Behavioral Core

行为核心

• 批准号: 10404514
• 负责人: Mikhail V Pletnikov
• 金额: $ 19.62万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404514
• 关键词: Behavioral; Behavioral Assay; Behavioral Paradigm; Biological Assay; Catheters; Cocaine; Cocaine Dependence; Drug abuse; Equipment; Future; Goals; Human Resources; Investigation; Laboratories; Link; Maintenance; Mediating; Molecular; Motor Activity; Mus; National Institute of Drug Abuse; Pathway interactions; Play; Property; Research; Research Personnel; Role; Running; Self Administration; Signal Pathway; Signal Transduction; Testing; Training; base; behavioral study; conditioned fear; conditioned place preference; design; drug of abuse; experimental study; genetic manipulation; insight; morris water maze; new therapeutic target; novel strategies; programs; recruit; translational potential

Project Summary –Behavioral Core Center laboratories are focused on identifying cell signaling pathways that mediate or regulate cocaine's reinforcing properties. Accordingly, the Behavioral Core will be an integral component of the Center that will enable Center investigators to evaluate the impact of manipulating these cell signaling pathways on cocaine's reinforcing properties. Although it is generally agreed that self-administration assays are the best approach to evaluating the reinforcing properties of drugs of abuse, Johns Hopkins does not have facilities needed to conduct these key assays. Accordingly, an essential goal of the proposed Center is to establish and run a Behavioral Core that will provide the training and facilities needed to conduct these critical behavioral studies.

项目总结-行为核心