Mentoring in Translational Research to Prevent Disparities in Childhood Obesity and Cardiometabolic Disease

项目概要/摘要 博士Anisha Patel是斯坦福大学的一名职业中期儿科医生兼研究员，她正在申请K24职业中期研究员 患者导向研究奖（POR）。Patel博士在研究方面（公共卫生、健康 服务研究、社区参与研究、卫生政策）。她建立了一个创新的研究项目， 利用社区-学术-政策伙伴关系，防止种族/民族和收入相关的差距 肥胖症和心脏代谢疾病的研究，由联邦机构、基金会和机构支持资助。 她还在POR中有着广泛的指导历史，特别强调学员 在卫生领域任职人数不足。作为斯坦福大学的儿科副教授， 作为斯坦福大学妇幼健康研究的社区卫生研究主任 研究所，帕特尔博士准备指导早期和初级临床研究人员在转化科学。帕特尔医生 正在进行许多社区参与的研究，以防止种族/民族和社会经济不平等， 儿童肥胖，为学员提供培训机会。本申请的前两个目标集中于 两项由R 01资助的随机对照试验（CRT）检查了饮用水推广的影响 儿童饮水和含糖饮料的摄入量以及小学肥胖问题 （水第一，n=1249名学生）和托儿中心（健康饮料，健康未来，n=420名儿童）。 K24奖将通过应用RE-AIM框架来检查干预措施， 覆盖范围、有效性、采用率、实施、成本和维护。具体目标是：（1）估计 水第一和健康饮料，健康未来的短期成本，人口覆盖率和有效性 增加水摄入量，减少SSB摄入量和预防超重的干预措施，2）检查 干预措施在不同亚组中的影响（按年龄、性别、种族/民族背景、英语 熟练程度和文化适应水平），以及3）描述干预措施的影响如何因对 干预实施战略。这些数据将用于将证据转化为实践， 在“真实世界”中的干预。这项研究还将提供一个平台， 社区参与研究、传播和实施科学、干预 发展，混合方法，饮食评估和统计分析。该奖项还将允许帕特尔博士 扩大她对追求翻译POR的早期临床研究者的指导，并支持她自己的 职业发展：1）获得和运用导师和领导技能，2）建立新的研究， 多学科研究人员，以及3）培养传播和实施方面的新的研究专门知识 研究和经济评估在她的职业生涯的一个适当的时候。

PROJECT SUMMARY/ABSTRACT Dr. Anisha Patel is a midcareer pediatrician-researcher at Stanford applying for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR). Dr. Patel has excellent training in research (public health, health services research, community-engaged research, health policy). She has built an innovative research program that leverages community-academic-policy partnerships to prevent racial/ethnic and income-related disparities in obesity and cardiometabolic diseases funded by federal agencies, foundations, and institutional support. She also has an extensive history of mentoring in POR, with a particular emphasis on trainees underrepresented in health fields. As Associate Professor of Pediatrics at Stanford in many formal mentoring roles and as Director of Community-Engaged Research in Stanford’s Maternal and Child Health Research Institute, Dr. Patel is poised to mentor early and junior clinician-investigators in translational science. Dr. Patel is conducting numerous community-engaged studies to prevent racial/ethnic and socioeconomic disparities in childhood obesity that provide training opportunities for mentees. The first two aims of this application focus on two R01-funded cluster randomized-controlled trials (CRTs) examining the impact of drinking water promotion and access on children’s intake of water and sugar-sweetened beverages, and obesity in elementary schools (Water First, n=1249 students) and childcare centers (Healthy Drinks, Healthy Futures, n=420 children).This K24 award will leverage these two trials by applying the RE-AIM framework to examine the interventions’ reach, effectiveness, adoption, implementation, cost, and maintenance. The Specific Aims are to: 1) Estimate the short-term cost, population reach and effectiveness of Water First and Heathy Drinks, Healthy Futures interventions in increasing water intake, decreasing SSB intake, and preventing overweight, 2) Examine the impact of the interventions among different subgroups (by age, sex, racial/ethnic background, English proficiency and acculturation level), and 3) Describe how the impact of the interventions differ by fidelity to the intervention implementation strategies. These data will be used to translate evidence into practice and adapt the interventions for “real-world” settings. The research will also provide a platform for training experiences in conduct of CRTs, community-engaged research, dissemination and implementation science, intervention development, mixed methods, dietary assessment, and statistical analysis. The award will also allow Dr. Patel to expand her mentoring of early stage clinical investigators pursing translational POR and support her own career development in 1) gaining and applying mentorship and leadership skills, 2) building novel research with multi-disciplinary investigators, and 3) fostering new research expertise in dissemination and implementation research and economic evaluation at an opportune time in her career.