Kidney Diseases Pilot Projects Population Predictive Analytics Procedures Process Prospective cohort Public Health Research Research Personnel Research Training Resource Sharing Resources Retrospective cohort Safety Sampling Services Specimen Strategic Planning Technical Expertise Therapeutic Tissues Translational Research Translations Veterans Writing base biobank biomarker validation clinical epidemiology computerized data processing data infrastructure data resource design diagnostic technologies energy balance experimental study health care delivery improved innovation insight member metabolic phenotype novel operation patient oriented research population based precision medicine research study sharing platform skills stable isotope

项目摘要

ABSTRACT The Clinical and Translational Core (Clinical Core) aims to facilitate patient-oriented research for investigators spanning from clinical translational research to population epidemiology. Resources and expertise will be pooled under the common Clinical Core umbrella to provide a wide range of clinical translational research resources including, but not limited to access to biosamples, technical resources such as sample analysis and biostatistical support and clinical data while increasing the efficiency of operations through expert knowledge for the construction, implementation and interpretation of the studies. The primary advantages of the Clinical Core are that 1) it enhances the quality of the experiments by providing a priori step- wise design process; 2) it alleviates experimental constraints by providing access to a variety of clinical research resources; and 3) it includes an infrastructure for data and sample coordination and storage. The Clinical Core will accomplish these goals by establishing three Subcores: 1) Biorepository Subcore; 2) Human Metabolic Phenotyping Subcore and 3) Clinical Epidemiology and Biostatistics Subcore. The internal and external users will access these resources by: 1) direct requests for biosamples, including tissue; 2) request for clinical and research data from large cohort studies, including BioVU and Research Derivative; 3) requesting statistical support for design and interpretation of new, ongoing or completed studies; and 4) request for analytical resources. For implementation and administration, the Clinical Core proposes to channel all information and specimens into analytical, statistical, and bioinformatics services, thereby enhancing the utility of these resources. The Clinical Core will also assist investigators in the process of communicating research findings to stakeholders and members of target communities that are partners in the research process. In accomplishing the goals, the Clinical Core will take advantage of available institutional resources, such as the Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt Diabetes Research and Training Center (DRTC) and Digestive Disease Research Center (DDRC).

摘要