Behavioral Core

项目摘要-行为核心 中心实验室专注于识别调节或调节细胞信号通路 可卡因的增强作用。因此，行为核心将成为该中心的一个组成部分 这将使中心的研究人员能够评估操纵这些细胞信号通路对 可卡因的增强作用。尽管人们普遍认为自我给药化验是最好的 评估滥用药物强化性能的方法，约翰霍普金斯大学没有设施 需要进行这些关键的化验。因此，拟议中心的一个基本目标是建立和 运行行为核心，提供执行这些关键行为所需的培训和设施 学习。

Project Summary –Behavioral Core Center laboratories are focused on identifying cell signaling pathways that mediate or regulate cocaine's reinforcing properties. Accordingly, the Behavioral Core will be an integral component of the Center that will enable Center investigators to evaluate the impact of manipulating these cell signaling pathways on cocaine's reinforcing properties. Although it is generally agreed that self-administration assays are the best approach to evaluating the reinforcing properties of drugs of abuse, Johns Hopkins does not have facilities needed to conduct these key assays. Accordingly, an essential goal of the proposed Center is to establish and run a Behavioral Core that will provide the training and facilities needed to conduct these critical behavioral studies.