Force Feedback Redistribution & Eccentric-Focused Rehab post-SCI
力反馈重新分配
基本信息
- 批准号:10597524
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-01 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnimal ModelAnimalsBehaviorBilateralCharacteristicsChestChronicCicatrixDataData CollectionDatabasesDecerebrate StateDevelopmentDiseaseDistalDorsalExperimental DesignsExtensorFeedbackFelis catusGaitGoalsGolgi Tendon OrgansHealthHistologyHumanInjuryJointsKnowledgeLaboratoriesLateralLegLesionLimb structureLinkLocomotionLocomotor trainingMapsMediatingMissionModelingMotorMotor SkillsMovementMuscleNormal Statistical DistributionPathway interactionsPerformancePhasePhysical RehabilitationPreparationProceduresProductionProductivityQuality of lifeRampRecoveryReflex actionRehabilitation therapyResearchResearch ProposalsSpecificitySpinalSpinal CordSpinal Cord LesionsSpinal cord injuryStainsSystemTestingThoracic spinal cord structureTimeTissuesTrainingVeteransWalkingWeightWorkbasecare systemsdesignevidence baseexperimental studyforce feedbackgait examinationgait rehabilitationimprovedinjuredinnovationinsightkinematicslocomotor tasksmotor controlmotor disordermotor recoverymotor rehabilitationnervous system disordernovelreceptorrehabilitation strategyrelating to nervous systemresponsetranslational modeltreadmill
项目摘要
Extensor muscles of the leg are actively involved in weight support and walking activities. These muscles are
extensively linked by inhibitory, bidirectional, force dependent pathways that contribute to the successful
execution of a range of functional behaviors, including locomotion. These reflex pathways are thought to arise
from Golgi tendon organs and are believed to regulate limb stiffness and promote inter-joint coordination during
movements. The relative magnitudes of these linkages in the two directions between any two muscles vary
across control decerebrate animals when quiescent, but obey a predominantly proximal to distal gradient
during stepping on a treadmill. This finding indicates that the strength and distribution of these reflex pathways
are subject to modulation in a task-dependent manner. Our preliminary data suggest that thoracic spinal cord
lateral hemisection immediately and persistently alters the normal distribution and a dominant distal-to-
proximal inhibitory gradient emerges. Animals with this lesion do not exhibit clasp-knife inhibition, a
phenomenon known to be mediated by receptors other than Golgi tendon organs and that results from bilateral
injury to the dorsal half of the spinal cord. The change in the strength and distribution of force feedback that
we have observed is correlated with diminished limb stiffness and poor weight acceptance during locomotor
tasks – both of which are challenging problems seen in humans with spinal cord injuries. These findings
provide new insight into potential mechanisms contributing to disruption of motor function following injury and
identify a new, potential rehabilitation strategy. Our guiding hypothesis is that SCI-induced force-feedback
dysregulation results in strong inhibition directed toward proximal muscles, contributes to inadequate
limb stiffness during weight support phases of movement, and can be reversed using eccentric-
focused training. The current application has evolved from collaborative work, using a large animal model,
across two established laboratories, bringing together expertise in spinal cord injury, plasticity, force feedback
and motor control. The proposed studies are divided into two sets of experiments. The first set will carefully
characterize the impact of a low thoracic hemisection on gait kinematics during subphases where inhibitory
force feedback is thought to be most active (Aim 1a). These phases typically are associated with coordinated
eccentric activity and/or weight acceptance/support. Pre- and post-SCI data, across time, will be compared. In
the same animals, a comprehensive picture of force-feedback organization following SCI will be developed
during terminal decerebrate studies at two chronic time points (Aim 1b). Both standing and walking
preparations, in combination with mechanographic approaches, will be used to test task-specificity of
heterogenic force feedback responses in specific muscle combinations. In the second set of experiments, the
basic experimental design is the same except that eccentric-focused training will be introduced at 2 wks post-
SCI. This allows animals used in Aims 1a and 1b to serve as the controls for Aims 2a and 2b. Eccentric
training will use different ‘downslope’ gait tasks to more strongly activate force feedback circuitry. Gait
kinematics will be carefully assessed during select subphases to test for training effects during different flat and
downslope tasks (Aim 2a) and decerebrate, mechanographic studies used to characterize training effects on
force dependent organization at the level of specific muscle combinations. Histology will be completed in all
animals to verify lesion characteristics. Data generated in the proposed work will be compared with an existing
laboratory database containing force feedback findings from control decerebrate preparations, to reduce the
number of animals used. Collectively, these studies will provide important information for evidence-based
rehabilitation of motor skills by understanding the gait-associated impact of disrupting force feedback (Aim 1a),
the extent of the disruption of this intralimb control system following SCI (Aim 1b), and the potential to alter this
disruption at the voluntary gait (Aim 2a) and basic reflex levels (2b) using a physical training approach.
