Gene Ontology Consortium Supplemental

项目摘要 该提案的总体目标是开展广泛的初步工作， 导致GO和Reactome之间的互操作性和自动数据交换 资源我们并不期望通过一个补充完全实现互操作性，相反， 补编将支持查明所有需要解决的问题所需的工作， 并测试这些问题的解决方案。本补编建议的工作将使我们能够 制定一个详细的计划，这将是必要的，为未来的赠款申请。此外，本发明还提供了一种方法， 基于GO和Reactome已经共同进行的初步分析，我们还 我们期望从补贴中获得巨大的短期利益：它将使我们能够实现 几乎所有代谢途径（尽管不是信号传导途径）的互操作性。为 更广泛的基因组学社区，这项工作将导致一个更充分的互操作性的主要 基因组学资源和资源之间的协调模式，以确定和共享 明确的参考信息来源，以提高管理效率， 冗余我们的工作将利用BioPAX格式的数据，从而提高互操作性 GO与任何利用BioPAX的资源（这些资源整合在 PathwayCommons）。这种互操作性最终也将使策展更加有效， 在一个项目中策划的信息将大大加速其他项目的策划。

Project Summary The overall goal of the proposal is to perform extensive preliminary work that would ultimately lead to interoperability and to automatic data exchange between the GO and Reactome resources. We do not expect to fully achieve interoperability with a supplement, but, rather, the supplement will support the work needed to identify all the issues that need to be addressed, and to test solutions for these issues. The work proposed in this supplement will enable us to develop a detailed plan which would be necessary for future grant applications. In addition, based on an initial analysis that GO and Reactome have already performed together, we also expect substantial short-term benefits from the supplement: it will allow us to achieve interoperability for nearly all metabolic pathways (though not signaling pathways). For the broader genomics community, this work will result in a more fully interoperable set of major genomics resources and a model for coordination among resources to identify and share definitive sources of reference information for improved curation efficiency with minimal redundancy. Our work will utilize BioPAX-formatted data, thereby also enhancing interoperability of GO with any resource that utilizes BioPAX (these resources are integrated in PathwayCommons). This interoperability will also eventually make curation more efficient, as information curated in one project will greatly accelerate curation in other projects.