Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity

有强烈的初级研究人员的兴趣和高级研究人员在细胞运输生理学的专业知识， 马歇尔大学医学院（MUSOM）。西方国家无数的健康差距中， 弗吉尼亚州/中阿巴拉契亚（WV/CA）的根源在于广泛的肥胖，这是该地区的流行病。在 作为这些差异的中心，MUSOM有能力解决这一问题。因此，这一新的总体目标 卓越生物医学研究中心（COBRE）的应用是促进细胞运输生理学 下一代生物医学研究人员对肥胖相关疾病的研究， 在Musom中实现这一目标所需的基础设施。阿巴拉契亚细胞转运中心 肥胖相关疾病（雅阁）将作为这个COBRE的学术之家。它将利用 现有的资源，如WV IDEA生物医学研究卓越网络（WV-INBRE）， 核心设施和新的机构资源，以培训初级调查员。每个COBRE项目都是 假设驱动;每个解决一个新的细胞转运改变在不同的肥胖相关 条件，并且每个都利用最先进的实验方法的创新互补状态。一 全面和互动的指导计划，关注每个初级学生的个性化需求 调查员和优秀的高级调查员担任导师，即由评价驱动， 成为独立的科学家。新的实践指导和网络机会将 进一步加强对初级调查员的培训。为了维持这些培训机会，同时 解决最流行的疾病之一，肥胖症，这是西弗吉尼亚州/加利福尼亚州许多健康差距的核心， 在全国范围内，新的资源（空间，资金和教师职位）已承诺由雅阁 机构。反过来，雅阁，以加强机构细胞运输在肥胖相关疾病的生物医学 研究能力，将开发新的资源作为未来的核心（如生物统计学和研究设计， 指导和劳动力发展preCores），并提供试点资金。雅阁COBRE提案 是至关重要的WV/CA，因为它专注于一个非常重要和非常及时的研究问题。是 创新，因为它研究肥胖相关疾病的细胞转运异常，与其他任何疾病都不同。 眼镜蛇因此，这个COBRE的新项目可能会确定新的目标， 不仅在WV/CA中被建模为改善和/或预防肥胖相关疾病的新疗法， 全国各地

There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at Marshall University’s School of Medicine (MUSOM). Many of the innumerable health disparities of West Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At the epicenter of these disparities, MUSOM is well positioned to address this. Thus, the overall goal of this new Center for Biomedical Research Excellence (COBRE) application is to promote cellular transport physiology research in obesity related diseases by the next generation of biomedical investigators and to enhance the necessary infrastructure to accomplish this at the MUSOM. The Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) will serve as the academic home for this COBRE. It will leverage existing resources such as the WV IDeA Network of Biomedical Research Excellence (WV-INBRE), excellent core facilities, and new institutional resources to train the junior investigators. Every COBRE project is hypothesis-driven; with each addressing a novel cellular transport alteration in a distinct obesity related condition, and each utilizing innovative complementary state of the art experimental approaches. A comprehensive and interactive mentoring plan with attention to the individualized needs of each junior investigator, and outstanding senior investigators as mentors, that is evaluation driven will train the junior investigators to become independent scientists. Novel hands-on mentoring and networking opportunities will further enhance the training of junior investigators. In order to sustain these many training opportunities, while addressing one of the most prevalent diseases, obesity, at the heart of many health disparities in WV/CA and nationwide, new resources (space, funding and faculty positions) have been committed to ACCORD by the institution. In turn, ACCORD, to enhance institutional cellular transport in obesity related disorders biomedical research capacity, will develop new resources as future Cores (e.g. Biostatistics and Study Design and Mentoring and Workforce Development preCores) and provide pilot funding. This ACCORD COBRE proposal is critical for WV/CA, as it focuses on a highly significant and extremely timely research problem. It is innovative because it studies cellular transport abnormalities in obesity related diseases, unique from any other COBRE. Thus, the novel projects of this COBRE will likely identify novel targets that can potentially be modeled as new therapeutics to ameliorate and/or prevent obesity related disorders not only in WV/CA, but across the country.