HIV CENTERS FOR UNDEREPRESENTED POPULATIONS IN RESEARCH CTU (HIV CURE CTU) Administrative Supplement

CTU 弱势群体艾滋病毒研究中心 (HIV CURE CTU) 行政补充

• 批准号: 10166548
• 负责人: STEPHEN A SPECTOR
• 金额: $ 30.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-13 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166548
• 关键词: 2019-nCoV; Address; Administrative Supplement; Affect; Age; Antibody Response; Area; COVID-19; COVID-19 pandemic; Caring; Cessation of life; Characteristics; Child; Chronic lung disease; Color; Communities; Country; County; Diabetes Mellitus; Disease; Economics; Elderly; Enrollment; Epidemic; Evaluation; Family; Future; General Population; HIV; HIV Infections; Health; Health Policy; Healthcare; High Prevalence; Hypertension; Immunity; Immunologic Deficiency Syndromes; Immunologics; Individual; Industry; Infection; Medicaid; Medical; Mental Health; Morbidity - disease rate; Occupations; Outcome; Participant; Pediatric Hospitals; Persons; Population; Poverty; Public Health; Quarantine; Research; SARS coronavirus; Schools; Serologic tests; Services; Social Distance; Social isolation; Surveys; Symptoms; Testing; Texas; Time; Unemployment; Uninsured; United States; Virus; Virus Diseases; Vulnerable Populations; Work; Youth; co-infection; cohort; comorbidity; effective therapy; experience; follow-up; food insecurity; health economics; human old age (65+); improved; novel coronavirus; pandemic disease; safety net; socioeconomics

Project Summary: COVID-19 is a disease caused by SARS CoV-2 virus, a novel coronavirus that has caused a pandemic due to lack of immunity to the virus in the general population and lack of effective therapy. Increased morbidity due to COVID-19 disease occurs in people age 65 years old and older, persons with hypertension, diabetes, chronic lung disease, and with immunodeficiency. COVID-19 disease has greatly impacted persons of color in the United States due to a high prevalence of comorbidities in persons of color and due to relative lack of access to medical care in persons of color, especially in areas of the country most impacted by poverty and lack of Medicaid expansion, such as some Southern states in the US, like Texas, which has the one of the highest rates of uninsured individuals in the country. Texas currently has had 45,198 cases of COVID-19 with 1,272 fatalities. Harris County/Houston has had 9,050 combined confirmed cases with 199 deaths. The COVID-19 pandemic coincides with the HIV pandemic currently impacting the US and both SARS CoV-2 and HIV cause high morbidity in Communities of Color. Aside from the impact of both viral infections, the socioeconomic and mental health impacts of the public health approach to controlling the spread of COVID-19 disease, social distancing, quarantine, and isolation, have detrimentally impacted persons with HIV over and above the effects on the general population. Mental health problems, poverty, food insecurity, economic vulnerability, work in service industry where jobs have been eliminated, and lack of safety net for children out of school, all disproportionately affect persons with HIV. The Texas Children's Hospital (TCH) proposal will address the impact of COVID-19 in children and youth living with HIV in the Houston area. TCH will evaluate for prevalent SARS CoV-2 infection by performing a PCR evaluation at baseline and in 6 months in 160 children and youth ages 2 to 24 years who receive care at TCH. Serology for SARS CoV-2 will also be evaluated at baseline and in 6 months to look for evolving immunity over time in this population. Surveys will be administered at baseline and 6 months to evaluate for the socioeconomic and mental health impact of social distancing on these families and youth. COVID-19 disease in persons with HIV infection will be described. Baseline and follow-up demographic, immunologic, socioeconomic, and mental health characteristics of the children and youth enrolled living with HIV will be described.

项目概要： COVID-19 是由 SARS CoV-2 病毒引起的疾病，这是一种新型冠状病毒，已引起 由于普通人群对病毒缺乏免疫力，且缺乏有效的治疗措施，导致大流行 治疗。 65 岁以下人群因 COVID-19 疾病发病率增加 老年人、患有高血压、糖尿病、慢性肺病和免疫缺陷的人。 由于高感染率，COVID-19 疾病对美国有色人种产生了极大影响。 有色人种由于相对缺乏医疗机会而普遍患有合并症 对有色人种的照顾，特别是在该国受贫困和缺乏资源影响最严重的地区 医疗补助扩张，例如美国的一些南部州，例如德克萨斯州，该州拥有以下之一 该国未参保个人比例最高。德克萨斯州目前有 45,198 例病例 COVID-19 造成 1,272 人死亡。哈里斯县/休斯顿共有 9,050 人确诊 病例已达 199 人死亡。 COVID-19 大流行与目前影响美国的 HIV 大流行同时发生 SARS CoV-2 和 HIV 在有色人种社区中造成高发病率。除了影响 病毒感染、公共卫生方法对社会经济和心理健康的影响 为了控制 COVID-19 疾病的传播、保持社交距离、隔离和隔离， 对艾滋病毒感染者的不利影响超出了对普通人群的影响。 心理健康问题、贫困、粮食不安全、经济脆弱性、服务业 就业岗位被取消的行业，以及失学儿童缺乏安全网，所有这些 对艾滋病毒感染者的影响尤为严重。 德克萨斯儿童医院 (TCH) 提案将解决 COVID-19 对儿童的影响 以及休斯顿地区感染艾滋病毒的青少年。 TCH 将评估流行的 SARS CoV-2 通过在基线和 6 个月内对 160 名儿童和青少年进行 PCR 评估来评估感染情况 年龄在 2 岁至 24 岁之间、在 TCH 接受护理的人。 SARS CoV-2 的血清学也将进行评估 在基线和 6 个月内寻找该人群中随着时间的推移而演变的免疫力。调查 将在基线和 6 个月内进行管理，以评估社会经济和心理状况 社交距离对这些家庭和青少年的健康影响。人中的 COVID-19 疾病 将描述HIV感染。基线和随访人口统计学、免疫学、 登记居住的儿童和青少年的社会经济和心理健康特征 将描述HIV。