Long-term consequences of SARS-CoV-2 infection and COVID-19 disease among American Indians: an ambidirectional cohort study in the Cherokee Nation

美洲印第安人中 SARS-CoV-2 感染和 COVID-19 疾病的长期后果：切罗基族的双向队列研究

• 批准号: 10438443
• 负责人: Katrin Gaardbo Kuhn
• 金额: $ 33.58万
• 依托单位: CHEROKEE NATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438443
• 关键词: 5 year old; Acute; Address; Adult; Affect; Age; American; American Indians; Anxiety; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 patient; COVID-19 risk; COVID-19 test; Cardiovascular system; Caring; Cessation of life; Cherokee Indian; Child; Child Health; Clinic; Cohort Studies; Coin; Communities; Community Surveys; Contact Tracing; Disease; Dizziness; Fatigue; Future; Gender; Goals; Guidelines; Health; Health care facility; Healthcare; Healthcare Systems; Heart; Hospitalization; Incidence; Indian reservation; Infection; Intensive Care; Interview; Knowledge; Long COVID; Long-Term Effects; Medical; Memory; Mental Depression; Native American Research Center for Health; Oklahoma; Outpatients; Paper; Participant; Patient risk; Patients; Persons; Population; Prevalence; Public Health; Publishing; Questionnaires; Reporting; Review Literature; Risk; SARS-CoV-2 infection; SARS-CoV-2 negative; SARS-CoV-2 positive; Severity of illness; Surveys; Symptoms; Telephone Interviews; Test Result; Testing; Time Study; Visit; base; care providers; cohort; comorbidity; coronavirus disease; experience; gastrointestinal; health inequalities; high risk; improved; long term consequences of COVID-19; long-term sequelae; member; mortality; pandemic disease; persistent symptom; post SARS-CoV-2 infection; post-COVID-19; prospective; prospective test; psychologic; rural counties; severe COVID-19; symptom management; tribal community

ABSTRACT Following the immediate effect of acute COVID-19 on patients and healthcare systems, it has now also become apparent that as many as 35% of COVID patients experience long-term health consequences of their infection. These consequences are reported to include heart-related problems, digestive issues, fatigue and dizziness, as well as anxiety and depression, but the full spectrum of symptoms and their duration is still unknown. American Indian people have been disproportionately affected by the COVID pandemic due to underlying medical conditions combined with high COVID-19 incidence and mortality, and general health inequalities. As a result, the impact of long-term symptoms is also expected to be severe in this population. In this study, we propose to examine the extent of long-term symptoms following SARS-CoV-2 infection among American Indian people residing in the Cherokee Nation Reservation. Given the strong impact of COVID-19 and the lack of understanding of its long-term effect in the Cherokee Nation, there is a crucial need for improved management among these patients in the community. This study will be among the first to assess long-term symptoms in an American Indian population and as such will establish a precedent and framework for future studies in the American Indian population. The overall goal of the study is to identify and quantify long-term COVID symptoms among American Indian people and to develop guidelines for how to predict, assess and manage these symptoms. This is an ambidirectional cohort study following a total of 200 persons retrospectively (tested for infection within the past six months) and prospectively (tested for infection from the time the study is initiated, and onwards). Using this approach, we will achieve our aims of identifying long-term symptoms in SARS-CoV-2 positive versus negative American Indian persons, predicting who is at risk of developing these symptoms and ultimately produce guidelines for predicting and identifying who is most at risk of becoming affected by COVID symptoms in the long run and how manage the symptoms either in centralized dedicated healthcare clinics or through primary care providers.

摘要