Database and Software Development

小鼠基因组数据库（MGD）的主要使命是促进小鼠作为理解人类生物学和疾病的模型系统的使用。为实现这一目标，我们：1）创建和维护小鼠遗传、基因组和表型数据的综合表示; 2）专业地策划和注释数据，以开发明确的参考数据集和共识观点; 3）收集和合成小鼠和其他哺乳动物之间的比较基因组数据; 4）维护与其他生物信息学资源的丰富链接和合作; 5）开发和支持分析和数据提交工具; 6）开发用户友好的界面，供公众访问小鼠基因组数据; 7）为我们的数据库用户社区提供广泛的技术支持; 8）积极参与与全球研究界的协调。这次更新提出了一个围绕序列，基因和表型主题的计划。序列和序列图：我们将增强序列数据和序列图的表示。序列和序列特征图谱将被整合到MGD中，基因模型将被收集到生物背景中，对象图谱将成为查看和探索MGD的重要机制。基因和基因产物：我们将继续管理MGD的核心数据，并将其扩展到包括基因产物和基因组。核心数据包括有关基因和变异、功能和过程以及哺乳动物同源性的信息。 表型：我们将增强MGD中表型的表示，开发用于描述表型的受控词汇表，并收集和注释表型数据。将强调有关单基因突变、多基因性状、QTL、疾病模型和菌株数据的表型数据。数据库和软件开发：我们将提供统一的软件工作，并设计和实施MGD的数据库和软件变更，以实现计划项目的总体目标。社区推广：作为小鼠的科学社区数据库，MGD高度重视社区参与。我们为我们的数据库用户提供技术支持，并鼓励社区输入，提交，注释和合作。

The primary mission of the Mouse Genome Database (MGD) is to facilitate the use of the mouse as a model system for understanding human biology and disease. To achieve this objective we: 1) create and maintain an integrated representation of mouse genetic, genomic, and phenotypic data; 2) expertly curate and annotate data to develop definitive reference data sets and consensus views; 3) gather and synthesize comparative genomic data between mouse and other mammals; 4) maintain a rich set of links and collaborations with other bioinformatics resources; 5) develop and support analysis and data submission tools; 6) develop user-friendly interfaces for public access to mouse genomic data; 7) provide extensive technical support for our community of database users; 8) actively participate in a coordinate with the global research community. This renewal proposes a Program revolving around the themes of sequences, genes, and phenotypes. Sequences and Sequence Maps: We will enhance the representation of sequence data and maps. Sequences and sequence feature maps will be integrated into MGD, gene models will be collected to biological context, and map of objects will become an important mechanism for viewing and exploring MGD. Genes and Gene Products: We will continue curation of MGD's core data and expand these to include gene products and gene groupings. Core data include information about genes and variants, function and process, and mammalian homologies. Phenotypes: We will enhance the representation of phenotypes in MGD, develop controlled vocabularies for describing phenotypes, and gather and annotate phenotype data. Phenotypic data about single gene mutations, multigenic traits, QTL, disease models and strains data will be emphasized. Database and Software Development: We will provide a unified software effort and design and implement database and software changes to MGD to achieve the overall goals of the Program Project. Community Outreach: As the scientific community database for the mouse, MGD places high priority on community involvement. We provide technical support for our database users and encourage community input, submissions, annotations, and collaborations.