Data Standardizing and Sharing

数据标准化与共享

• 批准号: 10175038
• 负责人: Alexandre R. Franco
• 金额: $ 25.34万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175038
• 关键词: Achievement; Address; Animals; Area; Basic Science; Brain; Clinical; Cognitive; Computer software; Country; Data; Data Aggregation; Data Collection; Data Set; Effectiveness; Electrocorticogram; Epilepsy; Goals; Human; Implant; Maps; Medical center; Methods; Monkeys; Neurobiology; Operative Surgical Procedures; Patients; Procedures; Protocols documentation; Published Comment; Research; Role; Scientist; Site; Source; Standardization; Surface; Translational Research; Variant; base; brain surgery; data format; data integrity; data management; data sharing; data standards; experimental study

ABSTRACT Electrocorticography (ECoG) refers to recording from the surface of the brain. ECoG has been used for decades for select clinical purposes — most commonly to identify functional and epileptic brain areas in people with epilepsy — and occasionally for research. The important role of ECoG for basic research long been under-appreciated. Over the past several years, the unique qualities of ECoG have become widely and increasingly recognized by scientists engaged in basic and translational research. The primary sources of human ECoG data are patients with epilepsy patients, who receive subdural implants to map epileptic foci and function prior to invasive brain surgery. Thus, data collection is limited to the 125 class-IV epilepsy centers across the country that perform such surgeries, and to about 5-10 patients in each of these centers per year. Hence, larger-scale human ECoG studies and integration with animal ECoG studies, such as those proposed in this application, require that data are collected at multiple medical centers. However, each of them uses variable data collection protocols, data collection software, data collection hardware, data formats, and methods and procedures to keep track of meta information (e.g., the current cognitive status of the subject or other comments). These variations greatly impede, and in practice often prohibit the conduction of ECoGbased studies across multiple sites. Thus, achievement of the scientific goals of the proposed Center relies considerably on the effectiveness and efficiency of the mechanisms to address or mitigate these issues. The Data Management/Sharing (DMS) Core facilitates data collection, integration and sharing of human and animal electrocorticographic (ECoG) data across participating Center sites and projects. While ECoG data provide enormous opportunities for achieving the scientific goals of the Center, each of the five human ECoG sites (and the one monkey ECoG site) in the Center will provide data from only a few subjects each year, and there are important variabilities across subjects and technical setup at each of these sites. Thus, the overarching goal of the DMS Core is to remove or mitigate these variabilities so as to maximize the scientific value of the ECoG datasets produced by the Center and to minimize the difficulty in accessing them. In specific terms, AIM 1 is to provide support for implementation of experiments in standardized software; AIM 2 is to coordinate data collection at ECoG sites using standardized protocols; AIM 3 is to interface with those sites to aggregate data and to verify data integrity; and AIM 4 is to make data available to the Center's four scientific projects using robust and easy-to-use mechanisms.

抽象的 皮质电图（ECoG）是指从大脑表面进行记录。 ECoG 已用于 用于特定临床目的数十年——最常见的是识别人类的功能性和癫痫性大脑区域 患有癫痫症——偶尔也用于研究。 ECoG对于基础研究的重要作用早已被人们所认识 被低估。在过去的几年里，ECoG 的独特品质已得到广泛应用和认可。 越来越受到从事基础和转化研究的科学家的认可。主要来源 人类 ECoG 数据是癫痫患者，他们接受硬膜下植入物来绘制癫痫病灶并 侵入性脑部手术前的功能。因此，数据收集仅限于 125 个 IV 级癫痫中心 全国各地都有此类手术中心，每年每个中心都会为大约 5-10 名患者提供服务。 因此，更大规模的人类 ECoG 研究以及与动物 ECoG 研究的整合，例如提出的那些 在此应用程序中，要求在多个医疗中心收集数据。然而，他们每个人都使用 可变数据采集协议、数据采集软件、数据采集硬件、数据格式和 跟踪元信息的方法和程序（例如，受试者当前的认知状态或 其他评论）。这些变化极大地阻碍了基于 ECoG 的测量，并且在实践中常常禁止该测量的进行。 跨多个站点的研究。因此，拟议中心科学目标的实现依赖于 很大程度上取决于解决或缓解这些问题的机制的有效性和效率。这 数据管理/共享（DMS）核心促进人类和动物的数据收集、集成和共享 参与中心站点和项目的皮质电图 (ECoG) 数据。虽然 ECoG 数据提供 实现该中心的科学目标的巨大机会，五个人类 ECoG 站点中的每一个站点 该中心的（以及一只猴子 ECoG 站点）每年仅提供少数受试者的数据，并且 这些站点的主题和技术设置之间存在重要的差异。因此，总体 DMS Core 的目标是消除或减轻这些变异性，从而最大限度地发挥科学价值 由中心制作的 ECoG 数据集，并尽量减少访问它们的难度。具体而言，AIM 1是为标准化软件中实验的实施提供支持；目标2是协调数据 使用标准化协议在 ECoG 站点进行收集； AIM 3 是与这些站点交互以聚合数据 并验证数据完整性； AIM 4 是为该中心的四个科学项目提供数据 强大且易于使用的机制。