Effects of maternal thyroid function and thyroidal disruptor exposure on pregnancy and child developmental outcomes

项目总结/摘要 甲状腺激素是胎儿正常发育所必需的。碘是甲状腺必需的微量营养素 荷尔蒙分泌母亲甲状腺功能减退症，影响美国2-3%的孕妇，相关联 对妊娠结局和后代神经发育有不良影响。碘缺乏是导致 全球范围内的母亲甲状腺功能减退症的原因。虽然美国的一般人口被认为是碘 目前，美国孕妇有轻度碘缺乏症。暴露于甲状腺干扰 干扰碘利用的化学物质，如高氯酸盐和硫氰酸盐，在 孕妇及其子女等弱势群体。这些研究的目的是：（1）评估 孕妇高氯酸盐或硫氰酸盐暴露或孕期碘营养状况与孕妇 和新生儿甲状腺功能，2）进行一项初步研究，探讨母亲暴露于甲状腺激素 干扰化学物质和碘状态和不良妊娠结局，以及3）确定关联 母亲甲状腺功能减退与后代患语言障碍（一种神经发育障碍）风险之间的关系 与甲状腺功能紊乱有关这些发现将对以下方面产生重要影响 建议适当的碘营养和避免在怀孕期间暴露于EDC，可能 不良妊娠和发育结果的可改变风险因素。候选人是助理 波士顿大学医学院内分泌学、糖尿病和营养学教授 医学在波士顿，马萨诸塞州。她的短期目标是发展流行病学研究的技能， 关于生殖结果、环境流行病学以及孕产妇甲状腺健康与 通过教学课程和参加国家会议来评估后代的神经发育结果。她 长期目标是研究妊娠期母体EDC暴露对甲状腺功能的影响， 妊娠和后代结局，使用从拟议研究中获得的技能和发现， 基础工作多学科指导小组包括甲状腺学、碘营养和 利用，生殖和环境流行病学，和儿科神经发育。波士顿大学 医学院是开创性医学研究的公认领导者。作为波士顿大学的一部分， 作为美国第四大独立大学，医学中心联盟由 医学院、公共卫生学院、牙科学院和研究生医学科学部沿着 波士顿医疗中心，提供了一个丰富和多样化的环境，成功执行拟议的 研究以及候选人的发展成为一个独立资助的研究人员。

PROJECT SUMMARY/ABSTRACT Thyroid hormone is essential for normal fetal development. Iodine is an essential micronutrient for thyroid hormone production. Maternal hypothyroidism, affecting 2-3% of pregnant women in the U.S., is associated with adverse effects on pregnancy outcomes and offspring neurodevelopment. Iodine deficiency is the leading cause of maternal hypothyroidism worldwide. Although the general population of the U.S. is deemed iodine sufficient, U.S. pregnant women currently have mild iodine deficiency. Exposure to thyroidal disrupting chemicals that interfere with iodine utilization, such as perchlorate and thiocyanate, is of particular concern in vulnerable populations such as pregnant women and their offspring. The proposed studies aim to 1) assess correlations between maternal perchlorate or thiocyanate exposure or iodine status in pregnancy and maternal and newborn thyroid function, 2) conduct a pilot study of associations between maternal exposure to thyroidal disrupting chemicals and iodine status and adverse pregnancy outcomes, and 3) determine associations between maternal thyroid hypofunction and offspring risk of language disorder, a neurodevelopmental disorder with suggested associations with thyroid dysfunction. These findings will have important implications for recommendations for adequate iodine nutrition and for avoidance of exposure to EDC in pregnancy, potentially modifiable risk factors for adverse pregnancy and developmental outcomes. The candidate is an Assistant Professor of Medicine in the section of Endocrinology, Diabetes, and Nutrition at Boston University School of Medicine in Boston, Massachusetts. Her short-term goal is to develop skills in epidemiological studies focusing on reproductive outcomes, environmental epidemiology, and associations between maternal thyroid health and offspring neurodevelopmental outcomes through didactic courses and attendance at national meetings. Her long-term goal is to investigate the effects of maternal EDC exposure in pregnancy on thyroid function and pregnancy and offspring outcomes, using the skills and findings obtained from the proposed studies as the groundwork. The multidisciplinary mentoring team includes experts in thyroidology, iodine nutrition and utilization, reproductive and environmental epidemiology, and pediatric neurodevelopment. Boston University School of Medicine is a recognized leader in groundbreaking medical research. As a part of Boston University, the fourth-largest independent university in the United States, the medical center consortium consists of the Schools of Medicine, Public Health, Dentistry, and the Division of Graduate Medical Sciences along with Boston Medical Center, provides a rich and diverse environment for successful execution of the proposed studies as well as for the candidate's development into an independently funded researcher.