ICP-QQQ
ICP-QQQ
批准号:
10177184
负责人:
Ana Maria Rule
金额:
$34.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-07-15 至 2022-06-30
关键词:
14 year oldAmerican IndiansArsenicBiomedical ResearchClinical InvestigatorCommunitiesCoupledDataDigestionDisciplineElectronic cigaretteEnvironmental Engineering technologyEnvironmental HealthEnvironmental PollutantsEquipmentEvaluationExposure toFundingGlioblastomaGoalsGrantHealthHeart DiseasesHigh Pressure Liquid ChromatographyImmune responseInductively Coupled Plasma Mass SpectrometryInfectionInfluenzaMagnetismMalignant NeoplasmsMalignant neoplasm of liverMedicalMedicineMetal exposureMetalsMinorPilot ProjectsPopulation HeterogeneityPreventionPublic HealthPublic Health SchoolsResearchResearch PersonnelResearch Project GrantsResearch SupportResource SharingRisk FactorsServicesStrokeStudentsSystemTechnical ExpertiseTechnologyToxic effectTrace metalTranslationsUnited States National Institutes of HealthUniversitiescancer survivalequipment acquisitionexperiencehyperthermia treatmentinstrumentinstrumentationmass spectrometermedical schoolsmicrowave electromagnetic radiationnovel therapeutic interventionparticlerapid growthschool healthtumor
中文摘要
项目总结/文摘:
英文摘要
Project Summary/Abstract:
The overall goal of this proposal is to acquire funds to purchase a triple quadrupole mass spectrometer and a
new microwave digestor to replace a 14-year old Agilent 7500ce ICP-MS and a MARS5 microwave. The funds
will be used to purchase an Agilent 8900 ICP-QQQ system that can be coupled with our existing Agilent 1260
HPLC system which will be dedicated to support NIH-funded investigators requiring quantitative metal analysis,
including metal speciation. A group of investigators (6 major, 5 minor) has been identified whose research
(75.1% NIH-funded) will greatly benefit from analyses performed with the requested instrumentation. The Trace
Metals Lab (TML) in the Department of Environmental Health and Engineering at Johns Hopkins Bloomberg
School of Public Health houses the only ICP-MS in the medical campus, which includes the School of Medicine
(SOM) and the School of Public Health. The TML has been providing accurate, sensitive, and reliable trace metal
analysis for health-related research since 2006. This shared resource provides funded investigators with
technical expertise and access to large equipment for quantitative analysis of trace metals. The JHU TML is
used heavily by NIH-funded grants supporting research that ranges from exposure to metals from e-cigarettes
(R01), evaluation of Magnetic Hyperthermia Therapy (MHT) against infiltrating glioblastoma (R01) and liver
cancer tumors (R01), assessment of arsenic exposure on immune responses to influenza (R01), Arsenic and
other metal exposures in American Indian communities (R01), among others. The research that will benefit
from this instrumentation will have enormous impacts on the disciplines of Medicine and Public Health. With ICP-
QQQ, HPLC, microwave digestion, and Single Particle analysis capabilities, our lab will continue to advance the
translation of basic biomedical research to treatments and cures, and will also contribute to prevention through
strategies for reducing exposure to environmental pollutants for diverse populations. The number of basic and
clinical investigators requiring analytical services of trace metals has experienced a rapid growth. As a result,
usage of the existing ICP-MS instrument is currently at full capacity. The new instrumentation will also benefit
studies that are not currently NIH funded, pilot projects to collect data for NIH grants, and student research
projects. The ICP-MS capability of the JHU TML will also contribute to the long-range biomedical research goals
of the Johns Hopkins University. This instrumentation will benefit research to understand basic cellular toxicity,
risk factors for infection, develop important new therapeutic strategies against cancer, and advance our
understanding of stroke mechanisms, heart disease, cancer survival, and immune responses. As outlined in this
application, acquisition of this equipment will make this technology available to a large number of investigators,
continuing with the goals of the Trace Metals Lab, the Department of Environmental Health and Engineering, the
Bloomberg School or Public Health, the Johns Hopkins University, and the Biomedical community as a whole.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Residential proximity to metal emitting industries and toenail metal concentration in the US Gulf States.
美国海湾国家的住宅靠近金属排放工业和趾甲金属集中区。
DOI:
10.21203/rs.3.rs-3210942/v1
发表时间:
2023
期刊:
Research square
影响因子:
--
作者:
[Lin,JoyceJy, Werder,Emily, Lawrence,KaitlynG, Jackson2nd,WBraxton, Sandler,DaleP, Dickerson,AishaS, Engel,LawrenceS, Rule,AnaM]
通讯作者:
Rule,AnaM
Respiratory Effects of Exposure to Metals from Electronic Cigarettes (RE-EMIT)
-
批准号:10115962
-
项目类别:
-
资助金额:$18.81万
-
财政年份:2018
-
负责人:Ana Maria Rule
-
依托单位:
The Exposure to Metals from E-Cigarettes (EMIT) Study
-
批准号:9788464
-
项目类别:
-
资助金额:$44.68万
-
财政年份:2018
-
负责人:Ana Maria Rule
-
依托单位:
Development of New Generation Gas and Vapor Sensors Using Organic Electronics
-
批准号:8527548
-
项目类别:
-
资助金额:$19.44万
-
财政年份:2012
-
负责人:Ana Maria Rule
-
依托单位:
海外基金