Cleveland Alzheimer's Disease Research Center

克利夫兰阿尔茨海默病研究中心

• 批准号: 10170038
• 负责人: JAMES Bruce LEVERENZ
• 金额: $ 36.86万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170038
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Clinic; Clinical; Clinical Research; Cognitive; Collection; Communities; Country; Databases; Dementia; Disease; Evaluation; Foundations; Funding; Health system; Healthcare; Heterogeneity; Image; Individual; Infrastructure; International; Lewy Body Dementia; Magnetic Resonance Imaging; Medical; Medical center; Minority Enrollment; National Institute on Aging; Nevada; Ohio; Participant; Pathologic; Pathology; Persons; Phenotype; Physicians; Population; Prion Diseases; Protocols documentation; Research; Research Personnel; Sampling; Science; Speed; Standardization; Structure; United States National Institutes of Health; Universities; University Hospitals; amyloid imaging; amyloid pathology; amyloid structure; improved; mild cognitive impairment; neuroimaging; programs; recruit

OVERALL PROJECT SUMMARY The Cleveland Alzheimer’s Disease Research Center (CADRC) is a collaborative effort amongst physicians and investigators from Case Western Reserve University (CWRU), the Cleveland Clinic Foundation (CCF), the Metro Health System (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSVA), to establish a National Institute on Aging (NIA) funded Alzheimer’s disease research center. The CADRC would represent a rich clinical and research community and an estimated 220,000 Ohioans who suffer from Alzheimer’s disease (AD). Currently there is no Alzheimer’s Disease Research Center in Ohio. The CADRC will bring together the considerable expertise from the medical and academic communities in northeast Ohio to focus on one of the largest health care crises facing our country. The CADRC will be focused on the increasingly recognized clinical and pathologic heterogeneity observed in AD and AD-Related Dementias (ADRD). The CADRC will create an infrastructure to help speed up the research efforts of local, national and international investigators. The CADRC will participate in the national Alzheimer’s Centers program and contribute to the “big science” possible when centers from around the country collaborate. We will recruit subject samples that northeast Ohio is well situated to study due to unique regional populations or studies (dementia with Lewy bodies and rapidly progressive AD identified by the National Prion Disease Pathology Surveillance Center,) or relevant to our understanding of AD and related dementias (cognitively normal older individuals, AD and mild cognitive impairment). We will add value to the evaluation of these subject samples by adding biofluid collection and analysis and cutting edge imaging. Special emphasis will also be placed on enrollment of minority populations not often well-studied. We are quite encouraged by the collaborative spirit already demonstrated by those participating in the CADRC planning from CWRU, CCF, MHS, UH, and LSVA and from the support we have received from the northeast Ohio community. We believe this is a great opportunity for Ohio to contribute to the greater efforts of the Alzheimer’s Disease Research Centers program and to improve the treatments for these devastating disorders.

全面的 项目摘要 克利夫兰阿尔茨海默氏病研究中心（CADRC）是一项合作的努力 克利夫兰诊所基金会凯斯西部储备大学（CWRU）的医师和研究人员 （CCF），地铁卫生系统（MHS），大学医院（UH）和Louis Stokes Cleveland VA Medical 中心（LSVA），建立一个国家老化研究所（NIA）资助的阿尔茨海默氏病研究中心。这 CADRC将代表一个丰富的临床和研究社区，估计有22万 来自阿尔茨海默氏病（AD）。目前，俄亥俄州没有阿尔茨海默氏病研究中心。 CADRC将汇集医学和学术社区的大量专业知识 在俄亥俄州东北部，专注于我们国家面临的最大医疗危机之一。 CadRC将集中 在越来越公认的临床和病理异质性中，在AD和AD相关的痴呆症中观察到 （ADRD）。 CADRC将创建一个基础设施，以帮助加快本地，国家和 国际调查员。 CADRC将参加国家阿尔茨海默氏症中心计划和 当全国各地的中心合作时，为“大科学”做出了贡献。我们将招募主题 由于独特的区域人口或研究（痴呆症），俄亥俄州东北部的样本非常适合研究 由Lewy的身体和由国家病毒疾病病理监测确定的迅速进行的AD 中心）或与我们对AD和相关痴呆症的理解有关（认知正常的老年人，AD 和轻度认知障碍）。我们将通过添加生物流体来评估这些主题样本的价值 收集和分析以及最先进的成像。特别重点也将放在少数群体的入学率上 人口通常不经过充分研究。 我们的协作精神已经被参与的那些合作精神所表明了 来自CWRU，CCF，MHS，UH和LSVA的CADRC计划，以及我们从我们那里得到的支持。 俄亥俄州东北部社区。我们认为，这是俄亥俄州为更大努力做出贡献的绝佳机会 阿尔茨海默氏病研究中心计划，并改善这些毁灭性的治疗方法 疾病。