Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity

对细胞运输生理学有浓厚的初级研究员兴趣和高级研究员专业知识，请访问 马歇尔大学医学院(MUSOM)。西方无数的健康差距中的许多 弗吉尼亚州/阿巴拉契亚中部(WV/CA)的根源是广泛存在的肥胖症，肥胖症在该地区很流行。在… 作为这些差距的震中，MUSOM处于很好的地位来解决这一问题。因此，这一新的总体目标 生物医学研究卓越中心(COBRE)的应用是促进细胞运输生理学 下一代生物医学研究人员对肥胖相关疾病的研究，并加强 在MUSOM实现这一目标所需的基础设施。阿巴拉契亚细胞运输中心 肥胖相关疾病(ACCORD)将作为这位科布雷的学术之家。它将利用 现有资源，如WV IDEA生物医学研究卓越网络(WV-INBRE)，卓越 培训初级调查员的核心设施和新的机构资源。每个Cobre项目都是 假说驱动；每个假说都解决了与肥胖相关的新的细胞运输变化 每一种都利用了创新的互补的最先进的实验方法。一个 全面、互动的辅导计划，关注每个青少年的个性化需求 调查员，和优秀的高级调查员作为导师，即评估驱动将培养初级 调查人员将成为独立的科学家。新的实践指导和网络机会将 进一步加强初级侦查员培训。为了维持这么多的培训机会， 解决最普遍的疾病之一--肥胖，肥胖是西弗吉尼亚州和加利福尼亚州许多健康差距的核心 在全国范围内，新的资源(空间、资金和教员职位)已由ACCORD承诺 机构。反过来，ACCORD，以加强肥胖相关疾病的机构细胞运输生物医学 研究能力，将开发新的资源作为未来的核心(例如生物统计和研究设计和 指导和劳动力发展预核)，并提供试点资金。这一协议科布雷提议 对WV/CA来说至关重要，因为它集中在一个非常重要和非常及时的研究问题上。它是 创新是因为它研究了肥胖症相关疾病中的细胞运输异常，这一研究有别于其他任何疾病 科布雷。因此，科布雷的新项目可能会确定新的目标，这些目标可能 被建模为新的疗法，以改善和/或预防肥胖相关疾病，不仅在WV/CA，而且 在全国各地。

There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at Marshall University’s School of Medicine (MUSOM). Many of the innumerable health disparities of West Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At the epicenter of these disparities, MUSOM is well positioned to address this. Thus, the overall goal of this new Center for Biomedical Research Excellence (COBRE) application is to promote cellular transport physiology research in obesity related diseases by the next generation of biomedical investigators and to enhance the necessary infrastructure to accomplish this at the MUSOM. The Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) will serve as the academic home for this COBRE. It will leverage existing resources such as the WV IDeA Network of Biomedical Research Excellence (WV-INBRE), excellent core facilities, and new institutional resources to train the junior investigators. Every COBRE project is hypothesis-driven; with each addressing a novel cellular transport alteration in a distinct obesity related condition, and each utilizing innovative complementary state of the art experimental approaches. A comprehensive and interactive mentoring plan with attention to the individualized needs of each junior investigator, and outstanding senior investigators as mentors, that is evaluation driven will train the junior investigators to become independent scientists. Novel hands-on mentoring and networking opportunities will further enhance the training of junior investigators. In order to sustain these many training opportunities, while addressing one of the most prevalent diseases, obesity, at the heart of many health disparities in WV/CA and nationwide, new resources (space, funding and faculty positions) have been committed to ACCORD by the institution. In turn, ACCORD, to enhance institutional cellular transport in obesity related disorders biomedical research capacity, will develop new resources as future Cores (e.g. Biostatistics and Study Design and Mentoring and Workforce Development preCores) and provide pilot funding. This ACCORD COBRE proposal is critical for WV/CA, as it focuses on a highly significant and extremely timely research problem. It is innovative because it studies cellular transport abnormalities in obesity related diseases, unique from any other COBRE. Thus, the novel projects of this COBRE will likely identify novel targets that can potentially be modeled as new therapeutics to ameliorate and/or prevent obesity related disorders not only in WV/CA, but across the country.