The Development of a Biatrial Catheter for a Cardiopulmonary Support System in Pulmonary Arterial Hypertension

肺动脉高压心肺支持系统双心导管的研制

基本信息

项目摘要

ABSTRACT Pulmonary arterial hypertension continues to be a devastating chronic disease. Despite a variety of new therapies, this disease process remains highly morbid and fatal. Most therapies are only temporizing and are minimally effective because of the insidious onset and late recognition of this disease process. Double lung transplantation is the only effective treatment; however, because of scarcity of organs and listing inequities, most patients are unlikely to receive a transplant while on the waiting list. Developing an effective long-term support system that can offload the right ventricle and protect the pulmonary vasculature would provide a bridge of support and potential for recovery or management on pharmacological support. The objective and long-term goal of this project is to design a catheter that will eventually be coupled with a pulmonary support system that can prolong the survival and enhance the ability to medically treat patients with pulmonary artery hypertension, as well as provide a chance for those on the lung transplant waiting list to receive an organ. We intend to accomplish this by developing an innovative dual lumen catheter that can be positioned and fixed for a prolonged period of time using a novel engineering mechanism and will properly unload the right ventricle and pulmonary vasculature via an inter-atrial configuration. This will further include an innovative monitoring system to monitor and control flows and protect a deconditioned left ventricle, preventing left sided heart failure.
摘要 肺动脉高压仍然是一种毁灭性的慢性疾病。尽管有各种新的 尽管有多种治疗方法,但这种疾病过程仍然具有高度病态和致命性。大多数治疗只是权宜之计, 由于这种疾病过程的潜伏发作和后期识别,其效果最低。双肺 移植是唯一有效的治疗方法;然而,由于器官的稀缺和上市的不平等,大多数人 病人在轮候期间不大可能接受器官移植。提供有效的长期支持 能够减轻右心室负荷并保护肺血管系统的系统将提供 支持和潜在的恢复或管理药物支持。目标和长期 该项目的目标是设计一种导管,该导管最终将与肺支持系统耦合, 可延长肺动脉高压患者的生存期,提高药物治疗肺动脉高压患者的能力, 也为那些在肺移植等待名单上的人提供了接受器官的机会。我们打算 通过开发一种创新的双腔导管来实现这一点,该双腔导管可以在长时间内定位和固定, 一段时间,使用一种新的工程机制,并将适当卸载右心室和肺 通过心房间配置在脉管系统中进行。这将进一步包括一个创新的监测系统, 控制血流,保护失代偿的左心室,防止左心衰。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

RAYMOND Louis Benza其他文献

RAYMOND Louis Benza的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('RAYMOND Louis Benza', 18)}}的其他基金

PHORA-Pulmonary Hypertension Outcome Risk Assessment
PHORA-肺动脉高压结果风险评估
  • 批准号:
    10990081
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
PHORA: A Clinical Decision Support Tool for Patients with Pulmonary Arterial Hypertension
PHORA:肺动脉高压患者的临床决策支持工具
  • 批准号:
    9207492
  • 财政年份:
    2017
  • 资助金额:
    $ 33.6万
  • 项目类别:
PHORA: A Clinical Decision Support Tool for Patients with Pulmonary Arterial Hypertension
PHORA:肺动脉高压患者的临床决策支持工具
  • 批准号:
    10187768
  • 财政年份:
    2017
  • 资助金额:
    $ 33.6万
  • 项目类别:
Salivary Gland-Based Gene Therapy for Pulmonary Arterial Hypertension
基于唾液腺的肺动脉高压基因治疗
  • 批准号:
    8608587
  • 财政年份:
    2013
  • 资助金额:
    $ 33.6万
  • 项目类别:
IGF::OT::IGF Vascular Interventions/Innovations and Therapeutic Advances (VITA): A Study to Explore the Feasibility of using Combined Modalities to Test the Safety of CaridMEMS Device in PAH Patients
IGF::OT::IGF 血管干预/创新和治疗进展 (VITA):一项探索使用组合方式测试 CaridMEMS 设备在 PAH 患者中安全性的可行性的研究
  • 批准号:
    8947688
  • 财政年份:
    2013
  • 资助金额:
    $ 33.6万
  • 项目类别:
Salivary Gland-Based Gene Therapy for Pulmonary Arterial Hypertension
基于唾液腺的肺动脉高压基因治疗
  • 批准号:
    8445512
  • 财政年份:
    2013
  • 资助金额:
    $ 33.6万
  • 项目类别:
Pharmacogenomics in Pulmonary Arterial Hypertension
肺动脉高压的药物基因组学
  • 批准号:
    6966645
  • 财政年份:
    2005
  • 资助金额:
    $ 33.6万
  • 项目类别:
Pharmacogenomics in Pulmonary Arterial Hypertension
肺动脉高压的药物基因组学
  • 批准号:
    7118932
  • 财政年份:
    2005
  • 资助金额:
    $ 33.6万
  • 项目类别:
Pharmacogenomics in Pulmonary Arterial Hypertension
肺动脉高压的药物基因组学
  • 批准号:
    7465528
  • 财政年份:
    2005
  • 资助金额:
    $ 33.6万
  • 项目类别:
Pharmacogenomics in Pulmonary Arterial Hypertension
肺动脉高压的药物基因组学
  • 批准号:
    7252454
  • 财政年份:
    2005
  • 资助金额:
    $ 33.6万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.6万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了