Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)

精准医学高级代谢成像中心 (CAMIPM)

• 批准号: 10669223
• 负责人: Ravinder Reddy
• 金额: $ 119.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669223
• 关键词: Advanced Development; Advisory Committees; Alzheimer' s Disease; Area; Arthritis; Basic Science; Biological; Biological Markers; Biomedical Engineering; Biomedical Research; Brain; Cardiovascular Diseases; Cardiovascular system; Chemicals; Clinical; Clinical Investigator; Clinical Management; Clinical Research; Collaborations; Country; Data; Data Set; Dedications; Development; Diagnosis; Disease; Early Diagnosis; Educational workshop; Engineering; Ensure; Environment; Epilepsy; Extramural Activities; Faculty; Fostering; Funding; Genetic; Geography; Goals; Health; Healthcare; Heart; Heart Diseases; Housing; Human; Image; Imaging Device; Imaging technology; Individual; Institution; Intervention; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measurement; Measures; Medical Imaging; Medicine; Metabolic; Metabolism; Molecular; Monitor; Muscle; Musculoskeletal; Musculoskeletal Diseases; Oncology; Oxygen Consumption; Patient Care; Peer Review; Pennsylvania; Physiologic pulse; Physiological; Physiology; Placenta; Population; Postdoctoral Fellow; Property; Protocols documentation; Publications; Records; Reproducibility; Research; Research Institute; Research Personnel; Resources; Sampling; Scientist; Services; Skeletal Muscle; Spectrum Analysis; Stroke; Students; Technology; Therapeutic; Therapeutic Intervention; Tissues; Training; Training Programs; Translating; Translations; Universities; Validation; Visit; bench to bedside; biomedical imaging; biomedical resource; clinical care; data analysis pipeline; design; diffuse optical spectroscopy and imaging; experience; imaging biomarker; innovation; instrument; metabolic imaging; neuropsychiatry; new technology; next generation; novel; novel strategies; novel therapeutics; optical imaging; patient stratification; personalized approach; personalized diagnostics; personalized medicine; personalized strategies; precision medicine; program dissemination; technological innovation; technology development; technology research and development; technology validation; tool; training opportunity; tumor; visiting scholar; web site

ABSTRACT The “Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)” is a National Center for Biomedical Imaging and Bioengineering (NCBIB) that will develop and translate cutting edge noninvasive metabolic imaging biomarkers for use in biomedical research. Technology development is focused in four major application areas: Oncology, Cardiovascular, Neuropsychiatric, and Musculoskeletal. Driven by collaborators across the country and in partnership with Penn’s clinical research institutes in these areas, a range of novel technologies will be developed, optimized, and implemented with the goal of providing mechanistic understanding of disease states based on fundamental biological properties that can also serve as treatment targets and biomarkers for monitoring therapeutic interventions. The proposed technological development will span from bench to bedside and will include a significant clinical research component. Four synergistic technological research and development (TR&D) projects will focus on 1) Chemical Exchange Weighted Molecular MRI for metabolic mapping in brain, heart, skeletal muscle, and tumors, 2) MRI Mapping of Oxygen Consumption in brain, muscle, and placenta 3) Down Field Spectroscopy of brain, heart, skeletal muscle, and tumors, and 4) Diffuse Optical imaging in tumors, brain, and muscle. Each of these TR&D projects will innovate and validate novel strategies for measuring tissue metabolism and translate these technologies to clinical populations through its collaborative projects, and dissemination through sharing of instrument design, MRI pulse sequences, data processing pipelines, and sample data as well as serving a multitude of funded service projects. The CAMIPM also proposes an extensive training and dissemination program in biomedical imaging through seminars, workshops, peer reviewed publications, targeted courses, hands-on training and a dedicated website and will train collaborators, service project investigators, students, postdoctoral fellows, and visiting scholars in the resource developed technologies. Core investigators have an outstanding track record of imaging technology research, technology dissemination, and of training the next generation of scientists in biomedical imaging technologies. An administrative component consisting of both internal and external advisory committees will oversee the fiscal matters, day-to-day activities as well as coordinate the TR&Ds, collaborations and service components. This project leverages an outstanding biomedical research environment with extensive resources for biomedical imaging research, strong institutional support, a compact campus housing nationally leading research and health care enterprises in very close proximity to basic science and engineering departments, closely integrated clinical-research institutes, and outstanding faculty and trainees. With its stellar faculty and unique biomedical focus, the CAMIPM is committed to interdisciplinary pursuit of basic and clinical research through technology development driven by its collaborators and through service to users geographically distributed across the country and thus has all the attributes required for a national NCBIB.

