Computation Core

摘要-补偿组件 基因表达数据库（GXD）项目的计算组件通过以下方式支持GXD： 维护和扩展其先进的信息学基础设施。GXD是一个丰富的鼠标资源 发育基因表达数据，通过这些数据，研究人员可以发现对 了解基因的功能和人类发育，健康， 和疾病由计算组件维护的GXD基础设施包含关系 数据库，数据加载和质量控制软件组件，交互式策展界面，现代网络 接口和多个批量数据分发组件。我们将改进系统， 管理和技术开发组件中描述的功能。这将包括：确保 通过定期维护增强GXD信息基础设施的稳健性;通过以下方式提高性能： 升级我们的索引技术堆栈和并行索引分发;升级我们的策展界面， 一个现代化的基于网络的平台;改进/重新训练我们的相关性分类器，使其对scRNA-seq更敏感 加强小鼠解剖学的表现，以涵盖发育分化;以及 扩展元数据捕获以包括特定单元格类型中的表达式。为了实现这些目标，我们将 行业最佳实践，如敏捷开发方法、自动回归测试、定期维护 时间表和全面的质量控制措施。

Abstract - COMPUTATION COMPONENT The Computation Component of the Gene Expression Database (GXD) project supports GXD by maintaining and extending its sophisticated informatics infrastructure. GXD is a rich resource of mouse developmental gene expression data through which researchers can discover expression patterns crucial for understanding the function of genes and the molecular mechanisms that underlie human development, health, and disease. The GXD infrastructure maintained by the Computation Component contains relational databases, data loading and QC software components, an interactive curatorial interface, a modern web interface, and multiple bulk data dissemination components. We will evolve the system to enable the new functionality described in the Curation and Technology Development Components. This will include: ensuring the robustness of GXD’s information infrastructure through regular maintenance; improving performance by upgrading our indexing technology stack and parallelizing index distribution; upgrading our curation interface to a modern web-based platform; refining/retraining our relevance classifier to be more sensitive to scRNA-seq studies; enhancing the representation of mouse anatomy to encompass developmental differentiation; and extending metadata capture to include expression in specific cell types. In achieving these aims, we will apply industry best practices such as agile development methods, automatic regression testing, regular maintenance schedules, and comprehensive quality control measures.