The Development of a Biatrial Catheter for a Cardiopulmonary Support System in Pulmonary Arterial Hypertension

摘要 肺动脉高压仍然是一种毁灭性的慢性疾病。尽管有各种新的 尽管有多种治疗方法，但这种疾病过程仍然是高度病态和致命的。大多数治疗只是权宜之计， 由于这种疾病过程的潜伏发作和后期识别，其效果最低。双肺 移植是唯一有效的治疗方法;然而，由于器官的稀缺和上市的不平等，大多数人 病人在轮候期间不大可能接受器官移植。提供有效的长期支持 能够减轻右心室负荷并保护肺血管系统的系统将提供 支持和潜在的恢复或管理药物支持。目标和长期 该项目的目标是设计一种导管，该导管最终将与肺支持系统耦合， 可延长肺动脉高压患者的生存期，提高药物治疗肺动脉高压患者的能力， 也为那些在肺移植等待名单上的人提供了接受器官的机会。我们打算 通过开发一种创新的双腔导管来实现这一点，该双腔导管可以在长时间内定位和固定， 一段时间，使用一种新的工程机制，并将适当卸载右心室和肺 通过心房间配置在脉管系统中进行。这将进一步包括一个创新的监测系统， 控制血流，保护失代偿的左心室，防止左心衰。

ABSTRACT Pulmonary arterial hypertension continues to be a devastating chronic disease. Despite a variety of new therapies, this disease process remains highly morbid and fatal. Most therapies are only temporizing and are minimally effective because of the insidious onset and late recognition of this disease process. Double lung transplantation is the only effective treatment; however, because of scarcity of organs and listing inequities, most patients are unlikely to receive a transplant while on the waiting list. Developing an effective long-term support system that can offload the right ventricle and protect the pulmonary vasculature would provide a bridge of support and potential for recovery or management on pharmacological support. The objective and long-term goal of this project is to design a catheter that will eventually be coupled with a pulmonary support system that can prolong the survival and enhance the ability to medically treat patients with pulmonary artery hypertension, as well as provide a chance for those on the lung transplant waiting list to receive an organ. We intend to accomplish this by developing an innovative dual lumen catheter that can be positioned and fixed for a prolonged period of time using a novel engineering mechanism and will properly unload the right ventricle and pulmonary vasculature via an inter-atrial configuration. This will further include an innovative monitoring system to monitor and control flows and protect a deconditioned left ventricle, preventing left sided heart failure.