权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Molecular Pathways to Pathogenesis in Toxicology

毒理学发病机制的分子途径

基本信息

批准号：
10626916
负责人：
Seth William Kullman
金额：
$ 23.86万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
起止时间：
1977-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626916
关键词：
Molecular Pathogenesis Pathway interactions Toxicology

项目摘要

PROJECT SUMMARY/ABSTRACT The North Carolina State University “Molecular Pathways to Pathogenesis in Toxicology” NIEHS T32 training grant is a long-standing, impactful and multidisciplinary initiative that has supported 130 pre-doctoral trainees and 18 post-doctoral researchers over the past 41 years. Graduates of this program conduct basic and applied research, teach at universities and colleges, evaluate product safety, and assist public agencies and private industries in resolving important public health and environmental problems. Our mission is to provide the next generation of toxicologists/environmental health science (EHS) researchers with the technical, operational and professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of audiences, and work as part of multidisciplinary teams to understand how human health is impacted by environmental factors. In this competitive renewal, we will continue with the current Molecular Pathways to Pathogenesis in Toxicology training theme and our overarching systems biology framework. This approach aims to integrate all levels of biological organization from biomolecules to human populations to elucidate the fundamental mechanisms through which environmental stressors influence human health outcomes. We have added 10 new research-active faculty for a total of 28 mentors, enhanced our mentor training requirements, reorganized key research areas, and updated core curricula. We have enhanced our core professional development series in scientific rigor, reasoning, experimental design and methods, and data analysis and interpretation through formal training in science communication, training in grant writing, coding in “R”, and methods for enhancing reproducibility. Participating mentors of this NIEHS T32 training grant are supported by research grants from NIEHS, other NIH Institutes, other federal agencies including DOD, EPA, NSF, state agencies and private foundations. Environmental health science research at NC State has never been stronger as evidenced by the renewal of our NIEHS EHS Core Center (P30) and the recent award of a Superfund Research Program (SRP) (P42). These centers serve to facilitate collaborations among participating mentors/trainees and provide access to cutting-edge institutional infrastructure and financial support to advance EHS research at NC State. Both centers serve as an extraordinary resource for trainees through access to core facilities, sponsored symposia, seminars, workshops and professional development opportunities. The NIEHS T32 training program is the foundation of NC State's highly ranked graduate program in toxicology; our well- qualified mentors, strong pool of applicants, and rigorous and comprehensive EHS training opportunities will ensure the continued success of this initiative. We request continued support for six trainees.

项目摘要/摘要北卡罗来纳州立大学“毒理学致病分子途径”NIEHS T32培训 GRANT是一个长期的、有影响力的多学科计划，已经支持了130名博士前实习生以及过去41年中的18名博士后研究人员。该专业的毕业生进行基础和应用研究，在大学和学院任教，评估产品安全，并协助公共机构和私人机构工业在解决重要的公共健康和环境问题方面发挥着重要作用。我们的使命是提供下一个一代毒物学家/环境健康科学(EHS)研究人员，具有技术、操作和进行高影响力的EHS研究所需的专业技能，有效地与各种不同的受众，并作为多学科团队的一部分，了解人类健康如何受到环境因素。在这一竞争更新中，我们将继续使用当前的分子途径来毒理学培训主题中的致病机制和我们的总体系统生物学框架。这种方法的目的是整合从生物分子到人类种群的所有级别的生物组织，以阐明环境应激源影响人类健康结果的基本机制。我们有增加了10名新的研究活跃教师，共28名导师，提高了我们的导师培训要求，重组关键研究领域，更新核心课程。我们已经加强了我们的核心专业在科学严谨性、推理、实验设计和方法以及数据分析和方法方面开发系列通过科学交流方面的正式培训、赠款书写培训、“R”编码进行口译，以及提高重复性的方法。NIEHS T32培训基金的参与导师由来自NIEHS、其他NIH研究所、包括国防部、EPA、NSF、州政府在内的其他联邦机构的研究资助机构和私人基金会。北卡罗来纳州的环境健康科学研究从未像现在这样强大我们NIEHS EHS核心中心的续签(P30)和最近授予的超级基金就是明证研究计划(SRP)(第42页)。这些中心有助于促进参与者之间的合作指导/受训人员，并提供获得尖端机构基础设施和财政支持的途径，以推动北卡罗来纳州EHS研究。这两个中心通过访问CORE，为学员提供了非凡的资源设施、赞助的座谈会、研讨会、讲习班和职业发展机会。NIEHS T32培训计划是北卡罗来纳州立大学在毒理学方面排名很高的研究生计划的基础；我们的良好- 合格的导师、强大的申请者队伍以及严格而全面的EHS培训机会将确保这一倡议继续取得成功。我们请求继续支持六名受训人员。

项目成果

期刊论文数量（118）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.

DOI：
10.1016/j.bbagrm.2015.08.004
发表时间：
2015-10
期刊：
Biochimica et biophysica acta
影响因子：
0
作者：
Ray PD;Huang BW;Tsuji Y
通讯作者：
Tsuji Y

Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages.

DOI：
10.1186/1743-8977-9-14
发表时间：
2012-05-09
期刊：
Particle and fibre toxicology
影响因子：
10
作者：
Lee JK;Sayers BC;Chun KS;Lao HC;Shipley-Phillips JK;Bonner JC;Langenbach R
通讯作者：
Langenbach R

Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna).

DOI：
10.1016/j.aquatox.2010.11.006
发表时间：
2011-01-25
期刊：
AQUATIC TOXICOLOGY
影响因子：
4.5
作者：
Hannas, Bethany R.;Wang, Ying H.;Thomson, Susanne;Kwon, Gwijun;Li, Hong;LeBlanc, Gerald A.
通讯作者：
LeBlanc, Gerald A.

Ligand-Mediated Receptor Assembly as an End Point for High-Throughput Chemical Toxicity Screening.