腿部伸展肌肉积极参与重量支持和步行活动。这些肌肉是
通过抑制、双向、力依赖的途径广泛联系在一起,这些途径有助于成功
执行一系列功能行为,包括运动。这些反射通路被认为是
来自高尔基体肌腱器官,被认为可以调节肢体僵硬,促进关节间的协调
动静。这些连接在任意两个肌肉之间的两个方向上的相对大小各不相同。
在对照中,动物在静止时去大脑,但服从主要近端到远端的梯度
在踩着跑步机的时候。这一发现表明,这些反射通路的强度和分布
以依赖于任务的方式受到调制。我们的初步数据显示,胸髓
侧半切立即并持续地改变正态分布和占优势的远端至远端
近端抑制梯度出现。患有这种病变的动物不会表现出卡环-刀抑制,
已知由高尔基体肌腱器官以外的受体介导的现象,由双侧
脊髓后半部分的损伤。力反馈的强度和分布的变化
我们观察到,在运动过程中,肢体僵硬和体重承受能力差是相关的
任务-这两个都是在患有脊髓损伤的人类身上看到的具有挑战性的问题。这些发现
为损伤后导致运动功能障碍的潜在机制提供新的见解
确定一个新的、潜在的康复战略。我们的指导性假设是脊髓损伤诱导的力反馈
调节失调导致对近端肌肉的强烈抑制,导致肌肉不足
在运动的重量支撑阶段,四肢僵硬,并可以使用偏心-
有重点的训练。目前的应用程序已经从协作工作演变为使用大型动物模型,
跨越两个成熟的实验室,汇集了脊髓损伤、可塑性、力反馈方面的专业知识
和运动控制。拟议的研究分为两组实验。第一盘将小心地
描述下胸半切对抑制的亚相步态运动学的影响
力反馈被认为是最活跃的(目标1a)。这些阶段通常与协调的
古怪的活动和/或体重接受/支持。将对SCI前后的数据进行不同时间的比较。在……里面
同样的动物,SCI后的力反馈组织的全面图景将被开发
在两个慢性时间点的末期去大脑研究期间(目标1b)。站着和走着
准备工作将与机械制图方法相结合,用于测试
特定肌肉组合中的异种力反馈反应。在第二组实验中,
基本实验设计相同,只是在训练后2周开始进行偏心训练。
SCI。这使得AIMS 1a和1b中使用的动物可以作为AIMS 2a和2b的对照。古怪的
训练将使用不同的“下坡”步态任务来更强烈地激活力反馈电路。步态
运动学将在选定的子阶段进行仔细评估,以测试在不同平坦和
下坡任务(目标2a)和去大脑,用于表征训练效果的机械制图研究
在特定肌肉组合水平上的力量依赖组织。组织学将全部完成
以验证动物的病变特征。拟议工作中产生的数据将与现有的
实验室数据库,包含来自对照去大脑准备的力反馈结果,以减少
使用的动物数量。总的来说,这些研究将为循证研究提供重要信息。
通过了解扰动力反馈对步态的影响来恢复运动技能(目标1a),
脊髓损伤(目标1b)后这一肢体内控制系统的中断程度以及改变这一点的可能性
使用体育训练方法,在自愿步态(目标2a)和基本反射水平(2b)上进行干扰。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DENA R. HOWLAND其他文献
DENA R. HOWLAND的其他文献
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{{ truncateString('DENA R. HOWLAND', 18)}}的其他基金
Force Feedback Redistribution & Eccentric-Focused Rehab post-SCI
力反馈重新分配
- 批准号:
9905318 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Force Feedback Redistribution & Eccentric-Focused Rehab post-SCI
力反馈重新分配
- 批准号:
10336338 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Altered Motor Function & Force Feedback After Spinal Cord Injury
运动功能改变
- 批准号:
10171923 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Altered Motor Function & Force Feedback After Spinal Cord Injury
运动功能改变
- 批准号:
9310610 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Altered Motor Function & Force Feedback After Spinal Cord Injury
运动功能改变
- 批准号:
9894867 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Spinal cord injury: CS proteoglycans and motor recovery
脊髓损伤:CS 蛋白聚糖和运动恢复
- 批准号:
6863364 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Chondroitin Sulfate Glycosaminoglycan: motor recovery post Spinal Cord Injury
硫酸软骨素糖胺聚糖:脊髓损伤后的运动恢复
- 批准号:
7391653 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Effects of CS GAG degradation on motor recovery post-SCI
CS GAG 降解对 SCI 后运动恢复的影响
- 批准号:
7062126 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Chondroitin Sulfate Glycosaminoglycan: motor recovery post Spinal Cord Injury
硫酸软骨素糖胺聚糖:脊髓损伤后的运动恢复
- 批准号:
7225204 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Effects of CS GAG degradation on motor recovery post-SCI
CS GAG 降解对 SCI 后运动恢复的影响
- 批准号:
6946924 - 财政年份:2004
- 资助金额:
-- - 项目类别:
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