Core C: Data Management & Statistical

核心C：数据管理和统计项目摘要 数据管理和统计核心（DMSC）提供数据管理支持和统计 协商，以促进研究和共享其他核心/组件和研究项目， ADRC的资源，以及AD中心之间的本地和协作分析， 关于NACC我们的目标是： (1)管理ADRC范围内的数据库，从表格设计（如有必要）到数据输入，再到数据库 质量控制（QC），最后是将分析数据集分发给研究人员和进度 通过与生成数据的所有核心/组件密切互动进行报告; (2)与WU信息学研究所（I2）密切合作，提供ADRC核心收集的数据 通过REDCap和SAS之间的接口向所有ADRC调查人员提供; (3)与NACC合作，顺利及时地提交数据（例如，统一数据集）; (4)领导和咨询所有ADRC项目的统计设计和数据分析， 应用适当的统计和方法技术，并开发新的统计方法， 解决ADRC核心中出现的分析挑战的方法; (5)促进ADRC从数据库完整性到分析完整性的可重复研究; (6)促进地方分析以及发展合作委员会之间和与全国咨询委员会的合作。

Core C: Data Management and Statistics Project Summary The Data Management and Statistics Core (DMSC) provides data management support and statistical consultation to facilitate research and sharing of other Cores/Components and research projects utilizing resources of the ADRC, as well as both local and collaborative analyses between and among AD Centers and with NACC. We aim: (1) to manage the ADRC-wide database, from the design of forms (if necessary) to data entry, to database quality control (QC), and finally to the distribution of analysis data sets to investigators and for progress reporting, by interacting closely with all Cores/Components that generate data; (2) to work closely with the WU Institute of Informatics (I2) to make data collected by ADRC Cores available to all ADRC investigators through an interface between REDCap and SAS; (3) to collaborate with NACC to make smooth and timely data submissions (e.g., the Uniform Data Set); (4) to lead and consult on the statistical design and data analyses of all ADRC projects with respect to the application of appropriate statistical and methodological techniques, and to develop novel statistical methods tackling emerging analytic challenges from ADRC Cores; (5) to promote reproducible research in the ADRC from database integrity to analytic integrity; (6) to facilitate local analyses and collaborations between and among ADCs and with NACC.