Core C: Data Management & Statistical

核心C：数据管理

• 批准号: 10164696
• 负责人: CHENGJIE XIONG
• 金额: $ 27.56万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10164696
• 关键词: Alzheimer' s Disease; Collaborations; Consult; Consultations; Data; Data Analyses; Data Set; Databases; Informatics; Institutes; Lead; Methodology; Progress Reports; Quality Control; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Statistical Methods; Techniques; Time; Work; data management; data submission; database design; design; novel; statistics

Core C: Data Management and Statistics Project Summary The Data Management and Statistics Core (DMSC) provides data management support and statistical consultation to facilitate research and sharing of other Cores/Components and research projects utilizing resources of the ADRC, as well as both local and collaborative analyses between and among AD Centers and with NACC. We aim: (1) to manage the ADRC-wide database, from the design of forms (if necessary) to data entry, to database quality control (QC), and finally to the distribution of analysis data sets to investigators and for progress reporting, by interacting closely with all Cores/Components that generate data; (2) to work closely with the WU Institute of Informatics (I2) to make data collected by ADRC Cores available to all ADRC investigators through an interface between REDCap and SAS; (3) to collaborate with NACC to make smooth and timely data submissions (e.g., the Uniform Data Set); (4) to lead and consult on the statistical design and data analyses of all ADRC projects with respect to the application of appropriate statistical and methodological techniques, and to develop novel statistical methods tackling emerging analytic challenges from ADRC Cores; (5) to promote reproducible research in the ADRC from database integrity to analytic integrity; (6) to facilitate local analyses and collaborations between and among ADCs and with NACC.

核心 C：数据管理和统计项目摘要 数据管理和统计核心（DMSC）提供数据管理支持和统计 咨询以促进其他核心/组件和研究项目的研究和共享 ADRC 的资源，以及 AD 中心之间的本地分析和协作分析 与 NACC 一起。我们的目标： (1) 管理ADRC范围的数据库，从表格设计（如果需要）到数据录入，到数据库 质量控制 (QC)，最后将分析数据集分发给研究人员并取得进展 通过与生成数据的所有核心/组件密切交互来进行报告； (2) 与 WU 信息学研究所 (I2) 密切合作，提供 ADRC 核心收集的数据 通过 REDCap 和 SAS 之间的接口向所有 ADRC 调查员提供信息； (3) 与NACC合作，顺利、及时地提交数据（例如统一数据集）； （四）领导并咨询ADRC所有项目的统计设计和数据分析工作 应用适当的统计和方法技术，并开发新的统计方法 解决 ADRC 核心新出现的分析挑战的方法； (5) 促进 ADRC 从数据库完整性到分析完整性的可重复性研究； (6) 促进 ADC 之间以及与 NACC 之间的本地分析和合作。