CORE--Biostatistics

生物统计学核心（核心C）将桥接从DIAN数据库的过渡，数据库由 信息学核心（核心H）的纵向数据的分析内，之间，和之间的 各种数据域，后者是核心的主要责任。特别是 生物统计学核心将：（1）监督研究数据的统计质量控制， 适当地去识别和统计分析数据集的分布/分析;（2）领导统计 数据分析，并在所有核心和项目的报告准备中进行合作，并就 （3）制定和实施关于所有项目和适用适当的统计和方法技术的政策; 针对潜在标志物的纵向变化实施适当的统计模型，并使用这些模型 为了检验关于AD临床前变化和关于AD的时间差异的统计学假设， AD临床前变化的各种标志物，和（4）作为其他研究人员的咨询小组 有兴趣使用DIAN数据库进行额外的分析。生物统计学核心将实现这些目标 通过与国家信息和通信网络所有其他部门的广泛互动和合作，实现具体目标。

The Biostatistics Core (Core C) will bridge the transition from the DIAN database stored and managed by the Informatics Core (Core H) to the analyses of the longitudinal data within, between, and among the various data domains, the latter of which serves as the primary responsibility of the Core. Specifically the Biostatistics Core will: (1) oversee the statistical quality control of data for the study and produce appropriately de-identified and statistically analyzable datasets for distribution/analysis; (2) lead the statistical data analyses and collaborate in report preparation for all Cores and projects, and consult on the design of all projects and on the application of appropriate statistical and methodological techniques; (3) develop and implement appropriate statistical models for longitudinal changes in potential markers and use these models to test the statistical hypotheses about the preclinical changes of AD and about the temporal difference on preclinical changes of AD among various markers, and (4) serve as an advisory group for other researchers interested in using the DIAN database for additional analyses. The Biostatistics core will achieve these specific aims through extensive interactions and collaborations with all other components of DIAN.