摘要 “精准医学高级代谢成像中心（CAMIPM）”是一个国家中心， 生物医学成像和生物工程（NCBIB），将开发和翻译尖端的非侵入性 用于生物医学研究的代谢成像生物标志物。技术发展主要集中在四个方面 应用领域：肿瘤学、心血管、神经精神和肌肉骨骼。由合作者驱动 在全国范围内，并与宾夕法尼亚大学在这些领域的临床研究机构合作， 将开发、优化和实施技术，目标是提供 基于基本生物学特性的疾病状态的理解，也可以作为治疗 用于监测治疗干预的靶标和生物标志物。拟议的技术发展将 从实验台到床边，将包括一个重要的临床研究组成部分。 四个协同技术研究和发展项目将集中在1）化学品交换 加权分子MRI用于脑、心脏、骨骼肌和肿瘤的代谢绘图，2）MRI绘图 脑、肌肉和胎盘中的耗氧量3）脑、心脏、骨骼肌的下场光谱， 以及4）肿瘤、脑和肌肉中的漫射光学成像。每个研发项目都将 创新和验证测量组织代谢的新策略，并将这些技术转化为 通过其合作项目的临床人群，并通过共享仪器设计的传播， MRI脉冲序列、数据处理管道和样本数据，以及为众多受资助的 服务项目。CAMIPM还提出了一个广泛的生物医学培训和传播计划， 通过研讨会、讲习班、同行评审的出版物、有针对性的课程、实践培训和 专门的网站，并将培训合作者，服务项目调查员，学生，博士后研究员， 访问学者在资源开发技术。核心调查人员在以下方面有着出色的记录： 成像技术研究，技术传播，以及培养下一代科学家， 生物医学成像技术。行政部门，包括内部和外部咨询部门 委员会将监督财务事项、日常活动，并协调TR& D、合作 和服务组件。该项目利用了出色的生物医学研究环境， 生物医学成像研究的资源，强大的机构支持，全国紧凑的校园住房 领先的研究和医疗保健企业非常接近基础科学和工程 系，紧密结合的临床研究机构，和优秀的教师和学员。凭借其恒星 教师和独特的生物医学重点，CAMIPM致力于跨学科的追求基础和临床 通过由合作者推动的技术开发和通过向地理上的用户提供服务进行研究 分布在全国各地，因此具有国家NCBIB所需的所有属性。

项目成果

Genetics of glutamate and its receptors in autism spectrum disorder.

• DOI: 10.1038/s41380-022-01506-w
• 发表时间: 2022-05
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Nisar, Sabah;Bhat, Ajaz A.;Masoodi, Tariq;Hashem, Sheema;Akhtar, Sabah;Ali, Tayyiba Akbar;Amjad, Sara;Chawla, Sanjeev;Bagga, Puneet;Frenneaux, Michael P.;Reddy, Ravinder;Fakhro, Khalid;Haris, Mohammad
• 通讯作者: Haris, Mohammad

Feasibility of transient nuclear Overhauser effect imaging in brain at 7 T.

7 T 脑内瞬态核欧沃豪塞效应成像的可行性。

• DOI: 10.1002/mrm.29519
• 发表时间: 2023
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Kumar,Dushyant;Benyard,Blake;Soni,NarayanDatt;Swain,Anshuman;Wilson,Neil;Reddy,Ravinder
• 通讯作者: Reddy,Ravinder

Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD.

• DOI: 10.1016/j.neuroimage.2022.118952
• 发表时间: 2022-04-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Lee, Hyunyeol;Wehrli, Felix W.
• 通讯作者: Wehrli, Felix W.

A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI.

氧气输送的流动扩散模型，用于通过单一气体校准的功能磁共振成像定量绘制脑氧代谢率 (CMRO2)。

• DOI: 10.1177/0271678x221077332
• 发表时间: 2022
• 期刊: official journal of the International Society of Cerebral Blood Flow and Metabolism
• 作者: Chiarelli AM