Mentoring in Translational Research to Prevent Disparities in Childhood Obesity and Cardiometabolic Disease

指导转化研究以防止儿童肥胖和心血管代谢疾病的差异

• 批准号: 10722684
• 负责人: Anisha Indravadan Patel
• 金额: $ 12.48万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-08 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10722684
• 关键词: Acculturation; Adoption; Affect; Age; Award; Biometry; Cardiometabolic Disease; Child; Child Care; Clinical; Clinical Investigator; Cluster randomized trial; Collaborations; Communities; Computer software; Cost Effectiveness Analysis; Data; Development; Dietary Assessment; Disease; Disparity; Dissemination and Implementation; Education; Effectiveness; Environment; Ethnic Origin; Faculty; Feedback; Fellowship; Fostering; Foundations; Funding; Future; Grant; Health; Health Policy; Health Services Research; Home; Income; Institution; Intake; Intervention; Leadership; Learning; Los Angeles; Low income; Maintenance; Manuscripts; Maternal and Child Health; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority Groups; National Heart, Lung, and Blood Institute; Nutrition Policy; Obesity; Overweight; Pediatrics; Policies; Policy Maker; Population; Prevention strategy; Public Health; Publishing; Race; Randomized, Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recording of previous events; Research; Research Institute; Research Personnel; Research Training; Residencies; Resources; Role; San Francisco; Schools; Science; Scientist; Statistical Data Interpretation; Students; Subgroup; Time; Training; Training Programs; Training and Infrastructure; Translating; Translational Research; Translations; Vision; Vocational Guidance; Water; Water consumption; Work; cardiometabolism; career; career development; children of color; clinical center; community engaged research; community setting; cost; dissemination science; drinking water; economic evaluation; elementary school; ethnic disparity; evidence base; experience; health organization; implementation intervention; implementation research; implementation science; implementation strategy; improved; innovation; medical schools; mid-career faculty; multidisciplinary; novel; obesity in children; obesity prevention; patient oriented research; pediatric department; pediatrician; peer coaching; population health; prevent; programs; racial disparity; sex; skills; socioeconomic disparity; sugar; sweetened beverage; therapy development; training opportunity; undergraduate student

PROJECT SUMMARY/ABSTRACT Dr. Anisha Patel is a midcareer pediatrician-researcher at Stanford applying for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR). Dr. Patel has excellent training in research (public health, health services research, community-engaged research, health policy). She has built an innovative research program that leverages community-academic-policy partnerships to prevent racial/ethnic and income-related disparities in obesity and cardiometabolic diseases funded by federal agencies, foundations, and institutional support. She also has an extensive history of mentoring in POR, with a particular emphasis on trainees underrepresented in health fields. As Associate Professor of Pediatrics at Stanford in many formal mentoring roles and as Director of Community-Engaged Research in Stanford’s Maternal and Child Health Research Institute, Dr. Patel is poised to mentor early and junior clinician-investigators in translational science. Dr. Patel is conducting numerous community-engaged studies to prevent racial/ethnic and socioeconomic disparities in childhood obesity that provide training opportunities for mentees. The first two aims of this application focus on two R01-funded cluster randomized-controlled trials (CRTs) examining the impact of drinking water promotion and access on children’s intake of water and sugar-sweetened beverages, and obesity in elementary schools (Water First, n=1249 students) and childcare centers (Healthy Drinks, Healthy Futures, n=420 children).This K24 award will leverage these two trials by applying the RE-AIM framework to examine the interventions’ reach, effectiveness, adoption, implementation, cost, and maintenance. The Specific Aims are to: 1) Estimate the short-term cost, population reach and effectiveness of Water First and Heathy Drinks, Healthy Futures interventions in increasing water intake, decreasing SSB intake, and preventing overweight, 2) Examine the impact of the interventions among different subgroups (by age, sex, racial/ethnic background, English proficiency and acculturation level), and 3) Describe how the impact of the interventions differ by fidelity to the intervention implementation strategies. These data will be used to translate evidence into practice and adapt the interventions for “real-world” settings. The research will also provide a platform for training experiences in conduct of CRTs, community-engaged research, dissemination and implementation science, intervention development, mixed methods, dietary assessment, and statistical analysis. The award will also allow Dr. Patel to expand her mentoring of early stage clinical investigators pursing translational POR and support her own career development in 1) gaining and applying mentorship and leadership skills, 2) building novel research with multi-disciplinary investigators, and 3) fostering new research expertise in dissemination and implementation research and economic evaluation at an opportune time in her career.

项目摘要/摘要 阿尼莎·帕特尔博士是斯坦福大学职业生涯中期的儿科医生兼研究员，申请的是K24职业中期调查员 以患者为中心的研究(POR)奖。Patel博士在研究(公共卫生、卫生)方面受过出色的培训 服务研究、社区参与研究、卫生政策)。她建立了一个创新的研究项目 它利用社区-学术-政策伙伴关系来防止种族/民族和与收入相关的差距 由联邦机构、基金会和机构支持资助的肥胖症和心脏代谢性疾病。 她还在POR有丰富的指导历史，特别强调对学员的指导 在卫生领域任职人数不足。在斯坦福大学担任儿科学副教授，多次接受正式指导 作为社区参与研究在斯坦福大学妇幼保健研究中的角色和主管 帕特尔博士将指导翻译科学领域的早期和初级临床医生和研究人员。帕特尔博士 正在进行许多社区参与的研究，以防止#年的种族/族裔和社会经济差距 为受训者提供培训机会的儿童肥胖症。这个应用程序的前两个目标集中在 两项由R01资助的群组随机对照试验(CRT)考察改善饮用水的影响 以及儿童对水和含糖饮料的摄入量，以及小学肥胖 (水第一，1249名学生)和托儿中心(健康饮料，健康未来，n=420名儿童)。 K24奖将利用这两个试验，应用RE-AIM框架来检查干预措施 覆盖范围、有效性、采用、实施、成本和维护。具体目标是：1)估算 水优先、健康饮料、健康未来的短期成本、人群覆盖范围和有效性 增加水摄入量、减少SSB摄入量和预防超重的干预措施，2)检查 干预措施对不同亚组的影响(按年龄、性别、种族/民族背景、英语 熟练程度和文化适应水平)，以及3)描述干预措施的影响如何通过对 干预实施策略。这些数据将被用来将证据转化为实践和适应 针对“真实世界”环境的干预。这项研究还将为培训经验提供一个平台 开展CRT、社区参与的研究、传播和实施科学、干预 发展、混合方法、饮食评估和统计分析。该奖项还将允许帕特尔博士 扩大她对寻求翻译POR的早期临床研究人员的指导，并支持她自己的 职业发展：1)获得并应用指导和领导技能；2)通过 多学科调查员；3)在传播和实施方面培养新的研究专门知识 在她职业生涯的适当时候进行研究和经济评估。