CTU COVID Testing Supplement

CTU 新冠病毒检测补充资料

• 批准号: 10166198
• 负责人: Jeffrey Lennox
• 金额: $ 59.99万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-16 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166198
• 关键词: 2019-nCoV; African American; Age; Area; COVID-19; COVID-19 pandemic; Caring; Case Study; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Cities; Clinic; Clinical; Clinical Trials Unit; Communities; Contact Tracing; Coronavirus; Country; County; Data; Diabetes Mellitus; Faculty; HIV; Hospitals; Hypertension; Individual; Infection; Lead; Measures; Medical; Obesity; Outcome; Participant; Patients; Persons; Population; Prevention; Quarantine; Reporting; Research; Research Infrastructure; Research Personnel; Safety; Severe Acute Respiratory Syndrome; Site; Social Distance; Testing; Universities; Vaccines; Virus; clinical research site; co-infection; comorbidity; coronavirus disease; effective therapy; face mask; high risk; interest; mHealth; metropolitan; pandemic disease; patient population; scale up

Emory-CDC Clinical Trials Unit-Supplement for COVID-19 testing Project Summary/Abstract The emerging COVID-19 pandemic, caused by the SARS-Co-V-2 coronavirus has already caused over 1.3 million infections and over 80,000 deaths in the US as of May 13, 2020 (1). In the absence of effective therapies or a vaccine, non-pharmacologic measures such as social distancing, face masks and lockdowns have been implemented for prevention of COVID-19 infection which has helped to decrease the spread. Additional critical measures to control the pandemic include identification and isolation of infected individuals and contact tracing which requires scaling up of testing for all people. As of May 13, 2020, the US has been able to perform ~ 9 million tests, or around 29,000 tests/million population. While this is a large number and, in fact, more tests performed than any other country in the world, it is still not sufficient. Several investigators suggest that 3 – 4 million tests/week are needed in order to test ~ 1% of the US population. Atlanta, Georgia has not been spared by the COVID-19 pandemic. While these is no data available for City of Atlanta, the 5 counties that form the Atlanta metropolitan area (Fulton, DeKalb, Gwinnett, Clayton and Cobb) have reported 11,771 cases which represents 34% of the total cases reported in the State of Georgia (2). The characteristics and clinical outcomes of hospitalized patients with COVID-19 in Georgia have been recently described (3). Among 305 patients, the median age was 60 years with 29% of the patients under the age of 50. Also, 83% were African American and although co-morbid conditions such as diabetes, obesity and hypertension were common, 1 in 4 patients admitted did not have any high-risk conditions. In a study among COVID-19 patients in three hospitals where Emory University faculty provide medical care, 20 of 530 persons had HIV co-infection. Median age was 57 years, most had controlled HIV and comorbid condition such as hypertension and diabetes. The Emory-CDC HIV Clinical Trials Unit has two Clinical Research Sites in Atlanta, the Hope Clinic of the Emory Vaccine Center and the Ponce de Leon Clinic. Both sites offer great opportunities to expand testing, not only to their existing patient populations but also to the neighboring communities. In this application we propose to use the existing infrastructure for research and will add expanded facilities for COVID-19 testing. Since testing for COVID-19 must incorporate safety measures for the staff, we plan to develop expanded facilities including temporary tents to accommodate potential drive through scenarios, and/or a mobile health clinic.

Emory-CDC临床试验单元-COVID-19检测补充 项目总结/摘要 由SARS-Co-V-2冠状病毒引起的新型COVID-19大流行已经造成超过1.3 截至2020年5月13日，美国有超过80，000人感染，超过80，000人死亡（1）。如果缺乏有效的 治疗或疫苗，非药物措施，如社交距离，口罩和封锁 为预防COVID-19感染而实施，有助减少传播。 控制这一流行病的其他关键措施包括识别和隔离受感染者 和接触者追踪，这需要扩大对所有人的检测。截至2020年5月13日，美国已 能够进行约900万次测试，或约29，000次测试/百万人口。虽然这是一个很大的数字， 事实上，比世界上任何其他国家进行更多的测试，它仍然是不够的。几名研究者 建议每周需要3 - 4百万次测试，以测试约1%的美国人口。 格鲁吉亚亚特兰大也未能幸免于COVID-19大流行。虽然这些都是没有数据可用于城市的 亚特兰大，形成亚特兰大大都市区的5个县（富尔顿、迪卡尔布、格温内特、克莱顿和科布） 报告了11，771例病例，占格鲁吉亚州报告病例总数的34%（2）。的 最近，格鲁吉亚住院的COVID-19患者的特征和临床结局已被 描述（3）。在305例患者中，中位年龄为60岁，29%的患者年龄小于50岁。 此外，83%的人是非洲裔美国人，尽管他们患有糖尿病、肥胖症和 高血压是常见的，1/4的入院患者没有任何高危情况。在一项研究中 埃默里大学教师提供医疗护理的三家医院的COVID-19患者，530人中有20人 同时感染艾滋病病毒。中位年龄为57岁，大多数已控制艾滋病毒和共病状况，如 高血压和糖尿病。 Emory-CDC HIV临床试验部门在亚特兰大有两个临床研究中心， 埃默里疫苗中心和庞塞德莱昂诊所。这两个网站都提供了很好的机会来扩大测试， 不仅对现有的病人群体，而且对邻近的社区。在本申请中，我们 建议使用现有的基础设施进行研究，并将增加新冠病毒检测设施。 由于COVID-19检测必须包括员工的安全措施，我们计划开发扩大的 设施，包括临时帐篷，以适应潜在的驱动器通过场景，和/或移动的健康 诊所