Molecular Pathways to Pathogenesis in Toxicology

毒理学发病机制的分子途径

基本信息

批准号：
10626916
负责人：
Seth William Kullman
金额：
$ 23.86万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
起止时间：
1977-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626916
关键词：
Molecular Pathogenesis Pathway interactions Toxicology

项目摘要

PROJECT SUMMARY/ABSTRACT The North Carolina State University “Molecular Pathways to Pathogenesis in Toxicology” NIEHS T32 training grant is a long-standing, impactful and multidisciplinary initiative that has supported 130 pre-doctoral trainees and 18 post-doctoral researchers over the past 41 years. Graduates of this program conduct basic and applied research, teach at universities and colleges, evaluate product safety, and assist public agencies and private industries in resolving important public health and environmental problems. Our mission is to provide the next generation of toxicologists/environmental health science (EHS) researchers with the technical, operational and professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of audiences, and work as part of multidisciplinary teams to understand how human health is impacted by environmental factors. In this competitive renewal, we will continue with the current Molecular Pathways to Pathogenesis in Toxicology training theme and our overarching systems biology framework. This approach aims to integrate all levels of biological organization from biomolecules to human populations to elucidate the fundamental mechanisms through which environmental stressors influence human health outcomes. We have added 10 new research-active faculty for a total of 28 mentors, enhanced our mentor training requirements, reorganized key research areas, and updated core curricula. We have enhanced our core professional development series in scientific rigor, reasoning, experimental design and methods, and data analysis and interpretation through formal training in science communication, training in grant writing, coding in “R”, and methods for enhancing reproducibility. Participating mentors of this NIEHS T32 training grant are supported by research grants from NIEHS, other NIH Institutes, other federal agencies including DOD, EPA, NSF, state agencies and private foundations. Environmental health science research at NC State has never been stronger as evidenced by the renewal of our NIEHS EHS Core Center (P30) and the recent award of a Superfund Research Program (SRP) (P42). These centers serve to facilitate collaborations among participating mentors/trainees and provide access to cutting-edge institutional infrastructure and financial support to advance EHS research at NC State. Both centers serve as an extraordinary resource for trainees through access to core facilities, sponsored symposia, seminars, workshops and professional development opportunities. The NIEHS T32 training program is the foundation of NC State's highly ranked graduate program in toxicology; our well- qualified mentors, strong pool of applicants, and rigorous and comprehensive EHS training opportunities will ensure the continued success of this initiative. We request continued support for six trainees.

项目摘要/摘要北卡罗来纳州立大学“毒理学发病机理的分子途径” NIEHS T32培训格兰特（Grant）是一项长期，有影响力和多学科的倡议，已支持130名博士前学员在过去的41年中，有18名博士后研究人员。该计划的毕业生进行基本和应用研究，大学和大学的老师，评估产品安全，并协助公共机构和私人解决重要的公共卫生和环境问题的行业。我们的使命是提供下一个毒理学家/环境健康科学（EHS）研究人员的生成技术，运营和进行高影响EHS研究所必需的专业技能，有效地与各种各样的观众，并作为多学科团队的一部分工作，以了解人类健康受到如何影响环境因素。在这种竞争性更新中，我们将继续采用当前的分子途径毒理学培训主题和我们的总体系统生物学框架中的发病机理。这种方法的目的整合从生物分子到人类种群的所有级别的生物组织环境压力源影响人类健康结果的基本机制。我们有增加了10个新的研究活性教师，共有28位导师，这增强了我们的导师培训要求，重组关键的研究领域，并更新了核心课程。我们已经增强了我们的核心专业人士科学严谨，推理，实验设计和方法以及数据分析的发展系列以及通过科学传播中的正式培训，赠款写作，“ R”中的编码以及增强可重复性的方法。这项NIEHS T32培训赠款的参与导师得到了支持 NIEHS，其他NIH机构，其他联邦机构的研究赠款，包括国防部，EPA，NSF，州机构和私人基金会。 NC州的环境健康科学研究从未如此强大正如我们的Niehs EHS Core Center（P30）的续订和最近的超级基金奖励所证明的研究计划（SRP）（P42）。这些中心有助于参与的合作导师/培训，并提供获得尖端机构基础设施和财务支持的访问权限北卡罗来纳州的EHS研究。这两个中心都是通过进入核心的培训的非凡资源设施，赞助的研讨会，半货人，讲习班和专业发展机会。 Niehs T32培训计划是NC State在毒理学领域高度排名的研究生计划的基础；我们的福祉合格的导师，强大的申请人库以及严格而全面的EHS培训机会将确保该计划的持续成功。我们要求持续支持六名学员。