A tailored, health communication intervention for HPV vaccine hesitant families

为 HPV 疫苗犹豫家庭量身定制的健康沟通干预措施

• 批准号: 10166801
• 负责人: Jennifer C. Erves
• 金额: $ 13.63万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166801
• 关键词: Address; Adolescent; Advisory Committees; African American; Age; Anus; Anxiety; Applications Grants; Attitude; Award; Behavior; Behavior Therapy; Behavioral; Car Phone; Cervical; Childhood; Clinic; Clinic Visits; Clinical; Clinical Research; Clinical Trials; Complement; Computer software; Conduct Clinical Trials; Custom; Data; Disease; Dose; Education; Educational Intervention; Environment; Family; Feedback; Funding; Future; Goals; Health Personnel; Health education; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Human papilloma virus infection; Incidence; Individual; Interdisciplinary Study; Intervention; Intervention Studies; Interview; Knowledge; Leadership; Malignant Neoplasms; Malignant Vaginal Neoplasm; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of penis; Malignant neoplasm of vulva; Manuscripts; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Misinformation; Modeling; Modification; Morbidity - disease rate; Motivation; Oncology; Oropharyngeal; Outcomes Research; Parents; Patient Education; Patient-Focused Outcomes; Patients; Pediatrics; Perception; Physicians; Pilot Projects; Play; Population; Postdoctoral Fellow; Prevention Research; Process; Protocols documentation; Provider; Public Health; Publications; Randomized; Randomized Clinical Trials; Recommendation; Research; Research Methodology; Research Personnel; Resources; Role; Safety; Schedule; Secure; Sex Behavior; Site; Source; Statistical Data Interpretation; Structure; Surveys; Tennessee; Testing; Training; Training Activity; Treatment Efficacy; Trust; Underserved Population; Uninsured; Universities; Vaccines; Vagina; Visit; Vulva; Work; base; cancer prevention; career; career development; clinical care; clinical encounter; clinically significant; community engagement; control trial; disparity reduction; evidence base; experience; health belief; health communication; implementation science; improved; innovation; medical schools; mortality; motivational enhancement therapy; patient-clinician communication; penis; preference; prevent; professor; programs; public health priorities; public health relevance; public health research; recruit; retention rate; safety net; satisfaction; shared decision making; side effect; social norm; theories; therapy development; transmission process; treatment as usual; trial design; vaccine acceptance; vaccine access; vaccine hesitancy

Abstract The human papillomavirus (HPV) causes 90% of cervical cancers and is implicated in multiple other cancers. The HPV vaccine can prevent the vast majority of these cancers, but it is underused in adolescents, especially among those within vaccine hesitant (VH) parents. Dr. Erves, an Assistant Professor in Research at Meharry Medical College and Adjunct Assistant Professor at Vanderbilt University, is poised to become a leader in behavioral cancer prevention research. This Mentored Research Scientist Development Award (K01) will complement her in-depth training in public health research methods, statistical analysis, patient centered outcomes research, and community engagement obtained during her doctoral, post-doctoral, and early career experiences. It will provide the training she needs to further her current cancer prevention research program, characterizing preferences and perceived needs of African American adolescents and parents when deciding about HPV vaccination for cancer prevention. Dr. Erves short-term goals are to become proficient in behavioral intervention development, an expert in conducting clinical trials, and knowledgeable of implementation science by engaging in didactic, clinical research training activities; conducting a pilot, randomized clinical trial; submitting an R01 in Year 3 of this award; increasing manuscript publications; and advancing leadership through scientific presentations. Her mentors include highly-qualified experts in community engagement and clinical trials (Dr. Consuelo Wilkins), HPV vaccination and behavioral interventions (Dr. Pamela Hull), and vaccine hesitancy, clinical interventions, and implementation science (Dr. Amanda Dempsey). State-of-the-art facilities and vast resources at Meharry Medical College and Vanderbilt University provide the environment needed to promote her career development, and complete the proposed research successfully. The proposed research is to develop and pilot test a tailored, health communication intervention aimed to increase HPV vaccination among VH parents. The research will add knowledge on how tailored education provided before a doctor’s visit can play a role in improving HPV vaccination rates among underserved, VH parents. The study aims to develop a tailored, health communication intervention for HPV VH parents (AIM 1); conduct a pilot study of the intervention and study protocol on a small scale to demonstrate feasibility of a future full-scale randomized control trial (RCT) (AIM 2); and examine acceptability of the protocol and intervention among parents and providers (AIM 3). The proposed research is innovative because no evidence-based health communication interventions target HPV VH parents, and we will use stakeholder engagement throughout this study. The knowledge, experience, and pilot data provided by this award will prepare Dr. Erves to secure subsequent R01 funding to assess the intervention’s efficacy in a well-powered RCT and advance her multidisciplinary, research program on behavioral interventions to increase HPV vaccine rates. This award will allow her to establish an independent, long-term career focused more broadly on cancer prevention behaviors.

抽象的 90% 的宫颈癌是由人乳头瘤病毒 (HPV) 引起的，并且与多种其他癌症有关。 HPV 疫苗可以预防绝大多数此类癌症，但在青少年中并未得到充分利用，尤其是 那些对疫苗犹豫不决（VH）的父母。 Erves 博士，梅哈里研究助理教授 范德比尔特大学医学院和兼职助理教授，有望成为该领域的领导者 行为癌症预防研究。该指导研究科学家发展奖（K01）将 补充她在公共卫生研究方法、统计分析、以患者为中心方面的深入培训 在她的博士、博士后和早期职业生涯中获得的成果研究和社区参与 经验。它将提供她所需的培训，以进一步推进她目前的癌症预防研究计划， 描述非裔美国青少年和父母在做出决定时的偏好和感知需求 关于预防癌症的 HPV 疫苗接种。 Erves 博士的短期目标是精通行为学 干预开发、临床试验专家以及实施科学知识 参与教学、临床研究培训活动；进行试点随机临床试验； 在该奖项的第 3 年提交 R01；增加手稿出版物；并提升领导力 通过科学演示。她的导师包括社区参与方面的高素质专家 临床试验（Consuelo Wilkins 博士）、HPV 疫苗接种和行为干预（Pamela Hull 博士），以及 疫苗犹豫、临床干预和实施科学（阿曼达·登普西博士）。最先进的 梅哈里医学院和范德比尔特大学的设施和丰富的资源提供了环境 需要促进她的职业发展，并成功完成拟议的研究。拟议的 研究的目的是开发和试点测试一种量身定制的健康传播干预措施，旨在增加 HPV VH 父母之间接种疫苗。该研究将增加关于如何在入学前提供量身定制的教育的知识。 医生的就诊可以在提高服务不足的 VH 父母的 HPV 疫苗接种率方面发挥作用。研究 旨在为 HPV VH 父母制定量身定制的健康沟通干预措施（AIM 1）；进行试点 对干预措施和研究方案进行小规模研究，以证明未来全面实施的可行性 随机对照试验（RCT）（AIM 2）；并检查协议和干预措施的可接受性 父母和提供者（AIM 3）。拟议的研究具有创新性，因为没有基于证据的健康 沟通干预措施针对 HPV VH 父母，我们将在整个过程中利用利益相关者的参与 学习。该奖项提供的知识、经验和试点数据将使 Erves 博士做好准备，确保 随后的 R01 资金用于评估干预措施在强有力的随机对照试验中的功效，并推进她的研究 关于行为干预以提高 HPV 疫苗接种率的多学科研究计划。该奖项将 让她能够建立一个独立、长期的职业生涯，更广泛地关注癌症预防行为。