UK-ADRC neuroimaging supplement: LATE and PART

项目摘要/摘要-总体(改编自《家长赠款摘要》，英国-ADC) 这是肯塔基大学阿尔茨海默病研究中心(UK-ADRC)的一份提案 神经影像补充剂。该附录的目的是提供英国-ADRC的神经成像数据 NIH最近资助的标准化集中式阿尔茨海默氏症的深度表型临床队列 及相关痴呆症的神经影像(扫描)。此外，本补编的次要目的是 确定两个AD模拟物的神经影像相关性：边缘为主的年龄相关性TDP-43脑病 (晚期)和原发年龄相关的肌张力障碍(部分)。英国-ADRC是一个经验丰富和合作的ADRC 最初是在1985年资助的。我们的主要使命是成为英国所有与AD相关的活动的联络人 以及美国的这一地区，通过提供一个环境和核心资源来催化创新 研究、推广、教育和临床项目。我们的标志性资源包括：1)认知正常 一组约500名受试者进行了纵向跟踪，所有人都在死亡时进行了脑部尸检；2)强大的 临床-神经病理相关性和短时间尸检计划；3)建立 使用神经影像和生物体液研究AD的临床前生物标记物的计划；4)集成的集中式 数据库和创新的生物统计学专门知识，以确定临床和生物转变的特征；以及5)a) 与非洲裔美国人社区建立了成功和密切的伙伴关系，并增加了 在我们的纵向队列和ADRC附属研究和临床试验中，代表不足的个人。 英国-ADRC的总体科学重点继续放在我们相互关联的主题上：过渡和 翻译。我们的特点良好的纵向队列和历史上强大的神经病理学计划 关注正常衰老、临床前疾病状态和早期认知转变一直是我们 成功地确定了从正常认知老化到 减损。我们调查人员的深度专业知识和合作性质也导致了 在将这一知识转化为新的靶点和新的治疗策略方面取得了实质性进展。这个 英国-ADRC提供了一个专注于这些综合主题和进展的基础设施和环境 通过高度互动和有效的组件开展广告研究、教育、推广和临床计划： 行政核心、临床核心、数据管理和统计核心、神经病理学核心、外展和 招聘核心、生物标记核心和研究教育部分。英国-ADRC将提供资源 从这些可用的核心支持ADRC神经成像补充的成功。

PROJECT SUMMARY/ABSTRACT – OVERALL (Adapted from Abstract of parent grant, UK-ADC) This is a proposal for a University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC) neuroimaging supplement. This purpose of the supplement is to provide neuroimaging data on the UK-ADRC’s deeply phenotyped clinical cohort to the NIH’s recently funded initiative, Standardized Centralized Alzheimer's and Related Dementias Neuroimaging (SCAN). In addition, a secondary purpose of this supplement is to identify neuroimaging correlates of two AD-mimics: limbic-predominant age-related TDP-43 encephalopathy (LATE) and primary age-related tauopathy (PART). The UK-ADRC is an experienced and collaborative ADRC originally funded in 1985. Our principal mission is to serve as the focal point for all AD-related activities at UK and this region of the United States, by providing an environment and core resources that catalyze innovative research, outreach, education, and clinical programs. Our signature resources include: 1) a cognitively normal group of ~500 subjects followed longitudinally, with all committed to brain autopsy upon death; 2) a strong program in clinical-neuropathological correlations and short postmortem interval autopsies; 3) an established program studying preclinical biomarkers of AD using neuroimaging and biofluids; 4) an integrated centralized database and innovative biostatistical expertise to characterize clinical and biological transitions; and 5) a successful and close partnership with the African-American community and increased participation of underrepresented individuals in our longitudinal cohort and ADRC-affiliated research studies and clinical trials. The overall scientific emphasis of the UK-ADRC continues to be on our interrelated themes: Transitions & Translation. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. The depth of expertise and collaborative nature of our investigators have also resulted in substantial progress on translation of that knowledge into new targets and novel therapeutic strategies. The UK-ADRC provides an infrastructure and environment that focuses on these integrated themes and advances AD research, education, outreach, and clinical programs through highly interactive and effective components: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core, Outreach and Recruitment Core, Biomarker Core, and Research Education Component. The UK-ADRC will make resources from these Cores available to support the success of this ADRC neuroimaging supplement.