Administrative Core

行政核心

• 批准号: 10263708
• 负责人: JAMES Bruce LEVERENZ
• 金额: $ 49.2万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263708
• 关键词: Address; Administrator; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Biological Markers; Biology; COVID-19; Clinic; Clinical; Collaborations; Communities; Data; Dementia; Development; Disease Progression; Enrollment; Ensure; Faculty; Fostering; Foundations; Funding; Goals; Guidelines; Heterogeneity; Institution; Institutional Review Boards; International; Intervention; Lead; Medical; Medical center; Modification; Molecular; Monitor; Nerve Degeneration; Ohio; Pathologic; Process; Program Research Project Grants; Protocols documentation; Research; Research Personnel; Research Support; Risk Factors; Role; Sampling; Site; Students; System; Time; Training Programs; Training Support; Translating; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; University Hospitals; Veterans; Visit; Work; base; data exchange; data management; ethnic minority population; human subject; imaging biomarker; meetings; member; neuroimaging; neuropathology; outreach; prevent; programs; protective factors; racial minority; recruit; repository; statistics; success; transmission process

PROJECT SUMMARY The Cleveland Alzheimer's Disease Research Center (CADRC) is a collaborative effort of investigators at five Cleveland area institutions: Case Western Reserve University (CWRU), Cleveland Clinic Foundation (CCF), MetroHealth Systems (MHS), University Hospitals (UH), and the Louis Stokes Cleveland Veterans Affairs Medical Center (LSCVAMC). The Administrative Core (AC) of the CADRC has the overall responsibility for promoting the successful integration of the participating sites and investigators and the successful completion of the Center's goals. The AC works closely with the other cores to achieve the aims of the CADRC and milestones of the National Alzheimer's Project Act. In addition, the AC has a unique role in the CADRC of promoting close collaboration between CADRC investigators, Cores, local neurodegeneration research investigators, and local community leaders to foster an active center of Alzheimer's disease (AD) and AD- related dementias (ADRD).The AC has primary responsibility for coordinating and leading CADRC group activities including weekly AC/administrator meetings, monthly Core leaders meeting, the twice yearly Internal Advisory Committee (IAC) meetings, and annual External Advisory Committee (EAC) visits. These meetings review the activities and accomplishments of the cores, ensures timely transmission of CADRC data and biospecimens to the National Alzheimer's Coordinating Center (NACC) and National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), and fosters additional collaborations between cores (Specific Aim 1). The AC also provides external support and advice to the CADRC investigators on advancing the goals and aims of the center (Specific Aim 2) and promotes interactions with other Alzheimer Disease Research Centers, collaborations and opportunities for additional funding (Specific Aim 4). The AC provides compliance oversight and obtains/renews centralized institutional review board approval of CADRC activities (Specific Aim 3). Lastly, the AC oversees and promotes training and support to students, fellows, and junior faculty through the establishment of an annual Development Project Grant Program (Specific Aim 5).

项目摘要 克利夫兰阿尔茨海默病研究中心（CADRC）是一个研究人员的合作努力， 在克利夫兰地区的五个机构：凯斯西储大学（CWRU），克利夫兰诊所基金会 (CCF)，大都会健康系统（MHS），大学医院（UH）和路易斯斯托克斯克利夫兰退伍军人 事务医疗中心（LSCVAMC）。CADRC的行政核心（AC）全面负责 促进参与研究中心和研究者的成功整合， 实现中心的目标。AC与其他核心紧密合作，以实现CADRC的目标 和国家阿尔茨海默病项目法案的里程碑。此外，AC在CADRC中发挥着独特的作用， 促进CADRC研究人员、核心研究、当地神经退行性疾病研究之间的密切合作 研究人员和当地社区领导人，以促进阿尔茨海默病（AD）和AD- AC的主要职责是协调和领导CADRC小组 活动包括每周AC/管理员会议，每月核心领导人会议，每年两次内部会议 咨询委员会（IAC）会议和外部咨询委员会（EAC）年度访问。这些会议 审查各核心的活动和成果，确保CADRC数据的及时传输， 国家阿尔茨海默氏症协调中心（NACC）和国家集中储存库 阿尔茨海默病和相关痴呆症（NCRAD），并促进核心之间的额外合作 （具体目标1）。AC还为CADRC调查人员提供外部支持和建议， 该中心的目标和宗旨（具体目标2），并促进与其他阿尔茨海默病的互动 研究中心、合作和获得额外资金的机会（具体目标4）。AC提供 合规监督，并获得/更新中央机构审查委员会对CADRC活动的批准 （具体目标3）。最后，AC监督和促进培训和支持学生，研究员和初级 通过建立年度发展项目赠款计划（具体目标5）的教师。