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Assessing the effects of adolescent nicotine vapor exposure on motivation and decision for rewards

评估青少年尼古丁蒸气暴露对奖励动机和决策的影响

基本信息

批准号：
10172762
负责人：
Ian Alfredo Mendez
金额：
$ 12万
依托单位：
UNIVERSITY OF TEXAS EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10172762
关键词：
Acute Address Adolescence Adolescent Adolescent and Young Adult Adult Advertising Animal Model Automobile Driving Behavior Behavioral Brain Chemicals Chemosensitization Chronic Cigarette Cognitive Consumption Corpus striatum structure Costs and Benefits Cues Data Decision Making Development Drug usage Electronic Nicotine Delivery Systems Electronic cigarette Environmental Risk Factor Female Food Foundations Future Genetic Glycerol Goals Health Hippocampus (Brain)Human Impulsive Behavior Impulsivity Infusion procedures Inhalation Injections Knowledge Long-Term Effects Lung Measures Mental Health Motivation Neurobiology Nicotine Nicotinic Receptors Palate Particle Size Pharmacodynamics Policies Population Prefrontal Cortex Propylene Glycols Rattus Recording of previous events Research Research Priority Rewards Risk Risk Behaviors Safety Sales System Techniques Testing Vegetables absorption addiction adolescent health base behavioral phenotyping brain behavior cholinergic cigarette smoking cost shifting discounting drug of abuse electronic cigarette use experimental study improved injection/infusion male neurobiological mechanism nicotine exposure nicotine use nicotine vapor novel preclinical study receptor tobacco products trend vaping

项目摘要

Project Summary A lack of information, along with targeted advertising, addition of palatable flavors, and misconceptions about their safety has led to a dramatic increase in the use of electronic nicotine delivery systems (e-cigarettes), with sales of e-cigarettes rising from $20 million in 2008 to $1.5 billion in 2014. In adolescents, continuing annual increases in e-cigarette use have been particularly high and e-cigarette use has now surpassed that of traditional cigarettes within this population. The neurobiology of the adolescent brain produces a behavioral phenotype that increases reward-seeking behavior and makes them engage in more impulsive and risky behaviors, including experimental drug use. These findings warrant a critical need for more research on the effects of nicotine vapor exposure on adolescent health, including its effects on the malleable adolescent brain and the behavior that it controls. We posit that adolescent exposure to nicotine vapor results in long-term dramatic changes in reward seeking behaviors. Based on the results of a limited number of studies investigating the effects of nicotine on decision making and cue-induced motivation for rewards, we predicted that repeated exposure to nicotine vapor will cause a significant and persist increases in impulsive choice, decreases in risky choice, and decreases in cue-induced potentiation of reward seeking behavior, in both male and female rats. Additionally, we expect that specific nicotinic receptor subtypes, particularly within the striatum, will predict reward choice and motivation. We will test these predictions using cost-benefit decision making and Pavlovian- to-instrumental transfer tests with food pellets as the reward. The goal of this research is to determine if exposure to nicotine vapor during adolescence causes significant long-term changes in impulsive or risky choice (Aim 1a) or long-term changes in the ability of reward paired cues to invigorate reward seeking behavior (Aim 1b). Additionally, relationships between reward motivation or reward choice and nicotinic α4β2 receptor levels in the brains of rats, with and without a history or adolescent nicotine vapor exposure, will be determined (Aim 2). This research will provide immediate and much needed information about this rising and potentially devastating addictive trend, commonly observed in adolescents.

项目总结