PHORA: A Clinical Decision Support Tool for Patients with Pulmonary Arterial Hypertension

PHORA：肺动脉高压患者的临床决策支持工具

• 批准号: 10187768
• 负责人: RAYMOND Louis Benza
• 金额: $ 65.64万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187768
• 关键词: Academia; Address; Algorithms; Bayesian Network; Biomedical Engineering; Caring; Chronic Disease; Clinical; Clinical Decision Support Systems; Clinical Trials; Clinical Trials Design; Communication; Communities; Computer software; Consensus; Data; Data Set; Databases; Decision Making; Decision Support Systems; Development; Diagnosis; Disease; Disease Management; Early Diagnosis; Education; Equation; Evolution; Feedback; Focus Groups; Foundations; Future; Generations; Goals; Healthcare; Heart failure; Individual; Industry; Intention; Intervention; Investigational Drugs; Knowledge; Life; Light; Machine Learning; Meta-Analysis; Modeling; Morbidity - disease rate; Multicenter Trials; Observational Study; Outcome; Patient risk; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Physicians; Pulmonary Hypertension; Pulmonary Vascular Resistance; Pulmonary vessels; Quality of life; Rare Diseases; Registries; Resources; Risk; Risk Assessment; Standardization; Statistical Methods; Structure; Surrogate Endpoint; Testing; Therapeutic; Therapeutic Intervention; Training; Treatment Effectiveness; Uncertainty; Validation; base; clinical database; clinical decision support; clinical encounter; clinical predictors; cohort; computer human interaction; computer program; computer science; cost; cost effective; cost effectiveness; data management; data mining; effective therapy; hospital readmission; hypertension treatment; improved; individual patient; individualized medicine; intervention cost; medical specialties; mortality; multidisciplinary; novel therapeutics; outcome prediction; predictive modeling; prognostic; prognostic tool; prospective; prototype; pulmonary arterial hypertension; response; shared decision making; success; support tools; survival prediction; theories; time use; tool; usability; user centered design; user-friendly; vascular abnormality

ABSTRACT This application seeks to develop a multi-platform clinical decision support system (CDSS) in pulmonary arterial hypertension (PAH) for physicians, PHORA (Pulmonary Hypertension Outcomes Risk Assessment), which can be used to: (a) guide therapeutic decisions and (b) optimize clinical trial design. We will achieve this goal by utilizing clinical trial data from several large databases of completed trials in PAH, an ongoing PAH registry (REVEAL), as well as observational sessions with physicians. The proposed aims co- create the CDSS with a multi-disciplinary group of specialties including: biomedical engineering, advanced PAH physicians, computer science (machine learning/data mining), human computer interaction, and allied health care experts. Our intention is to engage all stakeholders to achieve consensus and thereby assure the acceptance of PHORA into practice. Successful completion of this project will lay the foundation for a prospective, multi-center trial in which PHORA will be evaluated with respect to long-term patient outcomes. The ultimate aim is to disseminate this resource so as to improve the efficiency, efficacy, and cost- effectiveness of this treatment for PAH.

摘要 本申请旨在开发一个多平台的临床决策支持系统（CDSS）， 医生动脉高血压（PAH），PHORA（肺动脉高血压结局风险 评估），可用于：（a）指导治疗决策和（B）优化临床试验设计。我们 将通过利用来自PAH已完成试验的几个大型数据库的临床试验数据来实现这一目标， 正在进行的PAH登记研究（REVEAL），以及与医生的观察性会议。建议的目标是： 创建CDSS与专业的多学科组，包括：生物医学工程，先进的 PAH医师、计算机科学（机器学习/数据挖掘）、人机交互及相关 卫生保健专家。我们的意图是让所有利益攸关方参与进来，以达成共识，从而确保 将PHORA付诸实践。该项目的成功完成将为 一项前瞻性、多中心试验，将评价PHORA对患者长期结局的影响。 最终目的是传播这一资源，以提高效率、效益和成本- 这种治疗对PAH的有效性。

项目成果

Maternal and fetal outcomes in pregnant women with pulmonary hypertension: The impact of left heart disease.

肺动脉高压孕妇的母婴结局：左心疾病的影响。

• DOI: 10.1016/j.ijcchd.2022.100354
• 发表时间: 2022
• 期刊: International journal of cardiology. Congenital heart disease
• 作者: Marshall,WilliamH;Gee,Stephen;Lim,Woobeen;Lastinger,LaurenT;Cackovic,Michael;Benza,RaymondL;Daniels,CurtJ;Bradley,ElisaA;Rajpal,Saurabh
• 通讯作者: Rajpal,Saurabh