CAMPO Global Cancer Health Disparities Supplement
CAMPO 全球癌症健康差异补充资料
基本信息
- 批准号:10166395
- 负责人:
- 金额:$ 19.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-12 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithmsAnusBiopsyButyratesCaliforniaCervicalCitiesClassificationClinicClinical DataCytologyDataDetectionDevelopmentDiagnosisDiagnostic testsDietDietary intakeDiseaseEducationEnrollmentFoodFrequenciesFutureGenesGeneticGenomic DNAGoalsHIVHIV SeropositivityHispanicsHuman Papilloma Virus-Related Malignant NeoplasmHuman PapillomavirusHuman papilloma virus infectionIncidenceInflammatoryInfrastructureLatin AmericaLife StyleLightLocationMalignant NeoplasmsMalignant neoplasm of anusMeasurementMediatingMethylationMexicanMexicoNeoplasmsOncoproteinsOutcomeParentsParticipantPhasePopulationPreventionProbioticsPuerto RicoQuestionnairesRegimenResearchResolutionRiskRoleSan FranciscoSiteSpecimenSquamous intraepithelial lesionSwabTestingTimeWomanbiobankcancer health disparitycancer riskcervical and anal cancerclinical caredesignhigh riskhigh risk populationinterestmenmen who have sex with menmicrobiomemicrobiome analysismicrobiotamicrobiota profilesnovel therapeuticsparent grantrandom forestrecruitresponsescreeningsexsociodemographicstherapeutic vaccine
项目摘要
Abstract
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as
NOT-CA-20-032. This is a supplement to U54 CA242646, “California-Mexico-Puerto Rico Partnership
(CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations”. The parent grant's focus is to
perform research on reducing the risk of cervical and anal cancer in men and women living with HIV in Latin
America. CAMPO Study 1 will enroll 4000 women and 1000 men living with HIV to optimize screening
algorithms to detect cervical and anal high-grade squamous intraepithelial lesions (HSIL). The incidence of
anal cancer is high among all groups of Hispanic people living with HIV (PLWH), especially among those in
Puerto Rico (PR). HPV infection is necessary but insufficient for the development of anal HSIL and cancer. The
goal of this supplement is to elucidate the role of the anal microbiome as a contributor to this increased risk of
anal cancer risk in these high-risk populations. Specific aims are 1) Study the relationship between anal high-
risk HPV (hr-HPV) infection and the anal microbiome among three distinct populations of Hispanic PLWH in
California, Mexico and PR; and 2) Study the relationship between anal HSIL and the anal microbiome among
three distinct populations of Hispanic PLWH with anal hr-HPV infection. These populations are of particular
interest given their divergent lifestyles but similarity in genetic background. We hypothesize that among
Hispanic PLWH without anal HSIL, the microbiome will be different among those with and without hr-HPV
infection. We hypothesize that the proportion with pro-inflammatory-mediating taxa will be highest among the
PR population compared with the Mexican and California populations given the higher incidence in anal cancer
in PR. We also hypothesize that among Hispanic PLWH with anal hr-HPV at the 3 locations, detection of HSIL
will be associated with a pro-inflammatory microbiome and a decrease in butyrate-producing signatures, with
the proportion with pro-inflammatory changes highest in PR compared with the other populations.
We will enroll 100 PLWH (50 men and 50 women) at each of the PR, Mexico City and San Francisco
CAMPO sites, for a total of 300 Hispanic PLWH. Data on anal HPV, anal cytology and anal HSIL will be
available through CAMPO Study 1 in PR and Mexico City, and from the San Francisco ANCRE Clinic, where
PLWH are screened for anal HSIL as part of routine clinical care. A validated food frequency questionnaire in
Spanish will be administered to assess dietary intake for the previous 3 and 6 months. Anal swab specimens
will be retrieved from the CAMPO Biorepository and used for microbiome analysis. The 16S gene will be
amplified from extracted anal swab genomic DNA and subjected to Illumina Miseq. Sequences of the 16S gene
V4 region will be analyzed in QIIME2. Random forest classification will be performed to understand how our
predictors, i.e. microbiome variables (diversity measurements, species-level taxa) and other covariates
(sociodemographics, sex, diet, clinical data, etc.), are associated with hr-HPV infection or HSIL (outcomes).
