Altered Motor Function & Force Feedback After Spinal Cord Injury

运动功能改变

• 批准号: 10171923
• 负责人: DENA R. HOWLAND
• 金额: $ 57.23万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10171923
• 关键词: Acute; Animals; Area; Behavior; Bilateral; Chest; Data; Data Collection; Databases; Decerebrate State; Decerebration procedure; Development; Distal; Dorsal; Extensor; Feedback; Felis catus; Gait; Goals; Golgi Targeting; Golgi Tendon Organs; Human; Immunohistochemistry; Injury; Joints; Laboratories; Lateral; Leg; Lesion; Limb structure; Link; Locomotion; Maps; Mediating; Methods; Modeling; Motor; Movement; Muscle; Normal Statistical Distribution; Pathway interactions; Pattern; Performance; Phase; Preparation; Procedures; Production; Publishing; Recovery; Reflex action; Rehabilitation therapy; Research; Silver; Spinal; Spinal Cord; Spinal cord injury; Stains; System; Testing; Time; Walking; Weight; Work; base; design; experimental study; force feedback; gait examination; gait rehabilitation; injured; innovation; insight; kinematics; locomotor tasks; motor control; motor disorder; nervous system disorder; novel; preservation; programs; receptor; relating to nervous system; response; spinal tract; treadmill; white matter

Extensor muscles of the hind limbs are actively involved in weight support and walking activities. These muscles are extensively linked by inhibitory, force dependent pathways which contribute to the successful execution of a range of functional behaviors, including locomotion. These reflex pathways are thought to arise from Golgi tendon organs and are believed to regulate limb stiffness and promote inter-joint coordination during movements. Weightings of these linkages vary across control, decerebrate animals when quiescent, but obey a proximal to distal gradient during stepping on a treadmill. This finding indicates the strength and distribution of these reflex pathways are subject to modulation in a task-dependent manner. Our preliminary data in animals suggest that spinal cord hemisection alters the normal distribution and a dominant distal-to-proximal inhibitory gradient emerges. Animals with this lesion do not exhibit clasp-knife inhibition, a phenomenon mediated by receptors other than Golgi tendon organs and that results from bilateral injury to the dorsal half of the spinal cord. Changes in the strength and distribution of force feedback that we have observed is correlated with diminished limb stiffness and poor weight acceptance during locomotor tasks – both of which are problems seen in humans with spinal cord injuries (SCIs). These findings provide new insight into potential mechanisms contributing to disruption of motor function following injury. Our guiding hypothesis is: SCI- induced force-feedback dysregulation results in strong inhibition directed toward proximal muscles and contributes to inadequate limb stiffness during weight support phases of movement. The current application has evolved from collaborative work across two established laboratories, bringing together expertise in SCI, plasticity, force feedback and motor control. The proposed studies are designed to understand and map changes in force feedback control following SCI, characterize associated changes in gait subphases where inhibitory force feedback is thought to be most active across diverse locomotor tasks, and determine which white matter tracts may modulate spinal circuitry responsible for force feedback. Data generated in the proposed projects will be compared with an existing laboratory database containing force feedback findings from control decerebrate preparations. Overall, findings from these studies will explicate the impact of disrupting this intralimb control system on performance, provide critical mechanistic insight likely to be essential for design of the most effective rehabilitation programs for those with SCIs and other neurological disorders, and lay groundwork for development of a new method for testing force feedback in humans

后肢伸肌积极参与重量支撑和行走活动。

项目成果

A three dimensional multiplane kinematic model for bilateral hind limb gait analysis in cats.

• DOI: 10.1371/journal.pone.0197837
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Brown NP;Bertocci GE;Cheffer KA;Howland DR
• 通讯作者: Howland DR

Parametric control of limb mechanics is accomplished in the spinal cord by parallel-distributed processing: A commentary on the review "Laws of nature that define biological action and perception" by Mark L. Latash.

肢体力学的参数控制是通过并行分布式处理在脊髓中完成的：对 Mark L. Latash 的评论“定义生物行为和感知的自然法则”的评论。

• DOI: 10.1016/j.plrev.2021.03.003
• 发表时间: 2021
• 期刊: Physics of life reviews
• 影响因子: 11.7
• 作者: Nichols,TRichard

Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.

• DOI: 10.1002/jnr.24630
• 发表时间: 2020-08
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Niazi, Irrum F.;Lyle, Mark A.;Rising, Aaron;Howland, Dena R.;Nichols, T. Richard
• 通讯作者: Nichols, T. Richard

Non-uniform upregulation of the autogenic stretch reflex among hindlimb extensors following lateral spinal lesion in the cat.

• DOI: 10.1007/s00221-020-06016-1
• 发表时间: 2021-09
• 期刊: EXPERIMENTAL BRAIN RESEARCH
• 影响因子: 2
• 作者: Kajtaz, E.;Montgomery, L. R.;McMurtry, S.;Howland, D. R.;Nichols, T. Richard
• 通讯作者: Nichols, T. Richard