P20 Exploratory Center for Precision Health in Diverse Populations

项目摘要 P20探索中心在不同人群中的精准健康的丰富计划侧重于 在代谢综合征（MetS）及其导致的多种慢性疾病中培养护士科学家 （MCC）。丰富计划旨在促进发展早期职业护士科学家成为成功的， NIH资助的独立调查员。强化计划的首要目标是支持护士 科学家在学习如何（1）理解和评估如何潜在的生物学和病理生理学的 MetS及其产生的MCC导致不同的症状和生物标志物表达。(2)的影响进行分析 种族、民族、年龄和性别对导致代谢综合征及其 由此产生的MCC，以及这些因素如何影响有效地进行护理研究所需的方法， 不同的人群。(3)将MetS及其产生的MCC实验室研究（T1/T2）带到床边（T3）， 将其融入日常临床实践（T4）。(4)发展有效和高效的跨学科协作 在MetS及其产生的MCC进行研究的团队。(5)理解并有效使用核心数据 在MetS及其产生的MCC研究的设计和实施的元素。(6)评价 伦理，法律的和社会影响的执行科学对MetS和其产生的MCC在不同的 人口，包括生物标志物的使用。该中心将通过利用广泛的 纽约大学Rory Meyers护理学院（NYU Meyers）和更大的NYU科学学院提供的资源 #21453;，并制定新的方案。NYU Meyers的现有资源包括内部赠款 评论，演讲者系列，NIDA资助的P30药物使用和艾滋病毒研究中心，哈特福德研究所 老年护理和NSF资助的X-lab，为医疗保健带来技术解决方案。新程序 专为提供个人、团体和同伴指导而开发。这些领域的项目将包括 科学进展每月研讨会，一个期刊俱乐部，和一个写作责任和同行指导小组。 我们还将扩大导师和能力，在我们的博士后奖学金和访问学者计划， MetS及其产生的MCC的面积。强化计划将制定和实施有针对性的 研讨会和为期一天的方法和科学方案，针对需要的领域，通过 年度需求评估。充实方案活动将具有高度可持续性， 融入NYU Meyers的结构，并融入现有的资源，结构和资金流。由 在五年P20期间结束时，新课程将由教师自我维持，并得到 纽约大学迈耶斯学院院长。浓缩计划将由一位经验丰富的外部科学家进行评估， 根据过程和结果的测量进行年度审查。评价将由以下人员审查： 丰富计划主任和行政核心，以确保该计划最大限度地提高 发展早期职业护士科学家在MetS及其导致的MCC在不同人群中的研究。

PROJECT SUMMARY The Enrichment Program of the P20 Exploratory Center for Precision Health in Diverse Populations focuses on developing nurse scientists in Metabolic Syndrome (MetS) and its resulting multiple chronic conditions (MCC). The Enrichment Program seeks to foster the development early career nurse scientists into successful, NIH-funded, independent investigators. The overarching aims of the Enrichment Program are to support nurse scientists in learning how to (1) Understand and evaluate how the underlying biology and pathophysiology of MetS and its resulting MCC leads to differential symptom and biomarker expression. (2) Analyze the impact of race, ethnicity, age, and sex on biological, behavioral, and environmental factors leading to MetS and its resulting MCC, and how these factors influence the methods needed to effectively perform nursing research in diverse populations. (3) Take MetS and its resulting MCC bench research (T1/T2) to the bedside (T3) and integrate it into everyday clinical practice (T4). (4) Develop effective and efficient collaborative interdisciplinary teams to carry out research in MetS and its resulting MCC. (5) Understand and effectively use core data elements in the design and implementation of research studies in MetS and its resulting MCC. (6) Evaluate the ethical, legal and social implications of performing science on MetS and its resulting MCC in diverse populations, including the use of biomarkers. The center will achieve these aims by leveraging the extensive resources available at the NYU Rory Meyers College of Nursing (NYU Meyers) and the greater NYU scientific community as well as by developing new programs. Existing resources at NYU Meyers include internal grant reviews, speaker series, the NIDA-funded P30 Center in Drug Use and HIV Research, the Hartford Institute for Geriatric Nursing, and the NSF-funded X-lab, which brings technology solutions to healthcare. New programs developed specifically to provide individual, group, and peer mentoring. Programs in these areas will include a Science in Progress monthly seminar, a journal club, and a writing accountability and peer mentoring group. We will also expand mentorship and capacity in our post-doctoral fellowships and visiting scholar programs in the area of MetS and its resulting MCC. The Enrichment Program will develop and implement targeted seminars and day-long methodologic and scientific programs, targeted to areas of need as identified through an annual needs assessment. The Enrichment Program activities will be highly sustainable, as they will be woven into the fabric of NYU Meyers and fit into existing resources, structures, and funding streams. By the end of the five year P20 period, the new programs will be self-sustained by the faculty and by support from the Dean of NYU Meyers. The Enrichment Program will be evaluated by an experienced external scientist, who will perform an annual review based on process and outcome measurements. The evaluation will be reviewed by the Enrichment Program Director and the Administrative Core to ensure that the program maximizes the development of early-career nurse scientists in research on MetS and its resulting MCC in diverse populations.