权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Novel gas chromatography for rapid, in situ workplace hazardous VOC/VIC analysis

用于快速现场工作场所危险 VOC/VIC 分析的新型气相色谱法

基本信息

批准号：
10171393
负责人：
Xudong Fan
金额：
$ 25.26万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10171393
关键词：
Novel gas chromatography rapid situ

项目摘要

Workers are exposed every day to various hazardous volatile organic/inorganic compounds (VOCs/VICs) that can affect their safety and long-term health. Gas chromatography (GC) has long been considered to be the most promising and most commonly used method to analyze various VOCs/VICs. However, bench-top GC instruments are bulky and are usually placed in centralized labs, and thus cannot be field-deployable. Meanwhile, existing portable GC and micro-GC (µGC) on the market have limited peak capacity, handle only a small, well-defined set of chemicals, and often fail when encountering complex VOCs/VICs that can be seen in a workplace. Consequently, there is an urgent need for a device capable of rapidly and sensitively analyzing a large number of VOCs/VICs while maintaining portability and being cost-effective. The goal of the proposed project is to develop a low-cost high-performance portable automated µGC device based on a novel 3- dimensional (3-D) µGC design and highly sensitive high-speed vapor sensors. It can perform rapid (<20 min), sensitive (ppt), and in-situ analysis of hundreds of workplace VOCs/VICs for worker exposure assessment. In the proposed project, a complete fully automated 3-D µGC device will be developed and built on a chip, which will include pre-concentrators, thermal injector, micro-separation columns, flow controls, and vapor detectors. Over 100 VOCs/VICs representing various workplace exposures will be used as model systems to characterize and evaluate the performance of the device. A corresponding VOC/VIC reference library will be created for those compounds. Finally, the device, in conjunction with the pre-built VOC/VIC library, will be used to quantitatively analyze VOCs/VICs in an experimental workplace environment, as well as in real-world indoor workplace and outdoor industrial or post-industrial environments. The performance will be benchmarked against conventional industrial hygiene methods. In this 3.5-year project, we will accomplish the following five specific aims: Aim 1: Design, micro-fabricate, characterize, and optimize the components for 3-D µGC devices. Aim 2: Assemble the 3-D µGC device and develop the operation/analysis algorithm. Aim 3: Integrate an automated VIC detection module. Aim 4: Characterize and optimize the 3-D µGC device, and create a VOC/VIC reference library. Aim 5: Field-test the 3-D µGC device and benchmark against conventional industrial hygiene methods. The proposed project addresses one of the NIOSH cross-sectors - “EXPOSURE ASSESSMENT” – by developing a new analytical device to better evaluate worker exposures to hazardous VOCs/VICs. The intermediate outcomes will include journal articles, citations in the literature, inventions and patents, and adoption of technologies developed in the project. The end outcomes will be a reduction in workplace hazardous exposures and related illnesses.

工人每天都暴露在各种有害的挥发性有机/无机化合物（VOC/VIC）中。这可能会影响他们的安全和长期健康。气相色谱法（GC）长期以来被认为是最有前途和最常用的方法来分析各种VOCs/VIC。然而，台式GC 仪器体积庞大，并且通常放置在中央实验室中，因此不能现场部署。同时，市场上现有的便携式GC和微型GC（µGC）的峰值容量有限，只能处理小，定义明确的化学品，并经常失败时，遇到复杂的挥发性有机化合物/挥发性有机化合物，可以看到，工作场所因此，迫切需要一种能够快速且灵敏地分析样品的装置。大量的VOC/VIC，同时保持便携性和成本效益。建议的目标项目是开发一种低成本高性能便携式自动化µGC设备，该设备基于一种新型的3- 三维（3-D）µGC设计和高灵敏度高速蒸汽传感器。它可以快速（<20分钟），对数百种工作场所VOC/VIC进行敏感（PPT）和现场分析，以进行工人暴露评估。在在拟议的项目中，将开发一个完整的全自动3-D µGC设备，并在芯片上构建，将包括预浓缩器、热注射器、微分离柱、流量控制器和蒸汽检测器。超过100种代表各种工作场所暴露的VOC/VIC将被用作模型系统，表征和评价器械的性能。将建立一个相应的VOC/维克中心参考资料库，为这些化合物而创建。最后，该设备将与预建的VOC/维克库一起使用在实验工作环境以及真实室内环境中定量分析VOC/VIC 工作场所和户外工业或后工业环境。业绩将被基准化与传统的工业卫生方法相比。在这个3.5年的项目中，我们将完成以下五项工作具体目标：目标1：设计、微制造、表征和优化3-D µGC器件的组件。目标2：组装3-D µGC装置并开发操作/分析算法。目标3：集成自动化维克检测模块。目标4：表征和优化3-D µGC装置，并创建VOC/维克参考库。目标5：现场测试3-D µGC设备，并与传统的工业卫生方法进行基准测试。拟议项目涉及NIOSH跨部门之一-“暴露评估”，开发一种新的分析设备，以更好地评估工人接触有害VOC/VIC的情况。的中期成果将包括期刊文章、文献引用、发明和专利，采用项目中开发的技术。最终结果将是减少工作场所危险暴露和相关疾病。