摘要
本申请是为了响应特别利益通知(NOSI)而提交的,该通知被确定为
NOT-CA-20-032。这是对U 54 CA 242646“加利福尼亚-墨西哥-波多黎各伙伴关系”的补充
(CAMPO)预防HIV+人群中HPV相关癌症中心。家长补助金的重点是
研究如何降低艾滋病毒感染者患宫颈癌和肛门癌的风险
美国参考CAMPO研究1将招募4000名女性和1000名男性艾滋病毒感染者,以优化筛查
检测宫颈和肛门高度鳞状上皮内病变(HSIL)的算法。的发生率
肛门癌在所有西班牙裔艾滋病毒感染者(PLWH)群体中都很高,特别是在
波多黎各(PR). HPV感染是必要的,但不足以发展肛门HSIL和癌症。的
这种补充的目的是阐明肛门微生物组作为这种增加的风险的贡献者的作用。
这些高危人群的肛门癌风险。具体目的是:1)研究肛门高血压与糖尿病的关系;
高危型HPV(hr-HPV)感染和肛门微生物组在西班牙裔PLWH的三个不同人群中,
加州、墨西哥和PR; 2)研究肛门HSIL与肛门微生物组之间的关系,
三个不同的西班牙裔PLWH人群与肛门hr-HPV感染。这些人群特别
他们的生活方式不同,但遗传背景相似。我们假设,
没有肛门HSIL的西班牙裔PLWH,微生物组在有和没有hr-HPV的人之间是不同的
感染我们推测,促炎介导分类群的比例将是最高的,
PR人群与墨西哥和加州人群相比,肛门癌的发病率更高
我们还假设,在3个位置的肛门hr-HPV的西班牙裔PLWH中,
将与促炎微生物组和丁酸盐生成特征的减少有关,
与其他人群相比,PR中促炎性变化的比例最高。
我们将在PR、墨西哥城和旧金山弗朗西斯科各招募100名PLWH(50名男性和50名女性)
CAMPO网站,共300西班牙裔PLWH。肛门HPV、肛门细胞学和肛门HSIL的数据将在
可通过PR和墨西哥城的CAMPO研究1以及旧金山弗朗西斯科ANCRE诊所获得,
作为常规临床护理的一部分,对PLWH进行肛门HSIL筛查。一份经过验证的食物频率问卷,
将进行西班牙语评估,以评估过去3个月和6个月的饮食摄入量。肛门拭子标本
将从CAMPO生物储存库中取出并用于微生物组分析。16 S基因将是
从提取的肛门拭子基因组DNA中扩增并进行Illumina Miseq。16 S基因的序列
将在QIIME 2中分析V4区域。将执行随机森林分类,以了解我们的
预测因子,即微生物组变量(多样性测量,物种水平分类群)和其他协变量
(社会人口统计学、性别、饮食、临床数据等),与hr-HPV感染或HSIL(结局)相关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANA Patricia ORTIZ其他文献
ANA Patricia ORTIZ的其他文献
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{{ truncateString('ANA Patricia ORTIZ', 18)}}的其他基金
Characterization of the cervical fungal communities modulating high-risk HPV infections in Hispanic Women Living with HIV (WLWH)
调节西班牙裔女性 HIV 感染者 (WLWH) 高危 HPV 感染的宫颈真菌群落特征
- 批准号:
10533625 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Mechanisms of disparities in the natural history of oral and oropharyngeal HPV infection among persons living with HIV: the CAMPO oral cohort study
HIV 感染者口腔和口咽 HPV 感染自然史差异的机制:CAMPO 口腔队列研究
- 批准号:
10677502 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Cancer Prevention and Control (CAPAC) Research Training Program
癌症预防与控制 (CAPAC) 研究培训计划
- 批准号:
10681355 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
Cancer Prevention and Control (CAPAC) Research Training Program
癌症预防与控制 (CAPAC) 研究培训计划
- 批准号:
10405752 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
California-Mexico-Puerto Rico Partnership (CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations
加州-墨西哥-波多黎各伙伴关系 (CAMPO) 艾滋病毒人群中 HPV 相关癌症预防中心
- 批准号:
10411453 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
Cancer Prevention and Control (CAPAC) Research Training Program
癌症预防与控制 (CAPAC) 研究培训计划
- 批准号:
9791794 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
Cancer Prevention and Control (CAPAC) Research Training Program
癌症预防与控制 (CAPAC) 研究培训计划
- 批准号:
10478110 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
California-Mexico-Puerto Rico Partnership (CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations
加州-墨西哥-波多黎各伙伴关系 (CAMPO) 艾滋病毒人群中 HPV 相关癌症预防中心
- 批准号:
10737846 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
Cervical Cancer, Aging, and Psychological Distress among HIV-positive Women in Mexico and Puerto Rico: An exploratory sub-study of the CAMPO Consortium Clinical Trials Program
墨西哥和波多黎各艾滋病毒阳性女性的宫颈癌、衰老和心理困扰:CAMPO 联盟临床试验计划的探索性子研究
- 批准号:
10310982 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
California-Mexico-Puerto Rico Partnership (CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations
加州-墨西哥-波多黎各伙伴关系 (CAMPO) 艾滋病毒人群中 HPV 相关癌症预防中心
- 批准号:
10469352 - 财政年份:2019
- 资助金额:
$ 19.49万 - 项目类别:
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