Effects of maternal thyroid function and thyroidal disruptor exposure on pregnancy and child developmental outcomes

母亲甲状腺功能和甲状腺干扰物暴露对妊娠和儿童发育结果的影响

• 批准号: 10631141
• 负责人: Sun Y Lee-Marquez
• 金额: $ 19.42万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631141
• 关键词: Adverse effects; Affect; Age; Applications Grants; Behavioral; Body Weight decreased; Boston; Case/Control Studies; Chemical Exposure; Chemicals; Child; Childhood; Clinical Research; Computerized Medical Record; Consumption; Data; Databases; Dentistry; Development; Diabetes Mellitus; Diagnosis; Endocrine Disruptors; Endocrinology; Environment; Environmental Epidemiology; Exposure to; Fetal Development; Food; Functional disorder; Funding; General Population; Goals; Health; Hospitals; Hypothyroidism; Immigrant; Impairment; Individual; Infant; Iodine; Knowledge; Language; Language Delays; Language Disorders; Learning Disabilities; Longitudinal Studies; Longitudinal cohort study; Low Birth Weight Infant; Massachusetts; Maternal Exposure; Medical; Medical Research; Medical center; Medicine; Memory; Mentors; Micronutrients; Mission; Mothers; National Institute of Environmental Health Sciences; Neonatal; Neurodevelopmental Disorder; Newborn Infant; Nursery Schools; Outcome; Patients; Perchlorates; Perinatal Epidemiology; Pilot Projects; Population; Positioning Attribute; Pregnancy; Pregnancy Outcome; Pregnant Women; Process; Production; Public Health; Reading; Recommendation; Research; Research Personnel; Research Project Grants; Retrospective cohort study; Risk; Risk Factors; School-Age Population; Science; Spontaneous abortion; Thiocyanates; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Training; United States; Universities; Vegetables; Vulnerable Populations; Woman; adverse pregnancy outcome; cigarette smoke; cohort; drinking water; early childhood; epidemiology study; fetal; fetal loss; food insecurity; iodine deficiency syndrome; low socioeconomic status; medical schools; meetings; modifiable risk; multidisciplinary; neurobehavioral; neurodevelopment; nutrition; offspring; patient population; premature; professor; prospective; psychosocial; racial minority; recruit; reproductive; reproductive epidemiology; reproductive outcome; safety net; skills; urinary

PROJECT SUMMARY/ABSTRACT Thyroid hormone is essential for normal fetal development. Iodine is an essential micronutrient for thyroid hormone production. Maternal hypothyroidism, affecting 2-3% of pregnant women in the U.S., is associated with adverse effects on pregnancy outcomes and offspring neurodevelopment. Iodine deficiency is the leading cause of maternal hypothyroidism worldwide. Although the general population of the U.S. is deemed iodine sufficient, U.S. pregnant women currently have mild iodine deficiency. Exposure to thyroidal disrupting chemicals that interfere with iodine utilization, such as perchlorate and thiocyanate, is of particular concern in vulnerable populations such as pregnant women and their offspring. The proposed studies aim to 1) assess correlations between maternal perchlorate or thiocyanate exposure or iodine status in pregnancy and maternal and newborn thyroid function, 2) conduct a pilot study of associations between maternal exposure to thyroidal disrupting chemicals and iodine status and adverse pregnancy outcomes, and 3) determine associations between maternal thyroid hypofunction and offspring risk of language disorder, a neurodevelopmental disorder with suggested associations with thyroid dysfunction. These findings will have important implications for recommendations for adequate iodine nutrition and for avoidance of exposure to EDC in pregnancy, potentially modifiable risk factors for adverse pregnancy and developmental outcomes. The candidate is an Assistant Professor of Medicine in the section of Endocrinology, Diabetes, and Nutrition at Boston University School of Medicine in Boston, Massachusetts. Her short-term goal is to develop skills in epidemiological studies focusing on reproductive outcomes, environmental epidemiology, and associations between maternal thyroid health and offspring neurodevelopmental outcomes through didactic courses and attendance at national meetings. Her long-term goal is to investigate the effects of maternal EDC exposure in pregnancy on thyroid function and pregnancy and offspring outcomes, using the skills and findings obtained from the proposed studies as the groundwork. The multidisciplinary mentoring team includes experts in thyroidology, iodine nutrition and utilization, reproductive and environmental epidemiology, and pediatric neurodevelopment. Boston University School of Medicine is a recognized leader in groundbreaking medical research. As a part of Boston University, the fourth-largest independent university in the United States, the medical center consortium consists of the Schools of Medicine, Public Health, Dentistry, and the Division of Graduate Medical Sciences along with Boston Medical Center, provides a rich and diverse environment for successful execution of the proposed studies as well as for the candidate's development into an independently funded researcher.

项目总结/文摘

项目成果

Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.

• DOI: 10.1038/s41574-021-00604-z
• 发表时间: 2022-03
• 期刊: NATURE REVIEWS ENDOCRINOLOGY
• 影响因子: 40.5
• 作者: Lee, Sun Y.;Pearce, Elizabeth N.
• 通讯作者: Pearce, Elizabeth N.

Changes in Urinary Iodine Levels Following Bariatric Surgery.

减肥手术后尿碘水平的变化。

• DOI: 10.1016/j.eprac.2023.06.008
• 发表时间: 2023
• 期刊: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
• 作者: Chiung-HuiPeng,Carol;Han,Cheng;Waisayanand,Nipawan;DeLeo,Simone;Srimatkandada,Pavani;Kommareddy,Swetha;Pearce,ElizabethN;He,Xuemei;Lee,SunY
• 通讯作者: Lee,SunY

Letter to the Editor: A Patient-Centered Survey-Based Assessment of Prenatal Management of Hypothyroidism for Women of Reproductive Age.

致编辑的信：以患者为中心、基于调查的育龄妇女甲状腺功能减退症产前管理评估。

• DOI: 10.1089/thy.2022.0032
• 发表时间: 2022
• 期刊: Thyroid : official journal of the American Thyroid Association
• 作者: Solomon,AlexandraL;Farwell,AlanP;Pearce,ElizabethN;Lee,SunY
• 通讯作者: Lee,SunY

Iodine Status in Pregnant Women of Puerto Rico.

• DOI: 10.1016/j.eprac.2020.10.002
• 发表时间: 2021-03
• 期刊: ENDOCRINE PRACTICE
• 影响因子: 4.2
• 作者: Rodriguez-Diaz, Eduardo;Rivera-Ortiz, Jinetsy, I;Lee, Sun Y.;Gonzalez-Rodriguez, Loida A.;He, Xuemei;Pearce, Elizabeth N.
• 通讯作者: Pearce, Elizabeth N.

Investigating hypothyroidism.

研究甲状腺功能减退症。

• DOI: 10.1136/bmj.n993
• 发表时间: 2021
• 期刊: BMJ (Clinical research ed.)
• 作者: Siskind,SamanthaM;Lee,SunY;Pearce,ElizabethN
• 通讯作者: Pearce,ElizabethN