Effects of maternal thyroid function and thyroidal disruptor exposure on pregnancy and child developmental outcomes

项目摘要/摘要 甲状腺激素对胎儿的正常发育至关重要。碘是甲状腺必需的微量营养素 荷尔蒙的产生。在美国，影响2-3%孕妇的母亲甲状腺功能减退症与 对妊娠结局和后代神经发育有不良影响。缺碘是最主要的 世界范围内母亲甲状腺功能减退的原因。尽管美国的普通人口被认为是碘 足够了，美国孕妇目前有轻微的碘缺乏。暴露于甲状腺功能紊乱 干扰碘利用的化学物质，如高氯酸盐和硫氰酸盐，在 弱势群体，如孕妇及其后代。拟议的研究旨在1)评估 母体高氯酸盐或硫氰酸盐暴露或孕期碘状况与母体 和新生儿甲状腺功能，2)对母亲接触甲状腺激素之间的关系进行初步研究 扰乱化学物质和碘状况与不良妊娠结局，以及3)确定相关性 母亲甲状腺功能低下与后代患语言障碍的风险之间的关系 提示与甲状腺功能障碍有关。这些发现将对以下方面产生重要的影响 关于适当的碘营养和避免孕期接触EDC的建议，可能 不良妊娠和发育结果的可改变的危险因素。应聘者是助理 波士顿大学医学院内分泌学、糖尿病和营养学系医学教授 马萨诸塞州波士顿的医学。她的短期目标是培养专注于流行病学研究的技能 关于生殖结果、环境流行病学以及产妇甲状腺健康和 通过授课课程和参加国家会议的后代神经发育成果。她 长期目标是调查母亲孕期接触EDC对甲状腺功能和 妊娠和后代结局，使用从拟议研究中获得的技能和发现作为 做好基础工作。多学科指导团队包括甲状腺学、碘营养和 利用、生殖和环境流行病学以及儿科神经发育。波士顿大学 医学院是公认的开创性医学研究的领导者。作为波士顿大学的一部分， 医学中心联盟是美国第四大独立大学，由 医学院、公共卫生、牙科和医学研究生部 波士顿医疗中心，为成功执行拟议的 研究以及候选人发展成为独立资助的研究人员。

PROJECT SUMMARY/ABSTRACT Thyroid hormone is essential for normal fetal development. Iodine is an essential micronutrient for thyroid hormone production. Maternal hypothyroidism, affecting 2-3% of pregnant women in the U.S., is associated with adverse effects on pregnancy outcomes and offspring neurodevelopment. Iodine deficiency is the leading cause of maternal hypothyroidism worldwide. Although the general population of the U.S. is deemed iodine sufficient, U.S. pregnant women currently have mild iodine deficiency. Exposure to thyroidal disrupting chemicals that interfere with iodine utilization, such as perchlorate and thiocyanate, is of particular concern in vulnerable populations such as pregnant women and their offspring. The proposed studies aim to 1) assess correlations between maternal perchlorate or thiocyanate exposure or iodine status in pregnancy and maternal and newborn thyroid function, 2) conduct a pilot study of associations between maternal exposure to thyroidal disrupting chemicals and iodine status and adverse pregnancy outcomes, and 3) determine associations between maternal thyroid hypofunction and offspring risk of language disorder, a neurodevelopmental disorder with suggested associations with thyroid dysfunction. These findings will have important implications for recommendations for adequate iodine nutrition and for avoidance of exposure to EDC in pregnancy, potentially modifiable risk factors for adverse pregnancy and developmental outcomes. The candidate is an Assistant Professor of Medicine in the section of Endocrinology, Diabetes, and Nutrition at Boston University School of Medicine in Boston, Massachusetts. Her short-term goal is to develop skills in epidemiological studies focusing on reproductive outcomes, environmental epidemiology, and associations between maternal thyroid health and offspring neurodevelopmental outcomes through didactic courses and attendance at national meetings. Her long-term goal is to investigate the effects of maternal EDC exposure in pregnancy on thyroid function and pregnancy and offspring outcomes, using the skills and findings obtained from the proposed studies as the groundwork. The multidisciplinary mentoring team includes experts in thyroidology, iodine nutrition and utilization, reproductive and environmental epidemiology, and pediatric neurodevelopment. Boston University School of Medicine is a recognized leader in groundbreaking medical research. As a part of Boston University, the fourth-largest independent university in the United States, the medical center consortium consists of the Schools of Medicine, Public Health, Dentistry, and the Division of Graduate Medical Sciences along with Boston Medical Center, provides a rich and diverse environment for successful execution of the proposed studies as well as for the candidate's development into an independently funded researcher.