Cleveland Alzheimer's Disease Research Center

克利夫兰阿尔茨海默病研究中心

• 批准号: 10170038
• 负责人: JAMES Bruce LEVERENZ
• 金额: $ 36.86万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170038
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Clinic; Clinical; Clinical Research; Cognitive; Collection; Communities; Country; Databases; Dementia; Disease; Evaluation; Foundations; Funding; Health system; Healthcare; Heterogeneity; Image; Individual; Infrastructure; International; Lewy Body Dementia; Magnetic Resonance Imaging; Medical; Medical center; Minority Enrollment; National Institute on Aging; Nevada; Ohio; Participant; Pathologic; Pathology; Persons; Phenotype; Physicians; Population; Prion Diseases; Protocols documentation; Research; Research Personnel; Sampling; Science; Speed; Standardization; Structure; United States National Institutes of Health; Universities; University Hospitals; amyloid imaging; amyloid pathology; amyloid structure; improved; mild cognitive impairment; neuroimaging; programs; recruit

OVERALL PROJECT SUMMARY The Cleveland Alzheimer’s Disease Research Center (CADRC) is a collaborative effort amongst physicians and investigators from Case Western Reserve University (CWRU), the Cleveland Clinic Foundation (CCF), the Metro Health System (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSVA), to establish a National Institute on Aging (NIA) funded Alzheimer’s disease research center. The CADRC would represent a rich clinical and research community and an estimated 220,000 Ohioans who suffer from Alzheimer’s disease (AD). Currently there is no Alzheimer’s Disease Research Center in Ohio. The CADRC will bring together the considerable expertise from the medical and academic communities in northeast Ohio to focus on one of the largest health care crises facing our country. The CADRC will be focused on the increasingly recognized clinical and pathologic heterogeneity observed in AD and AD-Related Dementias (ADRD). The CADRC will create an infrastructure to help speed up the research efforts of local, national and international investigators. The CADRC will participate in the national Alzheimer’s Centers program and contribute to the “big science” possible when centers from around the country collaborate. We will recruit subject samples that northeast Ohio is well situated to study due to unique regional populations or studies (dementia with Lewy bodies and rapidly progressive AD identified by the National Prion Disease Pathology Surveillance Center,) or relevant to our understanding of AD and related dementias (cognitively normal older individuals, AD and mild cognitive impairment). We will add value to the evaluation of these subject samples by adding biofluid collection and analysis and cutting edge imaging. Special emphasis will also be placed on enrollment of minority populations not often well-studied. We are quite encouraged by the collaborative spirit already demonstrated by those participating in the CADRC planning from CWRU, CCF, MHS, UH, and LSVA and from the support we have received from the northeast Ohio community. We believe this is a great opportunity for Ohio to contribute to the greater efforts of the Alzheimer’s Disease Research Centers program and to improve the treatments for these devastating disorders.

全面的 项目概要 克利夫兰阿尔茨海默病研究中心 (CADRC) 是以下机构的共同努力成果： 来自凯斯西储大学 (CWRU)、克利夫兰诊所基金会的医生和研究人员 (CCF)、大都会医疗系统 (MHS)、大学医院 (UH) 和 Louis Stokes Cleveland VA Medical 中心（LSVA），建立国家老龄化研究所（NIA）资助的阿尔茨海默病研究中心。这 CADRC 将代表一个丰富的临床和研究社区以及估计有 220,000 名患有此病的俄亥俄州人 来自阿尔茨海默病（AD）。目前俄亥俄州没有阿尔茨海默病研究中心。 CADRC 将汇集医学界和学术界的大量专业知识 在俄亥俄州东北部，重点关注我国面临的最大的医疗保健危机之一。 CADRC将重点关注 在 AD 和 AD 相关痴呆中观察到的临床和病理异质性日益得到认可 （ADRD）。 CADRC 将创建一个基础设施，以帮助加快地方、国家和地区的研究工作 国际调查人员。 CADRC 将参与国家阿尔茨海默病中心计划 当全国各地的中心合作时，为“大科学”做出贡献。我们将招募受试者 由于独特的区域人口或研究（痴呆症），俄亥俄州东北部的样本非常适合研究 国家朊病毒病病理学监测发现具有路易体和快速进展性 AD 中心）或与我们对 AD 和相关痴呆症（认知正常的老年人，AD 和轻度认知障碍）。我们将通过添加生物流体来增加这些受试者样本的评估价值 收集和分析以及尖端成像。还将特别重视少数民族的入学 人群并不经常得到充分研究。 我们对参与者所表现出的合作精神感到非常鼓舞 来自 CWRU、CCF、MHS、UH 和 LSVA 的 CADRC 规划以及我们获得的支持 俄亥俄州东北部社区。我们相信，这是俄亥俄州为更大努力做出贡献的绝佳机会。 阿尔茨海默病研究中心计划，并改善这些破坏性疾病的治疗方法 失调。