CTU COVID Testing Supplement

CTU 新冠病毒检测补充资料

• 批准号: 10166198
• 负责人: Jeffrey Lennox
• 金额: $ 59.99万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-16 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166198
• 关键词: 2019-nCoV; African American; Age; Area; COVID-19; COVID-19 pandemic; Caring; Case Study; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Cities; Clinic; Clinical; Clinical Trials Unit; Communities; Contact Tracing; Coronavirus; Country; County; Data; Diabetes Mellitus; Faculty; HIV; Hospitals; Hypertension; Individual; Infection; Lead; Measures; Medical; Obesity; Outcome; Participant; Patients; Persons; Population; Prevention; Quarantine; Reporting; Research; Research Infrastructure; Research Personnel; Safety; Severe Acute Respiratory Syndrome; Site; Social Distance; Testing; Universities; Vaccines; Virus; clinical research site; co-infection; comorbidity; coronavirus disease; effective therapy; face mask; high risk; interest; mHealth; metropolitan; pandemic disease; patient population; scale up

Emory-CDC Clinical Trials Unit-Supplement for COVID-19 testing Project Summary/Abstract The emerging COVID-19 pandemic, caused by the SARS-Co-V-2 coronavirus has already caused over 1.3 million infections and over 80,000 deaths in the US as of May 13, 2020 (1). In the absence of effective therapies or a vaccine, non-pharmacologic measures such as social distancing, face masks and lockdowns have been implemented for prevention of COVID-19 infection which has helped to decrease the spread. Additional critical measures to control the pandemic include identification and isolation of infected individuals and contact tracing which requires scaling up of testing for all people. As of May 13, 2020, the US has been able to perform ~ 9 million tests, or around 29,000 tests/million population. While this is a large number and, in fact, more tests performed than any other country in the world, it is still not sufficient. Several investigators suggest that 3 – 4 million tests/week are needed in order to test ~ 1% of the US population. Atlanta, Georgia has not been spared by the COVID-19 pandemic. While these is no data available for City of Atlanta, the 5 counties that form the Atlanta metropolitan area (Fulton, DeKalb, Gwinnett, Clayton and Cobb) have reported 11,771 cases which represents 34% of the total cases reported in the State of Georgia (2). The characteristics and clinical outcomes of hospitalized patients with COVID-19 in Georgia have been recently described (3). Among 305 patients, the median age was 60 years with 29% of the patients under the age of 50. Also, 83% were African American and although co-morbid conditions such as diabetes, obesity and hypertension were common, 1 in 4 patients admitted did not have any high-risk conditions. In a study among COVID-19 patients in three hospitals where Emory University faculty provide medical care, 20 of 530 persons had HIV co-infection. Median age was 57 years, most had controlled HIV and comorbid condition such as hypertension and diabetes. The Emory-CDC HIV Clinical Trials Unit has two Clinical Research Sites in Atlanta, the Hope Clinic of the Emory Vaccine Center and the Ponce de Leon Clinic. Both sites offer great opportunities to expand testing, not only to their existing patient populations but also to the neighboring communities. In this application we propose to use the existing infrastructure for research and will add expanded facilities for COVID-19 testing. Since testing for COVID-19 must incorporate safety measures for the staff, we plan to develop expanded facilities including temporary tents to accommodate potential drive through scenarios, and/or a mobile health clinic.

Emory-CDC 临床试验单元针对 COVID-19 检测的补充 项目概要/摘要 由 SARS-Co-V-2 冠状病毒引起的新出现的 COVID-19 大流行已导致超过 1.3 截至 2020 年 5 月 13 日，美国已有 100 万人感染，超过 8 万人死亡 (1)。在缺乏有效措施的情况下 疗法或疫苗、非药物措施，例如社交距离、口罩和封锁 已实施预防 COVID-19 感染，这有助于减少传播。 控制大流行的其他关键措施包括识别和隔离感染者 接触者追踪需要扩大对所有人的测试范围。截至2020年5月13日，美国 能够执行约 900 万次测试，或每百万人口约 29,000 次测试。虽然这是一个很大的数字，而且在 事实上，尽管进行的测试比世界上任何其他国家都多，但仍然不够。多名调查人员 建议每周需要 3 – 400 万次测试才能测试约 1% 的美国人口。 佐治亚州亚特兰大也未能幸免于 COVID-19 大流行。虽然这些城市没有可用的数据 亚特兰大，构成亚特兰大都会区的 5 个县（富尔顿、迪卡尔布、格温内特、克莱顿和科布） 报告了 11,771 例病例，占佐治亚州报告病例总数的 34% (2)。这 最近，乔治亚州住院的 COVID-19 患者的特征和临床结果 描述（3）。在 305 名患者中，中位年龄为 60 岁，其中 29% 的患者年龄在 50 岁以下。 此外，83% 是非裔美国人，尽管患有糖尿病、肥胖症和 高血压很常见，四分之一的入院患者没有任何高危病症。在一项研究中 埃默里大学教职人员提供医疗服务的三家医院的 COVID-19 患者，共 530 人，其中有 20 人 合并感染艾滋病毒。中位年龄为 57 岁，大多数人已控制艾滋病毒和合并症，例如 高血压和糖尿病。 埃默里大学疾病预防控制中心艾滋病毒临床试验中心在亚特兰大有两个临床研究中心，即希望诊所 埃默里疫苗中心和庞塞德莱昂诊所。这两个站点都提供了扩大测试的绝佳机会， 不仅针对现有的患者群体，还针对邻近社区。在这个应用程序中我们 建议使用现有基础设施进行研究，并将增加用于 COVID-19 测试的扩展设施。 由于 COVID-19 检测必须纳入工作人员的安全措施，因此我们计划开发更广泛的 设施，包括临时帐篷，以适应潜在的驾车穿越场景和/或移动医疗 诊所。