Mentoring in Translational Research to Prevent Disparities in Childhood Obesity and Cardiometabolic Disease

项目概要/摘要 Anisha Patel 博士是斯坦福大学的一名职业中期儿科医生兼研究员，正在申请 K24 职业中期研究员 以患者为导向的研究 (POR) 奖。帕特尔博士在研究方面接受过良好的培训（公共卫生、健康 服务研究、社区参与研究、卫生政策）。她建立了一个创新的研究计划 利用社区-学术-政策伙伴关系来防止种族/民族和收入相关的差异 由联邦机构、基金会和机构支持资助的肥胖和心脏代谢疾病领域。 她在 POR 方面也拥有丰富的指导经验，特别关注学员 在卫生领域代表性不足。作为斯坦福大学儿科副教授，接受过多次正式指导 担任斯坦福妇幼健康研究社区参与研究主任 研究所的帕特尔博士准备指导转化科学领域的早期和初级临床医生研究员。帕特尔博士 正在开展大量社区参与的研究，以防止种族/族裔和社会经济差异 儿童肥胖症，为学员提供培训机会。该应用程序的前两个目标集中于 两项由 R01 资助的整群随机对照试验 (CRT)，研究了饮用水推广的影响 儿童水和含糖饮料摄入量以及小学肥胖情况 （水第一，n = 1249 名学生）和托儿中心（健康饮料，健康未来，n = 420 名儿童）。 K24 奖将利用这两项试验，应用 RE-AIM 框架来检查干预措施的效果 范围、有效性、采用、实施、成本和维护。具体目标是： 1) 估计 Water First 和 Heath Drinks、Healthy Futures 的短期成本、人口覆盖范围和效果 增加水摄入量、减少 SSB 摄入量和预防超重的干预措施，2) 检查 干预措施对不同亚组的影响（按年龄、性别、种族/民族背景、英语 熟练程度和文化适应水平），以及 3）描述干预措施的影响如何因对目标的忠诚度而有所不同 干预实施策略。这些数据将用于将证据转化为实践并适应 对“现实世界”环境的干预。该研究还将提供一个培训经验的平台 开展 CRT、社区参与研究、传播和实施科学、干预 开发、混合方法、饮食评估和统计分析。该奖项还将让帕特尔博士 扩大她对追求转化 POR 的早期临床研究人员的指导，并支持她自己的 职业发展：1) 获得并应用指导和领导技能，2) 建立新颖的研究 多学科研究人员，3）在传播和实施方面培养新的研究专业知识 在她职业生涯的适当时机进行研究和经济评估。

PROJECT SUMMARY/ABSTRACT Dr. Anisha Patel is a midcareer pediatrician-researcher at Stanford applying for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR). Dr. Patel has excellent training in research (public health, health services research, community-engaged research, health policy). She has built an innovative research program that leverages community-academic-policy partnerships to prevent racial/ethnic and income-related disparities in obesity and cardiometabolic diseases funded by federal agencies, foundations, and institutional support. She also has an extensive history of mentoring in POR, with a particular emphasis on trainees underrepresented in health fields. As Associate Professor of Pediatrics at Stanford in many formal mentoring roles and as Director of Community-Engaged Research in Stanford’s Maternal and Child Health Research Institute, Dr. Patel is poised to mentor early and junior clinician-investigators in translational science. Dr. Patel is conducting numerous community-engaged studies to prevent racial/ethnic and socioeconomic disparities in childhood obesity that provide training opportunities for mentees. The first two aims of this application focus on two R01-funded cluster randomized-controlled trials (CRTs) examining the impact of drinking water promotion and access on children’s intake of water and sugar-sweetened beverages, and obesity in elementary schools (Water First, n=1249 students) and childcare centers (Healthy Drinks, Healthy Futures, n=420 children).This K24 award will leverage these two trials by applying the RE-AIM framework to examine the interventions’ reach, effectiveness, adoption, implementation, cost, and maintenance. The Specific Aims are to: 1) Estimate the short-term cost, population reach and effectiveness of Water First and Heathy Drinks, Healthy Futures interventions in increasing water intake, decreasing SSB intake, and preventing overweight, 2) Examine the impact of the interventions among different subgroups (by age, sex, racial/ethnic background, English proficiency and acculturation level), and 3) Describe how the impact of the interventions differ by fidelity to the intervention implementation strategies. These data will be used to translate evidence into practice and adapt the interventions for “real-world” settings. The research will also provide a platform for training experiences in conduct of CRTs, community-engaged research, dissemination and implementation science, intervention development, mixed methods, dietary assessment, and statistical analysis. The award will also allow Dr. Patel to expand her mentoring of early stage clinical investigators pursing translational POR and support her own career development in 1) gaining and applying mentorship and leadership skills, 2) building novel research with multi-disciplinary investigators, and 3) fostering new research expertise in dissemination and implementation research and economic evaluation at an opportune time in her career.