Administrative Core

摘要 这个孔特中心代表了五位资深科学家和几位有成就的初级科学家的合作。 科学家，专业知识涵盖人类神经系统研究，细胞和神经元 在非人类灵长类动物和计算建模的整体研究，解决大脑运作，在每个 水平我们专注于一个广泛的科学和翻译重要性的关键问题-大脑的节奏 动力学及其作为大脑用来优化其目标导向采样的工具的机械作用 或者叫“主动感知”我们都是各自领域的领导者，正如我们的出版记录所显示的那样， 赠款和概念/技术创新。我们每个人都带来了学员和同事的网络， 分享我们的奉献精神，以找到突破我们的机械理解的大脑动力学，以及 明确认识到这必然是一项多学科的事业，理想上适合于，事实上需要， 像孔蒂中心这样的支持机制。核心A有几个必要的监督和管理 功能，包括作为中心的通信骨干，并保持最高 整个中心的道德和财务责任标准。该核心还将负责 支持评估和建设性活动，包括年度外部科学咨询 委员会会议、半年度内部科学和教育咨询委员会会议以及 指导委员会半月会议。该核心将支持教育外联活动，包括： 1)夏季本科生研究经验（SURE），2）多样性和少数民族代表不足 研究金方案，3）科学界妇女专题讨论会，4）中心在哥伦比亚举办的系列研讨会，5）a 每周网络期刊俱乐部，以及6）该中心参与了由2名 我们的项目领导者-年轻人的前沿。(http：//kids.frontiersin.org/）。核心A将支持团队- 在年度中心期间，中心的建设，科学交流和方案完善 务虚会，和几个层次的技术支持项目和核心，以及一个中心网站和其他 公共拓展的形式。在这次修订后的申请中，我们大大扩大了中心的重点， 电刺激和药理学操作提供了更直接的访问基础 “因果”机制，核心A的支持是至关重要的风险。除此之外， 我们的目标是为中心的各个项目之间的协同作用和中心的 智力敏捷，以便能够利用新发现，并适应出现的问题和挑战 在融资周期内。我们将在多个层面上实现这一目标。核心A活动的时间轴， 该中心作为一个整体在图17的“总体”中给出。

Abstract This Conte Center represents a collaboration of five senior scientists and several accomplished junior scientists, with expertise spanning domains of neural systems studies in humans, cellular and neuron ensemble studies in nonhuman primates and computational modeling, addressing brain operations at each level. We focus on a critical issue of broad scientific and translational importance – the brain's rhythmic dynamics and their mechanistic roles as instruments that the brain uses to optimize its goal-directed sampling of information, or “Active Sensing.” We are all leaders in our fields, as shown by our records of publications, grants and conceptual/technical innovation. We each bring with us networks of trainees and colleagues who share our dedication to find a break-through in our mechanistic understanding of brain dynamics, as well as a clear recognition that this is by necessity a multidisciplinary enterprise, ideally suited to, and in fact requiring, a support mechanism like the Conte Center. Core A has several necessary supervisory and administrative functions, including serving as the communication backbone of the Center, and maintaining the highest standards of ethical and financial accountability across the Center. This core will also be responsible for supporting evaluative and constructive activities including the annual External Scientific Advisory Committee meeting, the semiannual Internal Scientific and Educational Advisory Committee meetings, and the semi-monthly Steering Committee meetings. This Core will support educational outreach activities including: 1) the Summer Undergraduate Research Experience (SURE), 2) the diversity and Under-Represented Minority Fellowship program, 3) the Women-in-Science Symposia, 4) the Center's Seminar Series at Columbia, 5) a weekly Web Journal Club, and 6) the Center's participation in a science journal for teenagers initiated by 2 of our Project Leaders – Frontiers for Young Minds. (http://kids.frontiersin.org/). Core A will support team- building, scientific exchange and programmatic refinement of the Center during the Annual Center Retreat, and several levels of technical support to Projects and Cores, as well as a Center Website and other forms of Public Outreach. In this revised application, we are significantly expanding the Center's emphasis on electrical stimulation and pharmacological manipulations that provide more direct access to underlying “causal” mechanisms, and Core A support is critical to that venture. Beyond all of this this our overarching goal is to provide the greatest possible support for synergy across projects in the Center and for the Center's intellectual agility so that it can exploit new discoveries, and adapt to problems and challenges that emerge during its funding cycle. We will pursue this goal on multiple levels. The timeline of Core A activities relative to the Center as a whole is given in “Overall” Fig 17.