Adipose derived secretome (ADS) uniquely regulates intestinal epithelial cell nutrient absorption during obesity

脂肪源性分泌组 (ADS) 独特地调节肥胖期间肠上皮细胞的营养吸收

• 批准号: 10165247
• 负责人: Soudamani Singh
• 金额: $ 17.63万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165247
• 关键词: Accountability; Address; Adipose tissue; Advisory Committees; Appalachian Region; Attention; Biomedical Research; Biometry; Budgets; Cellular Transport Alteration; Centers of Research Excellence; Clinical Sciences; Collaborations; Core Facility; Country; Development; Disease; Epidemic; Epithelial Cells; Evaluation; Faculty; Fostering; Funding; Funding Opportunities; Future; Future Generations; Genomics; Goals; Grant; Growth; Health; Heart; Home; Human Resources; Image; Individual; Infrastructure; Institution; Investments; Lead; Learning; Manuscripts; Mentors; Modeling; Molecular; Obesity; Obesity associated disease; Outcome; Phase; Physiology; Plant Roots; Policies; Positioning Attribute; Procedures; Program Evaluation; Publications; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Schools; Scientist; Time; Time Management; TimeLine; Training; Translating; Translational Research; United States; United States National Institutes of Health; Universities; West Virginia; Workforce Development; biomedical scientist; career development; career networking; cell growth regulation; graduate student; health care disparity; health disparity; innovation; interest; intestinal epithelium; medical schools; meetings; member; multidisciplinary; next generation; novel; novel therapeutics; nutrient absorption; obesity prevention; operation; student training; symposium; training opportunity; undergraduate student

There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at Marshall University’s School of Medicine (MUSOM). Many of the innumerable health disparities of West Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At the epicenter of these disparities, MUSOM is well positioned to address this. Thus, the overall goal of this new Center for Biomedical Research Excellence (COBRE) application is to promote cellular transport physiology research in obesity related diseases by the next generation of biomedical investigators and to enhance the necessary infrastructure to accomplish this at the MUSOM. The Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) will serve as the academic home for this COBRE. It will leverage existing resources such as the WV IDeA Network of Biomedical Research Excellence (WV-INBRE), excellent core facilities, and new institutional resources to train the junior investigators. Every COBRE project is hypothesis-driven; with each addressing a novel cellular transport alteration in a distinct obesity related condition, and each utilizing innovative complementary state of the art experimental approaches. A comprehensive and interactive mentoring plan with attention to the individualized needs of each junior investigator, and outstanding senior investigators as mentors, that is evaluation driven will train the junior investigators to become independent scientists. Novel hands-on mentoring and networking opportunities will further enhance the training of junior investigators. In order to sustain these many training opportunities, while addressing one of the most prevalent diseases, obesity, at the heart of many health disparities in WV/CA and nationwide, new resources (space, funding and faculty positions) have been committed to ACCORD by the institution. In turn, ACCORD, to enhance institutional cellular transport in obesity related disorders biomedical research capacity, will develop new resources as future Cores (e.g. Biostatistics and Study Design and Mentoring and Workforce Development preCores) and provide pilot funding. This ACCORD COBRE proposal is critical for WV/CA, as it focuses on a highly significant and extremely timely research problem. It is innovative because it studies cellular transport abnormalities in obesity related diseases, unique from any other COBRE. Thus, the novel projects of this COBRE will likely identify novel targets that can potentially be modeled as new therapeutics to ameliorate and/or prevent obesity related disorders not only in WV/CA, but across the country.

在细胞运输生理学方面有强烈的初级研究员兴趣和高级研究员专业知识 马歇尔大学医学院 (MUSOM)。西方无数的健康差异 弗吉尼亚州/阿巴拉契亚中部 (WV/CA) 的根源在于该地区普遍存在肥胖现象。在 作为这些差异的中心，MUSOM 完全有能力解决这一问题。因此，这个新的总体目标 卓越生物医学研究中心（COBRE）的应用是为了促进细胞运输生理学 下一代生物医学研究人员对肥胖相关疾病的研究，并加强 在 MUSOM 实现这一目标所需的基础设施。阿巴拉契亚蜂窝运输中心 肥胖相关疾病 (ACCORD) 将作为 COBRE 的学术中心。它将利用 现有资源，例如 WV IDeA 生物医学研究卓越网络 (WV-INBRE)、优秀 核心设施和新的机构资源来培训初级研究人员。每个 COBRE 项目都是 假设驱动；每一个都解决了与肥胖相关的独特的细胞运输改变 条件，并且每个都利用创新的互补的最先进的实验方法。一个 全面和互动的指导计划，关注每个青少年的个性化需求 研究者，以优秀的资深研究者为导师，即评价驱动，培养后辈 调查员成为独立科学家。新颖的实践指导和交流机会将 进一步加强初级调查人员的培训。为了维持这么多的培训机会，同时 解决最普遍的疾病之一——肥胖，它是西弗吉尼亚州/加利福尼亚州许多健康差距的核心问题 在全国范围内，新的资源（空间、资金和教员职位）已由 ACCORD 承诺 机构。反过来，ACCORD 可以增强肥胖相关疾病生物医学中的机构细胞运输 研究能力，将开发新资源作为未来的核心（例如生物统计学和研究设计和 指导和劳动力发展 preCores）并提供试点资金。此 ACCORD COBRE 提案 对于 WV/CA 至关重要，因为它专注于一个非常重要且极其及时的研究问题。这是 创新性在于它研究肥胖相关疾病中的细胞运输异常，这与任何其他疾病都是独一无二的 科布雷。因此，该 COBRE 的新项目可能会确定新的目标，这些目标可能会被 建模为新疗法，不仅可以改善和/或预防肥胖相关疾病，而且不仅适用于西弗吉尼亚州/加利福尼亚州，而且适用于 全国各地。