Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)

精准医学高级代谢成像中心 (CAMIPM)

• 批准号: 10172047
• 负责人: Ravinder Reddy
• 金额: $ 162.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10172047
• 关键词: Advanced Development; Advisory Committees; Alzheimer' s Disease; Area; Arthritis; Basic Science; Biological; Biological Markers; Biomedical Engineering; Biomedical Research; Brain; Cardiovascular Diseases; Cardiovascular system; Chemicals; Clinical; Clinical Investigator; Clinical Management; Clinical Research; Collaborations; Country; Data; Data Set; Development; Diagnosis; Disease; Early Diagnosis; Educational workshop; Engineering; Ensure; Environment; Epilepsy; Extramural Activities; Faculty; Fostering; Funding; Genetic; Geography; Goals; Health; Healthcare; Heart; Heart Diseases; Housing; Human; Image; Imaging Device; Imaging technology; Individual; Institution; Intervention; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Measures; Medical Imaging; Medicine; Metabolic; Metabolism; Molecular; Monitor; Muscle; Musculoskeletal; Musculoskeletal Diseases; Oncology; Oxygen Consumption; Patient Care; Peer Review; Pennsylvania; Physiologic pulse; Physiological; Physiology; Placenta; Population; Postdoctoral Fellow; Property; Protocols documentation; Publications; Records; Reproducibility; Research; Research Institute; Research Personnel; Research Training; Resources; Sampling; Scientist; Services; Skeletal Muscle Neoplasm; Spectrum Analysis; Stroke; Structure; Students; Technology; Therapeutic; Therapeutic Intervention; Tissues; Training; Training Programs; Translating; Translations; Universities; Validation; Visit; base; bench to bedside; bioimaging; biomedical resource; clinical care; data analysis pipeline; design; diffuse optical spectroscopy and imaging; experience; imaging biomarker; innovation; instrument; metabolic imaging; neuropsychiatry; new technology; next generation; novel; novel strategies; novel therapeutics; optical imaging; patient stratification; personalized approach; personalized diagnostics; personalized medicine; personalized strategies; precision medicine; program dissemination; targeted biomarker; technological innovation; technology development; technology research and development; technology validation; tool; training opportunity; tumor; visiting scholar; web site

ABSTRACT The “Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)” is a National Center for Biomedical Imaging and Bioengineering (NCBIB) that will develop and translate cutting edge noninvasive metabolic imaging biomarkers for use in biomedical research. Technology development is focused in four major application areas: Oncology, Cardiovascular, Neuropsychiatric, and Musculoskeletal. Driven by collaborators across the country and in partnership with Penn’s clinical research institutes in these areas, a range of novel technologies will be developed, optimized, and implemented with the goal of providing mechanistic understanding of disease states based on fundamental biological properties that can also serve as treatment targets and biomarkers for monitoring therapeutic interventions. The proposed technological development will span from bench to bedside and will include a significant clinical research component. Four synergistic technological research and development (TR&D) projects will focus on 1) Chemical Exchange Weighted Molecular MRI for metabolic mapping in brain, heart, skeletal muscle, and tumors, 2) MRI Mapping of Oxygen Consumption in brain, muscle, and placenta 3) Down Field Spectroscopy of brain, heart, skeletal muscle, and tumors, and 4) Diffuse Optical imaging in tumors, brain, and muscle. Each of these TR&D projects will innovate and validate novel strategies for measuring tissue metabolism and translate these technologies to clinical populations through its collaborative projects, and dissemination through sharing of instrument design, MRI pulse sequences, data processing pipelines, and sample data as well as serving a multitude of funded service projects. The CAMIPM also proposes an extensive training and dissemination program in biomedical imaging through seminars, workshops, peer reviewed publications, targeted courses, hands-on training and a dedicated website and will train collaborators, service project investigators, students, postdoctoral fellows, and visiting scholars in the resource developed technologies. Core investigators have an outstanding track record of imaging technology research, technology dissemination, and of training the next generation of scientists in biomedical imaging technologies. An administrative component consisting of both internal and external advisory committees will oversee the fiscal matters, day-to-day activities as well as coordinate the TR&Ds, collaborations and service components. This project leverages an outstanding biomedical research environment with extensive resources for biomedical imaging research, strong institutional support, a compact campus housing nationally leading research and health care enterprises in very close proximity to basic science and engineering departments, closely integrated clinical-research institutes, and outstanding faculty and trainees. With its stellar faculty and unique biomedical focus, the CAMIPM is committed to interdisciplinary pursuit of basic and clinical research through technology development driven by its collaborators and through service to users geographically distributed across the country and thus has all the attributes required for a national NCBIB.

抽象的 “精密医学中高级代谢成像中心（CAMIPM）”是国家的国家中心 生物医学成像和生物工程（NCBIB）将发展和翻译最前沿无创 代谢成像生物标志物用于生物医学研究。技术开发集中在四个主要 应用领域：肿瘤学，心血管，神经精神病学和肌肉骨骼。由合作者驱动 在全国各地，并与宾夕法尼亚州的临床研究机构合作，这是一系列新颖的 将开发，优化和实施技术，以提供机械 理解基于基本生物学特性的疾病状态，也可以作为治疗 监测治疗干预措施的靶标和生物标志物。拟议的技术发展将 从长凳到床边的跨度，将包括重要的临床研究组成部分。 四个协同技术研发（TR＆D）项目将重点关注1）化学交换 加权分子MRI用于大脑，心脏，骨骼肌肉和肿瘤中的代谢映射，2）MRI映射 大脑，肌肉和plapeta中的氧气消耗3）大脑，心脏，骨骼肌肉的田间光谱检查， 和肿瘤，以及4）在肿瘤，大脑和肌肉中扩散光学成像。这些TR＆D项目中的每一个都将 创新和验证了测量组织代谢的新型策略，并将这些技术转化为 通过其协作项目的临床人群，并通过共享仪器设计传播， MRI脉冲序列，数据处理管道和样本数据以及提供多种资助的 服务项目。 Camipm还提出了一项广泛的生物医学培训和传播计划 通过半手，讲习班，同行评审的出版物，有针对性的课程，动手培训和 专门的网站，将培训合作者，服务项目调查员，学生，博士后研究员和 在资源开发的技术中访问学者。核心调查人员有一个出色的记录 成像技术研究，技术传播和培训下一代科学家 生物医学成像技术。由内部和外部咨询组成的管理组件 委员会将监督财政事务，日常活动以及协调TR＆D，合作 和服务组件。该项目利用广泛的生物医学研究环境 生物医学成像研究，强大的机构支持，紧凑型校园住房的资源 领先的研究和卫生保健企业非常靠近基础科学和工程 部门，紧密整合的临床研究机构以及杰出的教职员工。凭借其出色的 教师和独特的生物医学重点，Camipm致力于跨学科追求基本和临床 通过其合作者驱动的技术开发以及通过地理用户服务的技术开发研究 分布在全国各地，因此具有国家NCBIB所需的所有属性。