Molecular Pathways to Pathogenesis in Toxicology

项目概要/摘要 北卡罗来纳州州立大学“毒理学发病机制的分子途径”NIEHS T32培训 赠款是一个长期的，有影响力的和多学科的倡议，已支持130名博士前学员 在过去的41年里，有18名博士后研究人员。该计划的毕业生进行基础和应用 研究，在大学和学院任教，评估产品安全，并协助公共机构和私人 解决重要的公共卫生和环境问题。我们的使命是提供下一个 一代毒理学家/环境健康科学（EHS）研究人员，具有技术，操作和 进行高影响力的EHS研究所需的专业技能，与各种各样的人进行有效沟通， 观众，并作为多学科团队的一部分，了解人类健康如何受到影响， 环境因素在这次竞争性更新中，我们将继续使用当前的分子途径， 毒理学培训主题和我们的总体系统生物学框架的发病机制。这种方法旨在 整合从生物分子到人类群体的所有生物组织水平， 环境压力因素影响人类健康结果的基本机制。我们有 增加了10名新的研究活跃的教师，共28名导师，提高了我们的导师培训要求， 重组了主要研究领域，更新了核心课程。我们加强了我们的核心专业 在科学严谨性，推理，实验设计和方法，以及数据分析和 通过科学传播的正式培训，资助写作培训，“R”编码，以及 提高再现性的方法。本次NIEHS T32培训补助金的参与导师由 来自NIEHS、其他NIH研究所、其他联邦机构（包括国防部、环保署、国家科学基金会、州 机构和私人基金会。NC State的环境健康科学研究从未如此强大 我们的NIEHS EHS核心中心（P30）的更新和最近获得的超级基金证明了这一点 研究计划（SRP）（P42）。这些中心有助于促进参与者之间的合作， 提供先进的体制基础设施和财政支助， 在NC State进行EHS研究。这两个中心作为一个非凡的资源，为学员通过访问核心 设施、赞助的专题讨论会、研讨会、讲习班和专业发展机会。NIEHS T32培训计划是北卡罗来纳州立大学排名靠前的毒理学研究生课程的基础;我们的良好- 合格的导师，强大的申请人库，以及严格和全面的EHS培训机会将 确保这一举措继续取得成功。我们要求继续支持6名受训人员。

PROJECT SUMMARY/ABSTRACT The North Carolina State University “Molecular Pathways to Pathogenesis in Toxicology” NIEHS T32 training grant is a long-standing, impactful and multidisciplinary initiative that has supported 130 pre-doctoral trainees and 18 post-doctoral researchers over the past 41 years. Graduates of this program conduct basic and applied research, teach at universities and colleges, evaluate product safety, and assist public agencies and private industries in resolving important public health and environmental problems. Our mission is to provide the next generation of toxicologists/environmental health science (EHS) researchers with the technical, operational and professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of audiences, and work as part of multidisciplinary teams to understand how human health is impacted by environmental factors. In this competitive renewal, we will continue with the current Molecular Pathways to Pathogenesis in Toxicology training theme and our overarching systems biology framework. This approach aims to integrate all levels of biological organization from biomolecules to human populations to elucidate the fundamental mechanisms through which environmental stressors influence human health outcomes. We have added 10 new research-active faculty for a total of 28 mentors, enhanced our mentor training requirements, reorganized key research areas, and updated core curricula. We have enhanced our core professional development series in scientific rigor, reasoning, experimental design and methods, and data analysis and interpretation through formal training in science communication, training in grant writing, coding in “R”, and methods for enhancing reproducibility. Participating mentors of this NIEHS T32 training grant are supported by research grants from NIEHS, other NIH Institutes, other federal agencies including DOD, EPA, NSF, state agencies and private foundations. Environmental health science research at NC State has never been stronger as evidenced by the renewal of our NIEHS EHS Core Center (P30) and the recent award of a Superfund Research Program (SRP) (P42). These centers serve to facilitate collaborations among participating mentors/trainees and provide access to cutting-edge institutional infrastructure and financial support to advance EHS research at NC State. Both centers serve as an extraordinary resource for trainees through access to core facilities, sponsored symposia, seminars, workshops and professional development opportunities. The NIEHS T32 training program is the foundation of NC State's highly ranked graduate program in toxicology; our well- qualified mentors, strong pool of applicants, and rigorous and comprehensive EHS training opportunities will ensure the continued success of this initiative. We request continued support for six trainees.