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Regulation of scar free wound healing in salamanders

蝾螈无疤痕伤口愈合的调节

基本信息

批准号：
10163059
负责人：
Karen Echeverri
金额：
$ 27.66万
依托单位：
MARINE BIOLOGICAL LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10163059
关键词：
3&apos Untranslated Regions Address Ambystoma Animals Antibodies Blast Injuries Burn injury Candidate Disease Gene Cell Differentiation process Cell Fate Control Cell Proliferation Cell division Cell physiology Cells Chronic Cicatrix Collagen Data Deposition Dermal Dermis Development Disease Embryonic Development Epidermis Exhibits Fibroblasts Financial Hardship Gene Expression Gene Expression Profiling Genes Genetic Genetic Diseases Genetic Skin Diseases Health Human Image Impairment In Vitro Infection Injury Knowledge Label Link Mammals Messenger RNA MicroRNAs Molecular Natural regeneration Pathway interactions Patients Play Population Predisposition Process Process Measure Production Public Health Quality of life Recovery of Function Regulation Regulatory Element Regulatory Pathway Research Role Salamander Seeds Signal Pathway Skin Skin graft Skin repair Structure Testing Tissues Translating Translations Vertebrates Work Wound models angiogenesis cell type epidermal stem cell experience experimental study gene conservation healing human model improved in vitro Model in vivo innovation insight keratinocyte loss of function migration mouse model nerve supply novel open wound psychological trauma public health relevance regenerative repaired response response to injury screening severe burns skin disorder skin regeneration skin wound stem cell proliferation stem cells three-dimensional modeling tool transcription factor transcriptome transcriptome sequencing transcriptomics wound healing

项目摘要

Project Summary Serious skin disorders count among the most devastating health conditions and most difficult treatment challenges. These arise both from genetic diseases and from injuries, such as the often-debilitating long-term suffering of the >500,000 serious burn victims who are hospitalized every year in the US alone. Today's top treatments, including major skin grafts, still struggle to overcome the key natural limitations of human skin's relatively basic repair processes. While these generally restore structural integrity, they often result in extensive scarring that not only causes disfigurement and accompanying psychological trauma, but also significant loss of functionality, including impaired sensitivity and increased susceptibility to infection. The development of more effective skin therapies now stands to benefit greatly from emerging new understanding of the remarkable healing abilities exhibited by naturally regenerative vertebrates. To this end, our longstanding work on the “axolotl” salamander, the champion among such species, is identifying critical molecules, regulatory pathways and cellular processes underlying scar-free regeneration. Here, we will these address central issues in skin regeneration using cutting edge screening and analysis tools in axolotl. The aim of the project is to: 1) define the exact role of Sall4 in the dermis and epidermis for promoting scar free skin regeneration. 2) harness skin cell transcriptome data to define and functionally elucidate the role of different skin cell populations in regulating scar free regeneration. 3) We will translate our findings of the role of SALL4 in regulating collagen in axolotls into an in vitro model of human skin regeneration and use this new knowledge to attempt to promote scar- free wounding healing in human cells. In summary, these experiments will reveal and characterize key differences between the axolotl's regenerative and the mammal's non-regenerative responses to injury, identifying molecules and pathways required for the former to assess their potential for enhancing the latter. The ultimate aim of these studies is thus to improve quality of life for people with chronic open wounds and dysfunctional scar tissue.

项目总结

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Editorial overview - Differentiation: the driver of development.

编辑概述 - 差异化：发展的驱动力。

DOI：
10.1016/j.ceb.2021.11.001
发表时间：
2021
期刊：
Current opinion in cell biology
影响因子：
7.5
作者：
Echeverri,Karen;Kyba,Michael
通讯作者：
Kyba,Michael

Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.

DOI：
10.1016/bs.ctdb.2020.11.009
发表时间：
2021
期刊：
Current topics in developmental biology
影响因子：
0
作者：
Arenas Gómez CM;Echeverri K
通讯作者：
Echeverri K

Comparison of Blastema Formation after Injury in Two Cephalopod Species.

DOI：
10.17912/micropub.biology.000946
发表时间：
2023
期刊：
microPublication biology
影响因子：
0
作者：
Chavez Ramirez, Carlos;Khoo, Miya;Lopez G, Marco;Ferguson, Sophie;Walker, Sarah;Echeverri, Karen
通讯作者：
Echeverri, Karen

Regeneration: From cells to tissues to organisms.

再生：从细胞到组织再到生物体。