Acquisition of preclinical PET/CT scanner for BSL3 imaging research

采购用于 BSL3 成像研究的临床前 PET/CT 扫描仪

• 批准号: 10177588
• 负责人: RICHARD Andre LAFOREST
• 金额: $ 57.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2024-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177588
• 关键词: Address; Advisory Committees; Animals; Bacteria; Biological; Communicable Diseases; Communities; Complement; Complex; Detection; Disease; Emission-Computed Tomography; Equipment; Family; Funding; Goals; Grant; Infection; Infectious Agent; Inflammatory Response; Institution; Magnetic Resonance Imaging; Monitor; PET/CT scan; Parasites; Play; Positron-Emission Tomography; Research; Research Personnel; Role; Safety; Series; Site; Stretching; System; Therapy Evaluation; Time; Tissues; Treatment Efficacy; United States National Institutes of Health; Universities; Virus; Washington; X-Ray Computed Tomography; base; cost; diagnosis evaluation; disease diagnosis; drug development; flexibility; fungus; imaging facilities; imaging system; improved; in vivo; in vivo imaging system; microPET; molecular imaging; optical imaging; pathogen; portability; pre-clinical; pre-clinical research; precision medicine; programs; research and development; tool

Summary Molecular imaging with small animal Positron Emission Tomography/ Computed Tomography (micro-PET/CT) is an established component of preclinical research and drug development which provides in-vivo quantitative molecular imaging in a real-time for disease diagnosis and therapy evaluation, and plays an increasingly crucial role in preclinical precision medicine research. In this proposal, we are requesting funds to acquire a benchtop micro-PET/CT imaging system as a shared research tool to support NIH-funded research of infection diseases. The funds obtained through this grant will be used to acquire a PET/CT scanner for small animal molecular imaging research to be sited within a Biological Safety Level-3 Facility (BSL3). Research in infectious diseases at WUSM stretches across numerous departments with programs addressing every family of pathogen, including bacteria, viruses, fungi and parasites. Molecular imaging (i.e., positron emission tomography, PET) complemented with computed tomography holds great promise for the early, accurate detection of infection and infectious disease, and monitoring of treatment efficacies. The presence of an infectious organism in tissue initiates a complex series of inflammatory responses. We have identified a portable benchtop micro-PET/CT system with advanced preclinical molecular imaging that simplifies workflow, improves siting flexibility, and reduces operational cost. This system will complement our existing real-time and noninvasive molecular imaging equipment that includes small animal MRI and IVIS Spectrum optical imaging. Our long-term goal is to establish a BSL3 Imaging Facility at Washington University to serve the needs of researchers, including other institutions, and more broadly within the community. The requested benchtop micro-PET/CT will be used by NIH funded investigators and will be overseen by a broad-based advisory committee. Strong institutional support and financial commitment will be provided to assure optimal use.

总结 小动物正电子发射断层扫描/计算机断层扫描的分子成像 （微型PET/CT）是临床前研究和药物开发的既定组成部分 其提供用于疾病诊断的实时体内定量分子成像， 治疗评估，并在临床前精准医学中发挥着越来越重要的作用 research.在这项提案中，我们要求资金购买台式微型PET/CT 成像系统作为共享的研究工具，以支持NIH资助的感染性疾病研究。 通过这笔赠款获得的资金将用于购买PET/CT扫描仪， 动物分子成像研究将在生物安全三级设施（BSL 3）内进行。 WUSM的传染病研究跨越了许多部门， 针对包括细菌、病毒、真菌和寄生虫在内的所有病原体家族的计划。 分子成像（即，正电子发射断层扫描，PET）补充计算机 断层扫描为早期、准确检测感染和传染性疾病提供了巨大的希望。 疾病和监测治疗效果。感染性有机体的存在 组织引发一系列复杂的炎症反应。我们发现了一个便携式 台式微型PET/CT系统，具有先进的临床前分子成像， 工作流程，提高选址灵活性，降低运营成本。该系统将补充 我们现有的实时和非侵入性的分子成像设备，包括小动物， MRI和IVIS光谱光学成像。我们的长期目标是建立一个BSL 3成像 在华盛顿大学的设施，以满足研究人员的需要，包括其他机构， 更广泛地在社区内。要求的台式微型PET/CT将由以下人员使用： NIH资助了研究人员，并将由一个基础广泛的咨询委员会监督。强 将提供机构支助和财政承诺，以确保最佳利用。