P20 Exploratory Center for Precision Health in Diverse Populations

项目总结/摘要 纽约大学迈耶斯护理学院（NYU Meyers College of Nursing）准备提出一个P20探索中心， 不同人群的健康促进代谢综合征（MetS）及相关多重疾病的护理研究 慢性疾病（MCC）。在精准健康生态框架的指导下，该中心旨在（1）促进 创新研究的复杂性，相关性，生物多样性，以及对个人和家庭的影响， MetS和MCC使用精确的健康生态学观点，包括生物标志物（遗传学/基因组学）， 祖先，社区和环境因素以及NINR CDE;（2）开发和维持研究 基础设施，以支持和加速早期职业科学家在不同领域探索MetS和MCC 从精准健康生态的角度，为个人和家庭提供服务;（3）促进 可持续的跨学科合作团队，致力于通过获得 外部资金和进行有影响力的研究。代谢综合征（MetS）是一组相互关联的健康 使个人处于T2 D和CVD严重风险的条件。代谢综合征是一种前驱状态， CVD和T2 D。高血压、血脂异常、胰岛素抵抗和肥胖是 包括MetS。MetS存在于美国约35%的成年人中。包括2型MCC的家族史 糖尿病（T2 D）、高血压和早期心血管疾病（CVD）大大增加了 个人将开发MetS。遗传和环境在慢性疾病中起作用;这一点尤其如此 的Mets。MetS和相关T2 D和CVD风险的其他原因包括遗传易感性，家族史， 低教育和社会经济地位，增加身体质量指数（BMI）和生活方式因素，特别是 久坐不动的生活方式/缺乏定期的身体活动;富含精制碳水化合物、糖和饱和脂肪的饮食; 吸烟;和物质使用1-6。研究扩展了我们对生物标志物，生活方式， 背景和环境对MetS和相关MCC在不同， 弱势群体缺乏和迫切需要。基础设施将包括3个核心-行政 核心由一个执行委员会和一个外部咨询委员会指导; 试点可行性资金和科学审查委员会;精密技术资源核心，以及 强化计划。两个试点项目将解决与睡眠相关的MetS症状群和生物标志物 持续时间和疲劳。NYU Meyers护理学院有教师调查员和研究科学家， 生物行为研究计划，由NIH、CDC、NSF和基金会资助（直接费用930万美元）， 解决MCC风险、管理和干预问题。这些研究人员将担任导师， 合作者，以及中心试点PI及其合作者的资源。该中心将允许更多 通过提供生物标记、遗传/基因组、生物行为、生活方式 和环境的解释，将告知护理不同人群的MetS症状。

Project Summary/Abstract The NYU Meyers College of Nursing is uniquely poised to propose a P20 Exploratory Center for Precision Health in Diverse Populations to promote nursing research in metabolic syndrome (MetS) and related multiple chronic conditions (MCC). Guided by a precision health ecological framework, this center aims to (1) promote innovative research on the complexity, relatedness, biodiversity, and impact on individuals and families of MetS and MCC using a precision health ecological perspective, including biomarkers (genetics/genomics), ancestry, community, and environmental factors and the NINR CDE; (2) develop and sustain a research infrastructure to support and accelerate early career scientists in exploring MetS and MCC in diverse individuals and families from a precision health ecological perspective; and (3) facilitate the development of sustainable interdisciplinary collaborative teams dedicated to advancing the science of MCC by obtaining external funding and conducting impactful research. Metabolic syndrome (MetS) is a set of inter-related health conditions placing individuals at serious risk for T2D and CVD. MetS is a prodromal state that sets the stage for CVD and T2D. Hypertension, dyslipidemia, insulin resistance, and obesity are common factors that comprise MetS. MetS is present in ~ 35% of adults in the US. A family history of MCC that includes type 2 diabetes (T2D), hypertension, and early cardiovascular disease (CVD) greatly increases the chance that an individual will develop MetS. Genetics and environment play a role in chronic conditions; this is particularly true of MetS. Other causes of MetS and associated T2D and CVD risk include genetic susceptibility, family history, low education and socioeconomic status, increased body mass index (BMI), and lifestyle factors, especially sedentary lifestyle/lack of regular physical activity; diet high in refined carbohydrates, sugar, and saturated fat; cigarette smoking; and substance use 1-6. Research that expands our understanding of biomarkers, lifestyle, contextual, and environmental impacts on phenotypic expression of MetS and related MCC among diverse, vulnerable populations is lacking and critically needed. The infrastructure will include 3 Cores-Administrative Core guided by an Executive Committee and an External Advisory Committee; Pilot Administrative Core with Pilot Feasibility Funding and a Scientific Review Committee; Precision Technology Resource Core, and an Enrichment Program. Two pilot projects will address symptom clusters and biomarkers of MetS related to sleep duration and fatigue. The NYU Meyers College of Nursing has faculty investigators and research scientists with programs of biobehavioral research, funded by NIH, CDC, NSF, and foundations ($9.3 million in direct costs), that address risk, management, and intervention for MCC. These researchers will serve as mentors, collaborators, and resources for the Center pilot PIs and their collaborators. The Center will allow for more individualized care and extend nursing science by offering biomarker, genetic/genomic, biobehavioral, lifestyle, and environmental explanations that will inform nursing care for diverse populations with symptoms of MetS.