P20 Exploratory Center for Precision Health in Diverse Populations

项目摘要/摘要 纽约大学迈耶斯护理学院独一无二地准备提出一个P20精确度探索中心 促进代谢综合征(METS)及相关多发性疾病护理研究的不同人群健康 慢性疾病(MCC)。该中心以精准健康生态框架为指导，旨在(1)促进 关于生物多样性的复杂性、关联性、生物多样性及其对个人和家庭的影响的创新研究 利用精确的健康生态观点，包括生物标记物(遗传学/基因组学)， 祖先、社区和环境因素与NINR CDE；(2)发展和维持研究 支持和加速早期职业科学家在不同领域探索MET和MCC的基础设施 从精确的健康生态角度考虑个人和家庭；以及(3)促进 可持续的跨学科协作团队致力于通过获得 外部资金和开展有影响力的研究。代谢综合征(METS)是一组相互关联的健康 将个人置于T2D和CVD严重风险的条件。梅茨是一种前驱状态，它为舞台奠定了基础 用于CVD和T2D。高血压、血脂异常、胰岛素抵抗和肥胖是常见的因素 包括大都会。在美国，大约35%的成年人体内存在甲硫氨酸转移酶。包括2型MCC的家族史 糖尿病(T2D)、高血压和早期心血管疾病(CVD)大大增加了 个人将发展大都会。遗传和环境在慢性疾病中起着作用；这一点尤其正确 大都会队。其他导致METS及其相关的T2D和CVD风险的原因包括遗传易感性、家族史、 低教育程度和社会经济地位，身体质量指数(BMI)增加，以及生活方式因素，尤其是 久坐不动的生活方式/缺乏规律的体力活动；高精制碳水化合物、糖和饱和脂肪的饮食； 吸烟；和物质使用1-6。研究扩展了我们对生物标志物、生活方式、 背景和环境对不同物种Met和相关MCC表型表达的影响， 弱势群体匮乏，亟需援助。基础架构将包括3个核心-管理 由执行委员会和外部咨询委员会指导的核心；试点行政核心 试点可行性资助和科学审查委员会；精密技术资源核心，以及 浓缩计划。两个试点项目将解决甲硫氨酸与睡眠相关的症状群和生物标记物 持续时间和疲劳感。纽约大学迈耶斯护理学院拥有教职员工、研究员和研究科学家 由NIH、CDC、NSF和基金会资助的生物行为研究项目(直接成本为930万美元)， 这涉及MCC的风险、管理和干预。这些研究人员将担任导师， 协作者，以及中心试点绩效指标及其协作者的资源。该中心将允许更多 通过提供生物标志物、遗传/基因组、生物行为、生活方式、 以及环境解释，将为有METS症状的不同人群的护理提供信息。

Project Summary/Abstract The NYU Meyers College of Nursing is uniquely poised to propose a P20 Exploratory Center for Precision Health in Diverse Populations to promote nursing research in metabolic syndrome (MetS) and related multiple chronic conditions (MCC). Guided by a precision health ecological framework, this center aims to (1) promote innovative research on the complexity, relatedness, biodiversity, and impact on individuals and families of MetS and MCC using a precision health ecological perspective, including biomarkers (genetics/genomics), ancestry, community, and environmental factors and the NINR CDE; (2) develop and sustain a research infrastructure to support and accelerate early career scientists in exploring MetS and MCC in diverse individuals and families from a precision health ecological perspective; and (3) facilitate the development of sustainable interdisciplinary collaborative teams dedicated to advancing the science of MCC by obtaining external funding and conducting impactful research. Metabolic syndrome (MetS) is a set of inter-related health conditions placing individuals at serious risk for T2D and CVD. MetS is a prodromal state that sets the stage for CVD and T2D. Hypertension, dyslipidemia, insulin resistance, and obesity are common factors that comprise MetS. MetS is present in ~ 35% of adults in the US. A family history of MCC that includes type 2 diabetes (T2D), hypertension, and early cardiovascular disease (CVD) greatly increases the chance that an individual will develop MetS. Genetics and environment play a role in chronic conditions; this is particularly true of MetS. Other causes of MetS and associated T2D and CVD risk include genetic susceptibility, family history, low education and socioeconomic status, increased body mass index (BMI), and lifestyle factors, especially sedentary lifestyle/lack of regular physical activity; diet high in refined carbohydrates, sugar, and saturated fat; cigarette smoking; and substance use 1-6. Research that expands our understanding of biomarkers, lifestyle, contextual, and environmental impacts on phenotypic expression of MetS and related MCC among diverse, vulnerable populations is lacking and critically needed. The infrastructure will include 3 Cores-Administrative Core guided by an Executive Committee and an External Advisory Committee; Pilot Administrative Core with Pilot Feasibility Funding and a Scientific Review Committee; Precision Technology Resource Core, and an Enrichment Program. Two pilot projects will address symptom clusters and biomarkers of MetS related to sleep duration and fatigue. The NYU Meyers College of Nursing has faculty investigators and research scientists with programs of biobehavioral research, funded by NIH, CDC, NSF, and foundations ($9.3 million in direct costs), that address risk, management, and intervention for MCC. These researchers will serve as mentors, collaborators, and resources for the Center pilot PIs and their collaborators. The Center will allow for more individualized care and extend nursing science by offering biomarker, genetic/genomic, biobehavioral, lifestyle, and environmental explanations that will inform nursing care for diverse populations with symptoms of MetS.