Technical Development

技术开发

• 批准号: 8998695
• 负责人: JOEL E. RICHARDSON
• 金额: $ 37.56万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8998695
• 关键词: Anatomy; Area; Biological; Chickens; Communities; Complement; Data; Data Display; Data Quality; Data Set; Databases; Development; Disease; Galaxy; Gene Expression; Genes; Health; High-Throughput Nucleotide Sequencing; Human Development; Imagery; Informatics; Link; Mining; Modeling; Molecular; Mus; Mutation; Pathway interactions; Pattern; Phenotype; Reporter; Research Personnel; Resources; Source; Structure; Time; Translating; Visual; Work; Xenopus; Zebrafish; abstracting; base; cell type; comparative; gene function; improved; indexing; mouse development; mouse genome; technology development; tool; web interface

PROJECT SUMMARY/ABSTRACT - TECHNICAL DEVELOPMENT The Technology Development Component of the Gene Expression Database (GXD) project complements the Curation and Computation Components by developing interfaces that allow users to realize the value offered by GXD's high-quality, integrated mouse developmental expression data and its connections with the larger biological context at Mouse Genome Informatics (MGI). By providing access to this rich resource of gene expression data, researchers can discover expression patterns crucial for understanding the function of genes and the molecular mechanisms that underlie human development, health, and disease. This component focuses on developing user interface features that provide powerful queries not possible at any other resource, present complementary data views, support rich data interactions, and offer comprehensive and intuitive navigation paths. In this component, we propose work in four broad areas: (1) develop new interfaces in support of high-throughput sequence (HTS) expression data, including access to indexed data sets and loading of selected baseline HTS data; (2) enhance the user's ability to mine GXD expression data through expanded query capabilities and data displays; (3) enhance the user's ability to interpret GXD expression data with improved graphical expression displays and enhanced links to expression data in other developmentally important species; and (4) enhance the user's ability to work with GXD expression data in larger workflows through new data upload, data download, and results combination and forwarding capabilities.   1

项目概要/摘要 - 技术开发 基因表达数据库 (GXD) 项目的技术开发组件补充了 通过开发允许用户实现所提供价值的界面来管理和计算组件 通过 GXD 的高质量、集成的小鼠发育表达数据及其与更大的 小鼠基因组信息学 (MGI) 的生物学背景。通过提供这种丰富的基因资源 表达数据，研究人员可以发现对于理解基因功能至关重要的表达模式 以及人类发展、健康和疾病的分子机制。该组件 专注于开发用户界面功能，提供任何其他资源无法提供的强大查询， 呈现互补的数据视图，支持丰富的数据交互，提供全面直观的 导航路径。在此组件中，我们建议在四个广泛领域开展工作：（1）开发新的接口 支持高通量序列 (HTS) 表达数据，包括访问索引数据集和 加载选定的基线高温超导数据； (2)通过以下方式增强用户挖掘GXD表达数据的能力 扩展的查询功能和数据显示； (3)增强用户解读GXD表达数据的能力 改进了图形表达显示并增强了与其他发育中表达数据的链接 重要物种； (4) 增强用户在更大的工作流程中使用 GXD 表达数据的能力 通过新的数据上传、数据下载以及结果组合和转发功能。   1