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Image-Guided Radiation Therapy System for Small Animals

小动物图像引导放射治疗系统

基本信息

批准号：
10176686
负责人：
GREGORY MATHEW PALMER
金额：
$ 60万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2022-06-30
项目状态：
已结题

项目摘要

Radiation therapy is used to treat approximately 50% of all patients with cancer. To improve the cure rate with radiation therapy and to decrease the short- and long-term side effects of radiation, we have received multiple NIH grants to study radiation biology in small animals. Duke University was one of the first centers to obtain a first generation microCT/micro-irradiator for use in small animals (X-RAD 225Cx), which has supported one of the most successful research programs in the country in radiation therapy, radiation injury, and imaging. Major technological improvements in target localization, treatment planning, and radiation delivery in combination with functional imaging have occurred since that time, and these capabilities are essential for our radiation research to better mimic human radiation therapy and therefore have the most relevance and impact. To improve our ability to carry out clinically meaningful research in radiation biology, we request a shared instrument that combines on-board imaging capabilities (micro-CT), with conformal small beam radiation therapy and advanced treatment planning software that is capable of the same treatment planning approaches and metrics most commonly used today in the clinic. This is incorporated into the Xstrahl Small Animal Radiation Research Platform (SARRP). The proposed instrument uses state-of-the-art technology for small animals that rigorously simulates the radiation therapy planning and treatment conditions of our patients. We propose to use this technology to investigate (1) mechanisms of tumor control and (2) normal tissue injury by radiation therapy. We will utilize the on-board imaging and the custom collimators to safely deliver large doses of radiation with high precision and accuracy to dissect mechanisms of tumor control. This approach will allow us to study the clinically meaningful endpoint of tumor cure. Moreover, the ability to image small animals and localize the tumor target before each treatment will facilitate fractionated radiation therapy schedules for small animals, which are routinely used to treat patients in the clinic. The instrument will also allow us to have the unprecedented ability to focus radiation therapy on part of an organ, to create dose volume histograms (DVHs) to study mechanisms of normal tissue injury, and to model advanced approaches for cancer therapy (e.g. sparing lymph nodes for immunotherapy studies). This approach will avoid multi-organ injury by the radiation treatment and will thereby facilitate studies of radiation-induced normal tissue injury in small animals. In summary, this technology offers a dramatic improvement in our ability to study fundamental radiation biology questions using the same technology with which we treat patients. Combining this novel instrument with the extensive expertise in radiation research at Duke will bring about new discoveries and will facilitate their translation into improved cancer therapy.

放射疗法用于治疗约50%的癌症患者。提高治愈为了降低放射治疗的短期和长期副作用，我们获得了多项国家卫生研究院的资助，用于研究小动物的辐射生物学。杜克大学是第一中心获得第一代用于小动物的微型CT/微型辐照器（X-RAD 225Cx），该项目支持了该国最成功的辐射研究项目之一治疗、辐射损伤和成像。目标定位的重大技术改进，治疗计划和放射治疗与功能成像的结合已经出现，这些能力对于我们的辐射研究更好地模拟人类辐射至关重要治疗，因此具有最大的相关性和影响力。提高我们临床开展能力在辐射生物学的有意义的研究，我们要求一个共享的仪器，结合船上成像能力（微型CT），具有适形小束放射治疗和高级治疗计划软件，能够相同的治疗计划方法和指标，目前在临床上普遍使用。这是纳入Xstrahl小动物辐射研究平台（SARRP）。拟议的仪器使用最先进的技术，严格模拟放射治疗计划和治疗条件的动物，患者我们建议使用这项技术来研究（1）肿瘤控制机制和（2）放射治疗造成的正常组织损伤。我们将利用机载成像和定制准直器，以高精度和准确度安全地提供大剂量辐射，肿瘤控制机制。这种方法将使我们能够研究具有临床意义的终点，肿瘤治疗此外，成像小动物和定位肿瘤靶点的能力，治疗将促进小动物的分次放射治疗时间表，这是常规的用于在诊所治疗患者。该仪器还将使我们拥有前所未有的能力，将放射治疗集中在器官的一部分，以创建剂量体积直方图（DVH）来研究正常组织损伤的机制，并模拟癌症治疗的先进方法（例如，保留淋巴结用于免疫治疗研究）。这种方法将避免多器官损伤，放射治疗，从而促进研究辐射引起的正常组织损伤，在小动物总之，这项技术大大提高了我们研究基础知识的能力。放射生物学的问题使用相同的技术与我们治疗病人。组合该杜克大学在辐射研究方面拥有广泛专业知识的新型仪器将带来新的这些发现将有助于将其转化为改进的癌症治疗。