Pediatric Neurointensive Care and Resuscitation Research

神经危重病(NCC)是儿科危重病医学(PCCM)的最终前沿。最常见的 儿科重症监护病房(PICU)婴儿和儿童的死亡原因是神经系统 导致认知障碍和生活质量下降的神经性疾病的失败和流行 仍然高得令人无法接受。本T32研究性培训项目“儿科神经重症监护和 复苏研究“成立于2000年，代表着一项独特的国家计划。它培养医学博士、博士和 基础、翻译或临床研究的MD/博士，来自七个治疗婴儿和儿童的科室 他们需要从现场到急诊科、PICU和 康复和康复。我们的具体目标是指导临床医生，特别是儿童PCCM研究员 神经学、神经外科、PM&R、急诊医学、新生医学和放射学 博士后科学家，在研究培训中主要集中在两次侮辱，创伤性脑 受伤和心脏骤停。这两种疾病是发达国家儿童NCC的主要贡献者 世界。我们拥有萨法尔复苏研究中心独特而强大的资源和 匹兹堡大学医学中心匹兹堡大学医学院匹兹堡儿童医院 创建高度协作、多学科和多部门的研究文化 训练。我们的计划有一个精心策划的研究培训基础设施，并已进一步完善 包括三个焦点轨道(基础科学、翻译科学和临床科学)，每个都有共享和独特的 组件。它提供了来自24位国家认可的导师的尖端项目选择，并提供 有机会获得高级学位或参加有针对性的课程，以促进职业发展。在这 优秀的环境实习生努力实现五个目标1)以健全的原则为基础的教育 当代神经科学，2)他们成为学术临床医生--科学家或科学家，3)他们继续下去 为了获得独立的资金，4)他们最终成为该领域的领导者，以及5)他们完全 具备严格和道德研究并成功开发新的神经保护、复苏和 再生疗法，并改善所有儿童NCC的神经预后。学员将获得以下方面的支持 两三年。那些面向匹兹堡教师职位的人写K奖的申请。然而， 鉴于国家在儿科NCC研究方面对训练有素的研究人员的需求，我们的T32不仅仅是为了 造就本土人才。我们的学员不仅在匹兹堡发展成为独立资助的调查人员， 但已经成为该领域的全国领导者，独立资助其他中心的调查人员，现场PI NIH资助的试验，NCC项目的主任，以及晋升和/或捐赠的教师。我们的成功也是 由我们的九名初级教员“未来导师”重点介绍，他们由R21或K奖项资助，并担任 在我们领域的杰出成功典范，帮助指导我们的新学员。

Neurocritical care (NCC) is the final frontier in pediatric critical care medicine (PCCM). The most common cause of death in infants and children admitted to a pediatric intensive care unit (PICU) is neurological system failure and the prevalence of neuromorbidities causing cognitive impairment and reducing quality of life remains unacceptably high. This T32 research training program “Pediatric Neurointensive Care and Resuscitation Research,” established in 2000, represents a unique national program. It trains MDs, PhDs, and MD/PhDs in basic, translational, or clinical research, from seven departments that treat infants and children who require NCC across the continuum of care, from the field to the emergency department, the PICU, and to rehabilitation and recovery. Our Specific Aim is to mentor clinicians, specifically fellows in PCCM, Child Neurology, Neurosurgery, PM&R, Emergency Medicine, Newborn Medicine and Radiology along with postdoctoral PhD scientists, in research training focused predominantly around two insults, traumatic brain injury and cardiac arrest. Those two conditions are the leading contributors to pediatric NCC in the developed world. We feature the unique and formidable resources of the Safar Center for Resuscitation Research and the University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh in the University of Pittsburgh School of Medicine to create a highly collaborative, multi-disciplinary and multi-departmental culture for research training. Our program has a carefully orchestrated research training infrastructure that has been further refined to include three focus tracks (basic, translational, and clinical science), each with shared and unique components. It features a choice of cutting-edge projects from 24 nationally recognized mentors, and offers opportunities to obtain advanced degrees or take targeted courses to enhance career development. In this outstanding environment trainees work to attain five goals 1) an education grounded in the sound principles of contemporary neuroscience, 2) that they become academic clinician-scientists or scientists, 3) that they go on to obtain independent funding, 4) that they ultimately become leaders in the field, and 5) that they are fully equipped to rigorously and ethically study and successfully develop novel neuroprotective, resuscitative, and regenerative therapies, and improve neuro-outcomes across all of pediatric NCC. Trainees are supported for two or three years. Those targeted for faculty positions in Pittsburgh write K award applications. However, given the National need for trained investigators in pediatric NCC research, our T32 is not designed simply to create local talent. Our trainees have not only developed into independently funded investigators in Pittsburgh, but have become National leaders in the field, independently funded investigators at other centers, site PIs for NIH-funded trials, directors of NCC programs, and promoted and/or Endowed faculty. Our success is also highlighted by our nine junior faculty “Future Mentors,” who are funded by R21 or K awards and serve as outstanding exemplars of success in our field, to help guide our new trainees.